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• W2037263003 abstract "Early human herpesvirus 6 (HHV6) reactivation after hematopoietic stem cell transplantation (HSCT) is associated with poor survival. We characterized HHV6 immuneresponses in HSCT patients during lymphopenia. Prospectively, HHV6 DNA-load was measured weekly by realtime-PCR. Numbers of IFNγ-producing HHV6-T-cells were retrospectively determined by enzyme-linked immunospot assay 2 months after HSCT. HHV6-specific T-cell proliferative capacity was analyzed with a newly developed assay using antigen-presenting autologous HHV6-infected PBMC. Fifty-six patients were included (median age 4.6 years; range 0.2–21.2 years). HHV6-reactivation occurred in 29/56 (52%) patients with a median time of 14 (range 1–41) days after HSCT. The median number of IFN-γ producing HHV6-specific T-cells at 2 months and the HHV6-specific CD8+ T-cell proliferative capacity at 6 months after HSCT was increased after HHV6-reactivation compared to non-reactivating patients (P = 0.006 and p = 0.019). In conclusion, HHV6-specific immuneresponses can be initiated during lymphopenia early after HSCT, which implicates a potential window for development of HHV6-specific (immuno)therapy." @default.
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• W2037263003 date "2012-09-01" @default.
• W2037263003 modified "2023-10-17" @default.
• W2037263003 title "First analysis of human herpesvirus 6T-cell responses: Specific boosting after HHV6 reactivation in stem cell transplantation recipients" @default.
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• W2037263003 doi "https://doi.org/10.1016/j.clim.2012.06.006" @default.
• W2037263003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22820131" @default.
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