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- W2037279384 abstract "The tetracycline-based Tet-Off expression system has been used to analyze the effects of poliovirus protease 3Cpro on human cells. Stable HeLa cell clones that express this poliovirus protease under the control of an inducible, tightly regulated promoter were obtained. Tetracycline removal induces synthesis of 3C protease, followed by drastic morphological alterations and cellular death. Degradation of cellular DNA in nucleosomes and generation of apoptotic bodies are observed from the second day after 3Cpro induction. The cleavage of poly(ADP-ribose) polymerase, an enzyme involved in DNA repair, occurs after induction of 3Cpro, indicating caspase activation by this poliovirus protease. The 3Cpro-induced apoptosis is blocked by the caspase inhibitor z-VAD-fmk. Our findings suggest that the protease 3C is responsible for triggering apoptosis in poliovirus-infected cells by a mechanism that involves caspase activation." @default.
- W2037279384 created "2016-06-24" @default.
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- W2037279384 date "2000-01-01" @default.
- W2037279384 modified "2023-10-10" @default.
- W2037279384 title "Poliovirus Protease 3Cpro Kills Cells by Apoptosis" @default.
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- W2037279384 doi "https://doi.org/10.1006/viro.1999.0043" @default.
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