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- W2037248339 abstract "Abstract Early models for the etiology of schizophrenia focused on dopamine neurotransmission because of the powerful anti‐psychotic action of dopamine antagonists. Nevertheless, recent evidence increasingly supports a primarily glutamatergic dysfunction in this condition, where dopaminergic disbalance is a secondary effect. A current model for the pathophysiology of schizophrenia involves a dysfunctional mechanism by which the NMDA receptor (NMDAR) hypofunction leads to a dysregulation of GABA fast‐ spiking interneurons, consequently disinhibiting pyramidal glutamatergic output and disturbing the signal‐to‐noise ratio. This mechanism might explain better than other models some cognitive deficits observed in this disease, as well as the dopaminergic alterations and therapeutic effect of anti‐psychotics. Although the modulation of glutamate activity has, in principle, great therapeutic potential, a side effect of NMDAR overactivation is neurotoxicity, which accelerates neuropathological alterations in this illness. We propose that metabotropic glutamate receptors can have a modulatory effect over the NMDAR and regulate excitotoxity mechanisms. Therefore, in our view metabotropic glutamate receptors constitute a highly promising target for future drug treatment in this disease." @default.
- W2037248339 created "2016-06-24" @default.
- W2037248339 creator A5020071547 @default.
- W2037248339 creator A5030398514 @default.
- W2037248339 creator A5043566847 @default.
- W2037248339 creator A5048605818 @default.
- W2037248339 date "2009-10-16" @default.
- W2037248339 modified "2023-10-17" @default.
- W2037248339 title "Molecular mechanisms underlying glutamatergic dysfunction in schizophrenia: therapeutic implications" @default.
- W2037248339 cites W1539003584 @default.
- W2037248339 cites W1563185661 @default.
- W2037248339 cites W1563427807 @default.
- W2037248339 cites W1585966888 @default.
- W2037248339 cites W1616286551 @default.
- W2037248339 cites W1914381346 @default.
- W2037248339 cites W1963956528 @default.
- W2037248339 cites W1965494865 @default.
- W2037248339 cites W1965632303 @default.
- W2037248339 cites W1972253384 @default.
- W2037248339 cites W1973927342 @default.
- W2037248339 cites W1978523366 @default.
- W2037248339 cites W1978618811 @default.
- W2037248339 cites W1979210141 @default.
- W2037248339 cites W1981534919 @default.
- W2037248339 cites W1982307161 @default.
- W2037248339 cites W1982624291 @default.
- W2037248339 cites W1985241009 @default.
- W2037248339 cites W1991324653 @default.
- W2037248339 cites W1997031801 @default.
- W2037248339 cites W1998679999 @default.
- W2037248339 cites W2001232602 @default.
- W2037248339 cites W2001954021 @default.
- W2037248339 cites W2006072274 @default.
- W2037248339 cites W2009772283 @default.
- W2037248339 cites W2014504186 @default.
- W2037248339 cites W2014667545 @default.
- W2037248339 cites W2016717347 @default.
- W2037248339 cites W2017010915 @default.
- W2037248339 cites W2017267321 @default.
- W2037248339 cites W2017991212 @default.
- W2037248339 cites W2021216098 @default.
- W2037248339 cites W2022809683 @default.
- W2037248339 cites W2023705353 @default.
- W2037248339 cites W2024415031 @default.
- W2037248339 cites W2028554055 @default.
- W2037248339 cites W2028884770 @default.
- W2037248339 cites W2029172258 @default.
- W2037248339 cites W2030205241 @default.
- W2037248339 cites W2030756376 @default.
- W2037248339 cites W2031986055 @default.
- W2037248339 cites W2032208151 @default.
- W2037248339 cites W2035611331 @default.
- W2037248339 cites W2035785231 @default.
- W2037248339 cites W2037395811 @default.
- W2037248339 cites W2037988324 @default.
- W2037248339 cites W2041826378 @default.
- W2037248339 cites W2043941998 @default.
- W2037248339 cites W2044598463 @default.
- W2037248339 cites W2044829843 @default.
- W2037248339 cites W2045381879 @default.
- W2037248339 cites W2046327370 @default.
- W2037248339 cites W2047007360 @default.
- W2037248339 cites W2048080687 @default.
- W2037248339 cites W2049147617 @default.
- W2037248339 cites W2053245102 @default.
- W2037248339 cites W2054484015 @default.
- W2037248339 cites W2059049668 @default.
- W2037248339 cites W2061058027 @default.
- W2037248339 cites W2061688783 @default.
- W2037248339 cites W2063464429 @default.
- W2037248339 cites W2063619823 @default.
- W2037248339 cites W2065940220 @default.
- W2037248339 cites W2067795636 @default.
- W2037248339 cites W2068057735 @default.
- W2037248339 cites W2068522619 @default.
- W2037248339 cites W2071090720 @default.
- W2037248339 cites W2072471087 @default.
- W2037248339 cites W2074359816 @default.
- W2037248339 cites W2077609442 @default.
- W2037248339 cites W2078167209 @default.
- W2037248339 cites W2079300654 @default.
- W2037248339 cites W2083198527 @default.
- W2037248339 cites W2083875726 @default.
- W2037248339 cites W2083980310 @default.
- W2037248339 cites W2084200464 @default.
- W2037248339 cites W2085493579 @default.
- W2037248339 cites W2086382977 @default.
- W2037248339 cites W2086614619 @default.
- W2037248339 cites W2087097962 @default.
- W2037248339 cites W2089912569 @default.
- W2037248339 cites W2089966958 @default.
- W2037248339 cites W2097960662 @default.
- W2037248339 cites W2098673651 @default.
- W2037248339 cites W2101896923 @default.
- W2037248339 cites W2102256305 @default.
- W2037248339 cites W2106208373 @default.
- W2037248339 cites W2110835949 @default.
- W2037248339 cites W2113709916 @default.