FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037292778> ?p ?o ?g. }

• W2037292778 endingPage "237" @default.
• W2037292778 startingPage "230" @default.
• W2037292778 abstract "Pulsed electromagnetic fields (PEMF) have been shown to increase the rate of nerve regeneration. Transient post-transection loss of target-derived nerve growth factor (NGF) is one mechanism proposed to signal induction of early nerve regenerative events. We tested the hypothesis that PEMF alter levels of NGF activity and protein in injured nerve and/or dorsal root ganglia (DRG) during the first stages of regeneration (6–72 hr). Rats with a transection injury to the midthigh portion of the sciatic nerve on one side were exposed to PEMF or sham control PEMF for 4 hr/day for different time periods. NGF-like activity was determined in DRG, in 5-mm nerve segments proximal and distal to the transection site and in a corresponding 5-mm segment of the contralateral nonoperated nerve. NGF-like activity of coded tissue samples was measured in a blinded fashion using the chick DRG sensory neuron bioassay. Overall, PEMF caused a significant decrease in NGF-like activity in nerve tissue (P < 0.02, repeated measures analysis of variance, ANOVA) with decreases evident in proximal, distal, and contralateral nonoperated nerve. Unexpectedly, transection was also found to cause a significant (P = 0.001) 2-fold increase in DRG NGF-like activity between 6 and 24 hr postinjury in contralateral but not ipsilateral DRG. PEMF also reduced NGF-like activity in DRG, although this decrease did not reach statistical significance. Assessment of the same nerve and DRG samples using ELISA and NGF-specific antibodies confirmed an overall significant (P < 0.001) decrease in NGF levels in PEMF-treated nerve tissue, while no decrease was detected in DRG or in nerve samples harvested from PEMF-treated uninjured rats. These findings demonstrate that PEMF can affect growth factor activity and levels, and raise the possibility that PEMF might promote nerve regeneration by amplifying the early postinjury decline in NGF activity. J. Neurosci. Res. 55:230–237, 1999. Published 1999 Wiley-Liss, Inc." @default.
• W2037292778 created "2016-06-24" @default.
• W2037292778 creator A5011436583 @default.
• W2037292778 creator A5019824956 @default.
• W2037292778 creator A5051257507 @default.
• W2037292778 creator A5059895555 @default.
• W2037292778 creator A5079616106 @default.
• W2037292778 creator A5083277385 @default.
• W2037292778 creator A5085582797 @default.
• W2037292778 creator A5088508476 @default.
• W2037292778 date "1999-01-15" @default.
• W2037292778 modified "2023-10-16" @default.
• W2037292778 title "Electromagnetic fields influence NGF activity and levels following sciatic nerve transection" @default.
• W2037292778 cites W165292829 @default.
• W2037292778 cites W1959834892 @default.
• W2037292778 cites W1963870770 @default.
• W2037292778 cites W1966250971 @default.
• W2037292778 cites W1977209656 @default.
• W2037292778 cites W1979253054 @default.
• W2037292778 cites W1981065627 @default.
• W2037292778 cites W1981238039 @default.
• W2037292778 cites W1981691591 @default.
• W2037292778 cites W1983738760 @default.
• W2037292778 cites W1986662264 @default.
• W2037292778 cites W1990018875 @default.
• W2037292778 cites W1994973260 @default.
• W2037292778 cites W2000140015 @default.
• W2037292778 cites W2000367231 @default.
• W2037292778 cites W2001148555 @default.
• W2037292778 cites W2006279071 @default.
• W2037292778 cites W2019579305 @default.
• W2037292778 cites W2021054927 @default.
• W2037292778 cites W2024976795 @default.
• W2037292778 cites W2028892517 @default.
• W2037292778 cites W2029187641 @default.
• W2037292778 cites W2033714548 @default.
• W2037292778 cites W2034127040 @default.
• W2037292778 cites W2042647735 @default.
• W2037292778 cites W2043344536 @default.
• W2037292778 cites W2047857335 @default.
• W2037292778 cites W2054113611 @default.
• W2037292778 cites W2063525911 @default.
• W2037292778 cites W2083886620 @default.
• W2037292778 cites W2099846952 @default.
• W2037292778 cites W2113723285 @default.
• W2037292778 cites W2118272847 @default.
• W2037292778 cites W2126961438 @default.
• W2037292778 cites W2130396588 @default.
• W2037292778 cites W2139521183 @default.
• W2037292778 cites W2139696718 @default.
• W2037292778 cites W2165161781 @default.
• W2037292778 cites W2210211738 @default.
• W2037292778 cites W2396748657 @default.
• W2037292778 cites W4299810211 @default.
• W2037292778 doi "https://doi.org/10.1002/(sici)1097-4547(19990115)55:2<230::aid-jnr10>3.0.co;2-3" @default.
• W2037292778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9972825" @default.
• W2037292778 hasPublicationYear "1999" @default.
• W2037292778 type Work @default.
• W2037292778 sameAs 2037292778 @default.
• W2037292778 citedByCount "55" @default.
• W2037292778 countsByYear W20372927782012 @default.
• W2037292778 countsByYear W20372927782013 @default.
• W2037292778 countsByYear W20372927782014 @default.
• W2037292778 countsByYear W20372927782015 @default.
• W2037292778 countsByYear W20372927782016 @default.
• W2037292778 countsByYear W20372927782017 @default.
• W2037292778 countsByYear W20372927782018 @default.
• W2037292778 countsByYear W20372927782019 @default.
• W2037292778 countsByYear W20372927782020 @default.
• W2037292778 countsByYear W20372927782021 @default.
• W2037292778 countsByYear W20372927782023 @default.
• W2037292778 crossrefType "journal-article" @default.
• W2037292778 hasAuthorship W2037292778A5011436583 @default.
• W2037292778 hasAuthorship W2037292778A5019824956 @default.
• W2037292778 hasAuthorship W2037292778A5051257507 @default.
• W2037292778 hasAuthorship W2037292778A5059895555 @default.
• W2037292778 hasAuthorship W2037292778A5079616106 @default.
• W2037292778 hasAuthorship W2037292778A5083277385 @default.
• W2037292778 hasAuthorship W2037292778A5085582797 @default.
• W2037292778 hasAuthorship W2037292778A5088508476 @default.
• W2037292778 hasConcept C105702510 @default.
• W2037292778 hasConcept C126322002 @default.
• W2037292778 hasConcept C170493617 @default.
• W2037292778 hasConcept C2775991916 @default.
• W2037292778 hasConcept C2778423431 @default.
• W2037292778 hasConcept C2781149210 @default.
• W2037292778 hasConcept C42219234 @default.
• W2037292778 hasConcept C71924100 @default.
• W2037292778 hasConcept C99476002 @default.
• W2037292778 hasConceptScore W2037292778C105702510 @default.
• W2037292778 hasConceptScore W2037292778C126322002 @default.
• W2037292778 hasConceptScore W2037292778C170493617 @default.
• W2037292778 hasConceptScore W2037292778C2775991916 @default.
• W2037292778 hasConceptScore W2037292778C2778423431 @default.
• W2037292778 hasConceptScore W2037292778C2781149210 @default.
• W2037292778 hasConceptScore W2037292778C42219234 @default.
• W2037292778 hasConceptScore W2037292778C71924100 @default.
• W2037292778 hasConceptScore W2037292778C99476002 @default.

• next