Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037250014> ?p ?o ?g. }
- W2037250014 endingPage "1867" @default.
- W2037250014 startingPage "1855" @default.
- W2037250014 abstract "Age-related macular degeneration (AMD) causes visual impairment in the elderly. In non-neovascular AMD, studies involving human subjects have suggested potential involvement of aberrant lipid metabolism. However, there have been no reports on gene expression patterns in animal models of non-neovascular AMD with abnormal lipid metabolism such as apolipoprotein E knockout and human apolipoprotein E2 transgenic mice. Transcriptome analysis was performed using retinal pigment epithelium cells of apoE knockout and apolipoprotein E2 mice using microarray analysis. C57BL/6, Rxrb, Pparbp, Vldlr, and Edf1, which are primarily related to lipid metabolism, were upregulated, while Tgfbr1 and Pdgfb, which are related to pathologic angiogenesis in AMD, were downregulated in both types of mice. Apolipoprotein E knockout and apolipoprotein E2 mice showed characteristic gene expression patterns in the transcriptome analysis of primary retinal pigment epithelium cells. These results suggest that specific genes associated with lipid metabolism and angiogenesis are involved in the pathogenesis and progression of AMD." @default.
- W2037250014 created "2016-06-24" @default.
- W2037250014 creator A5003008869 @default.
- W2037250014 creator A5014685670 @default.
- W2037250014 creator A5015181969 @default.
- W2037250014 creator A5031380253 @default.
- W2037250014 creator A5031847563 @default.
- W2037250014 creator A5060616519 @default.
- W2037250014 creator A5088734205 @default.
- W2037250014 creator A5089533243 @default.
- W2037250014 creator A5089754599 @default.
- W2037250014 date "2015-01-01" @default.
- W2037250014 modified "2023-09-23" @default.
- W2037250014 title "Gene expression profiles of primary retinal pigment epithelial cells from apolipoprotein E knockout and human apolipoprotein E2 transgenic mice" @default.
- W2037250014 cites W1481498843 @default.
- W2037250014 cites W1508669465 @default.
- W2037250014 cites W1511664208 @default.
- W2037250014 cites W1941964179 @default.
- W2037250014 cites W1987253025 @default.
- W2037250014 cites W1990558727 @default.
- W2037250014 cites W1992788147 @default.
- W2037250014 cites W1997480136 @default.
- W2037250014 cites W1997617084 @default.
- W2037250014 cites W1998525139 @default.
- W2037250014 cites W2006534012 @default.
- W2037250014 cites W2009182898 @default.
- W2037250014 cites W2010345260 @default.
- W2037250014 cites W2019951047 @default.
- W2037250014 cites W2023721626 @default.
- W2037250014 cites W2027191356 @default.
- W2037250014 cites W2034826672 @default.
- W2037250014 cites W2034968148 @default.
- W2037250014 cites W2038861414 @default.
- W2037250014 cites W2047205361 @default.
- W2037250014 cites W2051842051 @default.
- W2037250014 cites W2058195170 @default.
- W2037250014 cites W2058381006 @default.
- W2037250014 cites W2061673720 @default.
- W2037250014 cites W2069183328 @default.
- W2037250014 cites W2076084849 @default.
- W2037250014 cites W2076232924 @default.
- W2037250014 cites W2076566237 @default.
- W2037250014 cites W2098571122 @default.
- W2037250014 cites W2105828900 @default.
- W2037250014 cites W2109763816 @default.
- W2037250014 cites W2133465414 @default.
- W2037250014 cites W2144469043 @default.
- W2037250014 cites W2158217645 @default.
- W2037250014 cites W2398107675 @default.
- W2037250014 cites W66100551 @default.
- W2037250014 doi "https://doi.org/10.4238/2015.march.13.14" @default.
- W2037250014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25867331" @default.
- W2037250014 hasPublicationYear "2015" @default.
- W2037250014 type Work @default.
- W2037250014 sameAs 2037250014 @default.
- W2037250014 citedByCount "2" @default.
- W2037250014 countsByYear W20372500142017 @default.
- W2037250014 countsByYear W20372500142021 @default.
- W2037250014 crossrefType "journal-article" @default.
- W2037250014 hasAuthorship W2037250014A5003008869 @default.
- W2037250014 hasAuthorship W2037250014A5014685670 @default.
- W2037250014 hasAuthorship W2037250014A5015181969 @default.
- W2037250014 hasAuthorship W2037250014A5031380253 @default.
- W2037250014 hasAuthorship W2037250014A5031847563 @default.
- W2037250014 hasAuthorship W2037250014A5060616519 @default.
- W2037250014 hasAuthorship W2037250014A5088734205 @default.
- W2037250014 hasAuthorship W2037250014A5089533243 @default.
- W2037250014 hasAuthorship W2037250014A5089754599 @default.
- W2037250014 hasBestOaLocation W20372500141 @default.
- W2037250014 hasConcept C102230213 @default.
- W2037250014 hasConcept C104317684 @default.
- W2037250014 hasConcept C118487528 @default.
- W2037250014 hasConcept C134018914 @default.
- W2037250014 hasConcept C141035611 @default.
- W2037250014 hasConcept C142724271 @default.
- W2037250014 hasConcept C150194340 @default.
- W2037250014 hasConcept C162317418 @default.
- W2037250014 hasConcept C182704531 @default.
- W2037250014 hasConcept C2776403814 @default.
- W2037250014 hasConcept C2778024200 @default.
- W2037250014 hasConcept C2778163477 @default.
- W2037250014 hasConcept C2779134260 @default.
- W2037250014 hasConcept C2780394083 @default.
- W2037250014 hasConcept C2780827179 @default.
- W2037250014 hasConcept C4733338 @default.
- W2037250014 hasConcept C502942594 @default.
- W2037250014 hasConcept C54355233 @default.
- W2037250014 hasConcept C55493867 @default.
- W2037250014 hasConcept C57089818 @default.
- W2037250014 hasConcept C62746215 @default.
- W2037250014 hasConcept C71924100 @default.
- W2037250014 hasConcept C8415881 @default.
- W2037250014 hasConcept C86803240 @default.
- W2037250014 hasConceptScore W2037250014C102230213 @default.
- W2037250014 hasConceptScore W2037250014C104317684 @default.
- W2037250014 hasConceptScore W2037250014C118487528 @default.
- W2037250014 hasConceptScore W2037250014C134018914 @default.
- W2037250014 hasConceptScore W2037250014C141035611 @default.