Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037230957> ?p ?o ?g. }
- W2037230957 endingPage "83" @default.
- W2037230957 startingPage "75" @default.
- W2037230957 abstract "Fungal species present in extreme low pH environments are expected to have adapted for tolerance to high H(+) concentrations. However, their adaptability mechanism is unclear. In this study, we isolated an acid-tolerant strain of Penicillium funiculosum, which can grow actively at pH 1.0 and thrived in pH 0.6. A major facilitator superfamily transporter (PfMFS) was isolated from an acid-sensitive random insertional mutant (M4) of the fungus. It encodes a putative protein of 551 residues and contains 14 transmembrane-spanning segments. A targeted mutant (M7) carrying an inactivated copy of PfMFS showed an obvious reduction of growth compared with the wild type (WT) and complementation of M7 with PfMFS restored the wild-type level of growth at pH 1.0. Further data showed that the wild-type showed higher intracellular pH than M7 in response to pH 1. Subcellular localization showed that PfMFS was a cell membrane protein. Homology modeling showed structural similarity with an MFS transporter EmrD from Escherichiacoli. These results demonstrate that the PfMFS transporter is involved in the acid resistance and intracellular pH homeostasis of P. funiculosum." @default.
- W2037230957 created "2016-06-24" @default.
- W2037230957 creator A5030721622 @default.
- W2037230957 creator A5044070333 @default.
- W2037230957 creator A5052669378 @default.
- W2037230957 creator A5084054641 @default.
- W2037230957 date "2014-08-01" @default.
- W2037230957 modified "2023-09-27" @default.
- W2037230957 title "Role of a major facilitator superfamily transporter in adaptation capacity of Penicillium funiculosum under extreme acidic stress" @default.
- W2037230957 cites W124763801 @default.
- W2037230957 cites W1489968996 @default.
- W2037230957 cites W1494313201 @default.
- W2037230957 cites W1518634270 @default.
- W2037230957 cites W1538833285 @default.
- W2037230957 cites W1579194849 @default.
- W2037230957 cites W1603426439 @default.
- W2037230957 cites W1876643911 @default.
- W2037230957 cites W1912107272 @default.
- W2037230957 cites W1965924285 @default.
- W2037230957 cites W1969224299 @default.
- W2037230957 cites W1976969980 @default.
- W2037230957 cites W1977549676 @default.
- W2037230957 cites W1990658717 @default.
- W2037230957 cites W1991973333 @default.
- W2037230957 cites W1994704939 @default.
- W2037230957 cites W1999305069 @default.
- W2037230957 cites W2001334866 @default.
- W2037230957 cites W2001488720 @default.
- W2037230957 cites W2004181413 @default.
- W2037230957 cites W2004254961 @default.
- W2037230957 cites W2019240958 @default.
- W2037230957 cites W2027613309 @default.
- W2037230957 cites W2034314982 @default.
- W2037230957 cites W2052602128 @default.
- W2037230957 cites W2066624240 @default.
- W2037230957 cites W2068393186 @default.
- W2037230957 cites W2076203685 @default.
- W2037230957 cites W2076795031 @default.
- W2037230957 cites W2078950716 @default.
- W2037230957 cites W2080997141 @default.
- W2037230957 cites W2083654565 @default.
- W2037230957 cites W2084364838 @default.
- W2037230957 cites W2085509368 @default.
- W2037230957 cites W2088551831 @default.
- W2037230957 cites W2095172074 @default.
- W2037230957 cites W2103580208 @default.
- W2037230957 cites W2107872932 @default.
- W2037230957 cites W2117936698 @default.
- W2037230957 cites W2118079644 @default.
- W2037230957 cites W2120211414 @default.
- W2037230957 cites W2124637227 @default.
- W2037230957 cites W2124804313 @default.
- W2037230957 cites W2129093253 @default.
- W2037230957 cites W2143573319 @default.
- W2037230957 cites W2149007198 @default.
- W2037230957 cites W2152434411 @default.
- W2037230957 cites W2155733474 @default.
- W2037230957 cites W2156212384 @default.
- W2037230957 cites W2157357875 @default.
- W2037230957 cites W2164706557 @default.
- W2037230957 cites W2183764711 @default.
- W2037230957 cites W4253379290 @default.
- W2037230957 cites W4253850261 @default.
- W2037230957 doi "https://doi.org/10.1016/j.fgb.2014.06.002" @default.
- W2037230957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24959657" @default.
- W2037230957 hasPublicationYear "2014" @default.
- W2037230957 type Work @default.
- W2037230957 sameAs 2037230957 @default.
- W2037230957 citedByCount "27" @default.
- W2037230957 countsByYear W20372309572015 @default.
- W2037230957 countsByYear W20372309572016 @default.
- W2037230957 countsByYear W20372309572017 @default.
- W2037230957 countsByYear W20372309572018 @default.
- W2037230957 countsByYear W20372309572019 @default.
- W2037230957 countsByYear W20372309572020 @default.
- W2037230957 countsByYear W20372309572021 @default.
- W2037230957 countsByYear W20372309572022 @default.
- W2037230957 countsByYear W20372309572023 @default.
- W2037230957 crossrefType "journal-article" @default.
- W2037230957 hasAuthorship W2037230957A5030721622 @default.
- W2037230957 hasAuthorship W2037230957A5044070333 @default.
- W2037230957 hasAuthorship W2037230957A5052669378 @default.
- W2037230957 hasAuthorship W2037230957A5084054641 @default.
- W2037230957 hasBestOaLocation W20372309571 @default.
- W2037230957 hasConcept C104317684 @default.
- W2037230957 hasConcept C118892022 @default.
- W2037230957 hasConcept C134897140 @default.
- W2037230957 hasConcept C143065580 @default.
- W2037230957 hasConcept C149011108 @default.
- W2037230957 hasConcept C188082640 @default.
- W2037230957 hasConcept C207583985 @default.
- W2037230957 hasConcept C515207424 @default.
- W2037230957 hasConcept C55493867 @default.
- W2037230957 hasConcept C62465871 @default.
- W2037230957 hasConcept C79879829 @default.
- W2037230957 hasConcept C86803240 @default.
- W2037230957 hasConceptScore W2037230957C104317684 @default.
- W2037230957 hasConceptScore W2037230957C118892022 @default.