Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037248799> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2037248799 endingPage "456a" @default.
- W2037248799 startingPage "456a" @default.
- W2037248799 abstract "Protein structures are evolutionarily more conserved than sequences, and sequences with very low sequence identity often share the same fold. This leads to the concept of protein designability. Elucidating the relationship between protein sequence and the three-dimensional structure that the sequence folds into is an important problem in computational structural biology. 45 protein chains (40-mer) from the PDB were analyzed. Hydrophobic-polar sequences were generated and contact energies calculated by threading each sequence onto Cα coarse-grained protein structures. The minimum energy structure for each sequence was identified and the number of sequences folding to each fold (designability) was obtained. Highly designable structures obtained were found to be popular structural motifs. H/P mutational analysis of sequences folding to each conformation was performed. As designability increases, the total number of mutations was also found to increase. The sequences folding to the most designable structure (helix-turn-helix motif) were also analyzed. The degree of connectivity at each residue position correlates inversely with the degree of solvent exposure. The surface residues had fewer interactions compared to buried residues. Highly connected residues were also found to be more conserved than the other residue positions. i.e. the diversity of the sequences increases with designability; however, there are conserved positions. Using tripeptide percentages of the most and least designable sequences, ten-fold cross-validation was performed and designable sequences were found to be distinguishable (accuracies > 85%, AUC > 0.87). The same set of sequences was then used as a training set with a test set of real binary protein sequences. Designable sequences obtained mimic real protein sequences with accuracies of nearly 60%. Highly and poorly designable classes can be used to train machine learning algorithms to identify which real protein sequences are designable." @default.
- W2037248799 created "2016-06-24" @default.
- W2037248799 creator A5023494109 @default.
- W2037248799 creator A5072961886 @default.
- W2037248799 date "2012-01-01" @default.
- W2037248799 modified "2023-09-26" @default.
- W2037248799 title "Diversity of Sequences Folding to Highly and Poorly Designable Structures" @default.
- W2037248799 doi "https://doi.org/10.1016/j.bpj.2011.11.2500" @default.
- W2037248799 hasPublicationYear "2012" @default.
- W2037248799 type Work @default.
- W2037248799 sameAs 2037248799 @default.
- W2037248799 citedByCount "1" @default.
- W2037248799 countsByYear W20372487992020 @default.
- W2037248799 crossrefType "journal-article" @default.
- W2037248799 hasAuthorship W2037248799A5023494109 @default.
- W2037248799 hasAuthorship W2037248799A5072961886 @default.
- W2037248799 hasBestOaLocation W20372487991 @default.
- W2037248799 hasConcept C104317684 @default.
- W2037248799 hasConcept C119599485 @default.
- W2037248799 hasConcept C127413603 @default.
- W2037248799 hasConcept C152769699 @default.
- W2037248799 hasConcept C167625842 @default.
- W2037248799 hasConcept C18051474 @default.
- W2037248799 hasConcept C185592680 @default.
- W2037248799 hasConcept C199216141 @default.
- W2037248799 hasConcept C200307862 @default.
- W2037248799 hasConcept C204328495 @default.
- W2037248799 hasConcept C206276672 @default.
- W2037248799 hasConcept C2776545253 @default.
- W2037248799 hasConcept C2778112365 @default.
- W2037248799 hasConcept C45484198 @default.
- W2037248799 hasConcept C47701112 @default.
- W2037248799 hasConcept C54355233 @default.
- W2037248799 hasConcept C55493867 @default.
- W2037248799 hasConcept C65556437 @default.
- W2037248799 hasConcept C70721500 @default.
- W2037248799 hasConcept C8010536 @default.
- W2037248799 hasConcept C86803240 @default.
- W2037248799 hasConceptScore W2037248799C104317684 @default.
- W2037248799 hasConceptScore W2037248799C119599485 @default.
- W2037248799 hasConceptScore W2037248799C127413603 @default.
- W2037248799 hasConceptScore W2037248799C152769699 @default.
- W2037248799 hasConceptScore W2037248799C167625842 @default.
- W2037248799 hasConceptScore W2037248799C18051474 @default.
- W2037248799 hasConceptScore W2037248799C185592680 @default.
- W2037248799 hasConceptScore W2037248799C199216141 @default.
- W2037248799 hasConceptScore W2037248799C200307862 @default.
- W2037248799 hasConceptScore W2037248799C204328495 @default.
- W2037248799 hasConceptScore W2037248799C206276672 @default.
- W2037248799 hasConceptScore W2037248799C2776545253 @default.
- W2037248799 hasConceptScore W2037248799C2778112365 @default.
- W2037248799 hasConceptScore W2037248799C45484198 @default.
- W2037248799 hasConceptScore W2037248799C47701112 @default.
- W2037248799 hasConceptScore W2037248799C54355233 @default.
- W2037248799 hasConceptScore W2037248799C55493867 @default.
- W2037248799 hasConceptScore W2037248799C65556437 @default.
- W2037248799 hasConceptScore W2037248799C70721500 @default.
- W2037248799 hasConceptScore W2037248799C8010536 @default.
- W2037248799 hasConceptScore W2037248799C86803240 @default.
- W2037248799 hasIssue "3" @default.
- W2037248799 hasLocation W20372487991 @default.
- W2037248799 hasOpenAccess W2037248799 @default.
- W2037248799 hasPrimaryLocation W20372487991 @default.
- W2037248799 hasRelatedWork W1998728673 @default.
- W2037248799 hasRelatedWork W2037248799 @default.
- W2037248799 hasRelatedWork W2038819579 @default.
- W2037248799 hasRelatedWork W2058651019 @default.
- W2037248799 hasRelatedWork W2092087990 @default.
- W2037248799 hasRelatedWork W2123053169 @default.
- W2037248799 hasRelatedWork W2160529747 @default.
- W2037248799 hasRelatedWork W2166675948 @default.
- W2037248799 hasRelatedWork W3044593510 @default.
- W2037248799 hasRelatedWork W4232102222 @default.
- W2037248799 hasVolume "102" @default.
- W2037248799 isParatext "false" @default.
- W2037248799 isRetracted "false" @default.
- W2037248799 magId "2037248799" @default.
- W2037248799 workType "article" @default.