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• W2037262923 endingPage "16" @default.
• W2037262923 startingPage "9" @default.
• W2037262923 abstract "The effects of Fe(2+) and Fe(3+) on glycine-activated chloride current (IGly) were studied in rat isolated pyramidal hippocampal neurons using patch-clamp technique in whole-cell configuration. 25, 100 or 500 μM glycine was applied for 600 ms with 40s intervals. Fe(2+) and Fe(3+) were co-applied with glycine in the range of concentrations of 0.01-100 μM. We found that Fe(2+) and Fe(3+) affected IGly in a similar manner. Two types of effects of iron on IGly were observed. In low concentrations (0.1 μM) Fe ions caused an acceleration of the IGly desensitization, and the effect was more pronounced for IGly induced by 100 and 500 μM glycine than by 25 μM glycine. Higher Fe concentrations (1-100 μM) decreased the peak amplitude of IGly with weak influence on its kinetics. The values of IC50 of the effect were close to 10 μM for all glycine concentrations tested. The effect of iron on IGly peak did not depend on the membrane potential. This inhibition was noncompetitive and voltage-independent, suggesting that Fe ions do not exert their action on the agonist binding site of GlyRs or block the channel pore. An important characteristic of both effects of Fe was their progressive development during repetitive Fe applications (use-dependence). Our results suggest an existence of at least two binding sites for Fe ions which vary in affinity and mechanism of action, with the low-affinity site suppressing the activity of the high-affinity one. Physiological implication of our observations is that Fe ions in low micromolar concentrations can suppress tonic inhibition and cause hyperexcitability in hippocampus." @default.
• W2037262923 created "2016-06-24" @default.
• W2037262923 creator A5001702017 @default.
• W2037262923 creator A5054769129 @default.
• W2037262923 creator A5059060274 @default.
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• W2037262923 date "2015-06-01" @default.
• W2037262923 modified "2023-10-12" @default.
• W2037262923 title "Fe2+ and Fe3+ in micromolar concentrations modulate glycine-induced Cl− current in rat hippocampal neurons" @default.
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• W2037262923 doi "https://doi.org/10.1016/j.brainresbull.2015.04.004" @default.
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