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- W2037258723 abstract "Synergy can be assessed by a variety of microbiological techniques. Mathematical modelling of synergy data can accomplish similar results and may provide more information than currently available techniques. In this study a combination of 1/4 MIC of aztreonam (AZTR) and 1 MIC of ciprofloxacin (CIPX) showed synergy against Pseudomonas aeruginosa in killing curve studies (based on the two log different criteria) at the end of 24 h. However, re-growth was always observed even when bactericidal concentrations of antibiotics were present. The surviving organisms showed a two-fold increase of MIC to CIPX after the studies and this resistance was not reversible. A mathematical model to quantitatively describe this observation is proposed." @default.
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- W2037258723 date "2003-03-01" @default.
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- W2037258723 title "An approach for the evaluation of synergy between antimicrobials" @default.
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- W2037258723 doi "https://doi.org/10.1016/s0924-8579(02)00348-5" @default.
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