FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037276912> ?p ?o ?g. }

• W2037276912 endingPage "226" @default.
• W2037276912 startingPage "220" @default.
• W2037276912 abstract "To assess the molecular basis of phenotypic alterations present in the gestational trophoblastic diseases (GTDs) and to identify genes whose expression is specifically associated with these placental proliferative disorders we performed differential display (DD) techniques. This strategy resulted in the isolation of four mitochondrial transcripts downregulated in benign, as well as in malignant, trophoblastic diseases encoding the cytochrome oxidase subunit I (COX I), the ATPase subunit 6, the 12S ribosomal RNA (12S rRNA) and the transfer RNA for phenylalanine (tRNA(Phe)). This expression pattern was confirmed by Northern blot in normal early placenta (NEP), complete hydatidiform mole (CHM), persistent gestational trophoblastic disease (PGTD) and the human choriocarcinoma derived cell line JEG-3. Quantification of mitochondrial DNA by dot blot indicated that these changes in expression were not associated with a significant alteration in the number of mitochondrial genome. In addition, a reduction in the mitochondrial transcription factor A (mtTFA) mRNA level was observed in benign as well as in malignant trophoblastic diseases in correlation with the decrease in the mitochondrial transcript levels. Furthermore, Western blot analysis for COX-I showed a close parallelism with the expression level of the cognate RNA. Taken together, these data demonstrate that a significant change in mitochondrial transcription is associated with the phenotypic alteration present in GTDs." @default.
• W2037276912 created "2016-06-24" @default.
• W2037276912 creator A5006057609 @default.
• W2037276912 creator A5016383984 @default.
• W2037276912 creator A5026273342 @default.
• W2037276912 creator A5043967154 @default.
• W2037276912 creator A5058715423 @default.
• W2037276912 creator A5076481951 @default.
• W2037276912 creator A5083088472 @default.
• W2037276912 date "2001-02-01" @default.
• W2037276912 modified "2023-10-02" @default.
• W2037276912 title "Altered Mitochondrial Gene Expression in Human Gestational Trophoblastic Diseases" @default.
• W2037276912 cites W1450184971 @default.
• W2037276912 cites W1528061714 @default.
• W2037276912 cites W1968197570 @default.
• W2037276912 cites W1978115920 @default.
• W2037276912 cites W1982573982 @default.
• W2037276912 cites W1986037296 @default.
• W2037276912 cites W1991703712 @default.
• W2037276912 cites W2017297899 @default.
• W2037276912 cites W2027916202 @default.
• W2037276912 cites W2032710745 @default.
• W2037276912 cites W2032965231 @default.
• W2037276912 cites W2043985611 @default.
• W2037276912 cites W2045948579 @default.
• W2037276912 cites W2074987564 @default.
• W2037276912 cites W2077311097 @default.
• W2037276912 cites W2077808648 @default.
• W2037276912 cites W2094002894 @default.
• W2037276912 cites W2098992864 @default.
• W2037276912 cites W2136021604 @default.
• W2037276912 cites W2158189832 @default.
• W2037276912 cites W2158714788 @default.
• W2037276912 cites W2321947794 @default.
• W2037276912 cites W2931627 @default.
• W2037276912 cites W4294216491 @default.
• W2037276912 cites W4319773333 @default.
• W2037276912 doi "https://doi.org/10.1053/plac.2000.0601" @default.
• W2037276912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11170827" @default.
• W2037276912 hasPublicationYear "2001" @default.
• W2037276912 type Work @default.
• W2037276912 sameAs 2037276912 @default.
• W2037276912 citedByCount "10" @default.
• W2037276912 countsByYear W20372769122020 @default.
• W2037276912 crossrefType "journal-article" @default.
• W2037276912 hasAuthorship W2037276912A5006057609 @default.
• W2037276912 hasAuthorship W2037276912A5016383984 @default.
• W2037276912 hasAuthorship W2037276912A5026273342 @default.
• W2037276912 hasAuthorship W2037276912A5043967154 @default.
• W2037276912 hasAuthorship W2037276912A5058715423 @default.
• W2037276912 hasAuthorship W2037276912A5076481951 @default.
• W2037276912 hasAuthorship W2037276912A5083088472 @default.
• W2037276912 hasConcept C104317684 @default.
• W2037276912 hasConcept C105580179 @default.
• W2037276912 hasConcept C133307689 @default.
• W2037276912 hasConcept C150194340 @default.
• W2037276912 hasConcept C153911025 @default.
• W2037276912 hasConcept C169415338 @default.
• W2037276912 hasConcept C172680121 @default.
• W2037276912 hasConcept C177707886 @default.
• W2037276912 hasConcept C24586158 @default.
• W2037276912 hasConcept C2776953305 @default.
• W2037276912 hasConcept C2777495146 @default.
• W2037276912 hasConcept C2779234561 @default.
• W2037276912 hasConcept C2780832733 @default.
• W2037276912 hasConcept C54355233 @default.
• W2037276912 hasConcept C86803240 @default.
• W2037276912 hasConceptScore W2037276912C104317684 @default.
• W2037276912 hasConceptScore W2037276912C105580179 @default.
• W2037276912 hasConceptScore W2037276912C133307689 @default.
• W2037276912 hasConceptScore W2037276912C150194340 @default.
• W2037276912 hasConceptScore W2037276912C153911025 @default.
• W2037276912 hasConceptScore W2037276912C169415338 @default.
• W2037276912 hasConceptScore W2037276912C172680121 @default.
• W2037276912 hasConceptScore W2037276912C177707886 @default.
• W2037276912 hasConceptScore W2037276912C24586158 @default.
• W2037276912 hasConceptScore W2037276912C2776953305 @default.
• W2037276912 hasConceptScore W2037276912C2777495146 @default.
• W2037276912 hasConceptScore W2037276912C2779234561 @default.
• W2037276912 hasConceptScore W2037276912C2780832733 @default.
• W2037276912 hasConceptScore W2037276912C54355233 @default.
• W2037276912 hasConceptScore W2037276912C86803240 @default.
• W2037276912 hasIssue "2-3" @default.
• W2037276912 hasLocation W20372769121 @default.
• W2037276912 hasLocation W20372769122 @default.
• W2037276912 hasOpenAccess W2037276912 @default.
• W2037276912 hasPrimaryLocation W20372769121 @default.
• W2037276912 hasRelatedWork W1530716184 @default.
• W2037276912 hasRelatedWork W1850799531 @default.
• W2037276912 hasRelatedWork W1972541767 @default.
• W2037276912 hasRelatedWork W1993478742 @default.
• W2037276912 hasRelatedWork W2093183948 @default.
• W2037276912 hasRelatedWork W2094008378 @default.
• W2037276912 hasRelatedWork W2116417071 @default.
• W2037276912 hasRelatedWork W2223718544 @default.
• W2037276912 hasRelatedWork W2344678176 @default.
• W2037276912 hasRelatedWork W4214714918 @default.
• W2037276912 hasVolume "22" @default.

• next