Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037288002> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2037288002 endingPage "113" @default.
- W2037288002 startingPage "105" @default.
- W2037288002 abstract "The effects of Brij 58 on microsome-mediated benzo[a]pyrene (BP)-metabolism were investigated. At a concentration of 0.01%, which did not decompose the microsomal mixed-function oxidase system, Brij 58 increased UDP-glucuronyl transferase activity on 3-hydroxy-BP to 560% of the control level. Quantitative changes of BP-metabolites by glucuronidation were found by high performance liquid chromatography. On incubation in the presence of UDP-glucuronic acid, the amounts of phenols decreased but the amounts of dihydrodiols did not change. Brij 58 enhanced the decrease in phenol metabolites. Unexpectedly, the binding of BP-metabolites to DNA was found to be higher in the presence of UDP-glucuronic acid, and Brij 58 also enhanced the binding in the presence of UDP-glucuronic acid. The ratio of bound adducts with BP-7,8-dihydrodiol-9,10-oxide to those with 9-hydroxy-BP-4,5-oxide, which were separated by Sephadex LH-20 column chromatography, was increased by UDP-glucuronic acid and further enhanced by Brij 58. These results are discussed in relation to the role of glucuronidation in metabolism of BP." @default.
- W2037288002 created "2016-06-24" @default.
- W2037288002 creator A5024928100 @default.
- W2037288002 creator A5046425489 @default.
- W2037288002 creator A5082678992 @default.
- W2037288002 date "1983-01-01" @default.
- W2037288002 modified "2023-09-24" @default.
- W2037288002 title "Effects of activation of UDP-glucuronyl transferase on metabolism of benzo(a)pyrene with rat liver microsomes." @default.
- W2037288002 cites W1513183869 @default.
- W2037288002 cites W1532309638 @default.
- W2037288002 cites W1541407096 @default.
- W2037288002 cites W1559871277 @default.
- W2037288002 cites W172739833 @default.
- W2037288002 cites W1855693255 @default.
- W2037288002 cites W1974648730 @default.
- W2037288002 cites W1986137403 @default.
- W2037288002 cites W1989616286 @default.
- W2037288002 cites W2018031821 @default.
- W2037288002 cites W2018196062 @default.
- W2037288002 cites W2054031732 @default.
- W2037288002 cites W2060102690 @default.
- W2037288002 cites W2064449868 @default.
- W2037288002 cites W2076343890 @default.
- W2037288002 cites W2080663656 @default.
- W2037288002 cites W2094715879 @default.
- W2037288002 cites W2116563078 @default.
- W2037288002 cites W2410151514 @default.
- W2037288002 cites W1554848998 @default.
- W2037288002 doi "https://doi.org/10.1248/bpb1978.6.105" @default.
- W2037288002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6306199" @default.
- W2037288002 hasPublicationYear "1983" @default.
- W2037288002 type Work @default.
- W2037288002 sameAs 2037288002 @default.
- W2037288002 citedByCount "1" @default.
- W2037288002 crossrefType "journal-article" @default.
- W2037288002 hasAuthorship W2037288002A5024928100 @default.
- W2037288002 hasAuthorship W2037288002A5046425489 @default.
- W2037288002 hasAuthorship W2037288002A5082678992 @default.
- W2037288002 hasBestOaLocation W20372880021 @default.
- W2037288002 hasConcept C100817775 @default.
- W2037288002 hasConcept C163994747 @default.
- W2037288002 hasConcept C178790620 @default.
- W2037288002 hasConcept C181199279 @default.
- W2037288002 hasConcept C185592680 @default.
- W2037288002 hasConcept C2776648616 @default.
- W2037288002 hasConcept C2777538855 @default.
- W2037288002 hasConcept C2777728882 @default.
- W2037288002 hasConcept C2778951431 @default.
- W2037288002 hasConcept C2779907587 @default.
- W2037288002 hasConcept C43617362 @default.
- W2037288002 hasConcept C55493867 @default.
- W2037288002 hasConcept C62231903 @default.
- W2037288002 hasConcept C87644729 @default.
- W2037288002 hasConceptScore W2037288002C100817775 @default.
- W2037288002 hasConceptScore W2037288002C163994747 @default.
- W2037288002 hasConceptScore W2037288002C178790620 @default.
- W2037288002 hasConceptScore W2037288002C181199279 @default.
- W2037288002 hasConceptScore W2037288002C185592680 @default.
- W2037288002 hasConceptScore W2037288002C2776648616 @default.
- W2037288002 hasConceptScore W2037288002C2777538855 @default.
- W2037288002 hasConceptScore W2037288002C2777728882 @default.
- W2037288002 hasConceptScore W2037288002C2778951431 @default.
- W2037288002 hasConceptScore W2037288002C2779907587 @default.
- W2037288002 hasConceptScore W2037288002C43617362 @default.
- W2037288002 hasConceptScore W2037288002C55493867 @default.
- W2037288002 hasConceptScore W2037288002C62231903 @default.
- W2037288002 hasConceptScore W2037288002C87644729 @default.
- W2037288002 hasIssue "2" @default.
- W2037288002 hasLocation W20372880021 @default.
- W2037288002 hasLocation W20372880022 @default.
- W2037288002 hasOpenAccess W2037288002 @default.
- W2037288002 hasPrimaryLocation W20372880021 @default.
- W2037288002 hasRelatedWork W136036310 @default.
- W2037288002 hasRelatedWork W1989387990 @default.
- W2037288002 hasRelatedWork W2017214690 @default.
- W2037288002 hasRelatedWork W2037288002 @default.
- W2037288002 hasRelatedWork W2070023275 @default.
- W2037288002 hasRelatedWork W2075829991 @default.
- W2037288002 hasRelatedWork W2087294636 @default.
- W2037288002 hasRelatedWork W2094715879 @default.
- W2037288002 hasRelatedWork W2362400370 @default.
- W2037288002 hasRelatedWork W4289969039 @default.
- W2037288002 hasVolume "6" @default.
- W2037288002 isParatext "false" @default.
- W2037288002 isRetracted "false" @default.
- W2037288002 magId "2037288002" @default.
- W2037288002 workType "article" @default.