Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037293835> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2037293835 abstract "We recently demonstrated that anti-CD47 monoclonal antibodies (mAbs) promote the phagocytosis of solid tumor cells in vitro and inhibit the growth and metastasis of human solid tumors in xenotransplantation models (1). We also observed a significant inhibition of tumor growth in a syngeneic mouse tumor model treated with MIAP410, an anti-mouse CD47 (mCD47) mAb. In contrast, a second blocking anti-mCD47 mAb (MIAP301) produced a moderate, yet insignificant, antitumor effect. The reasons for the lack of MIAP301 activity in this model are unclear, but could simply be due to the statistical power of the study.MIAP410 was previously reported to not block mCD47–mSIRPα interactions (2). In contrast, we have determined that MIAP410 does block mCD47–mSIRPα interactions (Fig. 1). This discrepancy may be attributable to the N-terminal GST-CD47 fusion protein used in the prior blocking assays (2). Polypeptide additions at the N terminus of CD47 prevent the N-terminal glutamine residue of CD47 from forming pyroglutamic acid. As seen in the SIRPα–CD47 complex crystal structure (3), this residue is critical … [↵][1]1To whom correspondence should be addressed. E-mail: irv{at}stanford.edu. [1]: #xref-corresp-1-1" @default.
- W2037293835 created "2016-06-24" @default.
- W2037293835 creator A5009306261 @default.
- W2037293835 creator A5028357906 @default.
- W2037293835 creator A5037238797 @default.
- W2037293835 creator A5058232466 @default.
- W2037293835 creator A5082894731 @default.
- W2037293835 date "2012-08-24" @default.
- W2037293835 modified "2023-09-25" @default.
- W2037293835 title "Reply to Soto-Pantoja et al. and Zhao et al.: Targeting CD47 on human solid tumors" @default.
- W2037293835 cites W1964738368 @default.
- W2037293835 cites W1964791394 @default.
- W2037293835 cites W1966217032 @default.
- W2037293835 cites W1981878585 @default.
- W2037293835 cites W2013292757 @default.
- W2037293835 cites W2015532923 @default.
- W2037293835 cites W2028407058 @default.
- W2037293835 cites W2044062220 @default.
- W2037293835 cites W2091133773 @default.
- W2037293835 cites W2106545303 @default.
- W2037293835 cites W2106905367 @default.
- W2037293835 doi "https://doi.org/10.1073/pnas.1209743109" @default.
- W2037293835 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3479530" @default.
- W2037293835 hasPublicationYear "2012" @default.
- W2037293835 type Work @default.
- W2037293835 sameAs 2037293835 @default.
- W2037293835 citedByCount "5" @default.
- W2037293835 countsByYear W20372938352015 @default.
- W2037293835 countsByYear W20372938352017 @default.
- W2037293835 countsByYear W20372938352019 @default.
- W2037293835 countsByYear W20372938352020 @default.
- W2037293835 crossrefType "journal-article" @default.
- W2037293835 hasAuthorship W2037293835A5009306261 @default.
- W2037293835 hasAuthorship W2037293835A5028357906 @default.
- W2037293835 hasAuthorship W2037293835A5037238797 @default.
- W2037293835 hasAuthorship W2037293835A5058232466 @default.
- W2037293835 hasAuthorship W2037293835A5082894731 @default.
- W2037293835 hasBestOaLocation W20372938351 @default.
- W2037293835 hasConcept C153911025 @default.
- W2037293835 hasConcept C185592680 @default.
- W2037293835 hasConcept C86803240 @default.
- W2037293835 hasConceptScore W2037293835C153911025 @default.
- W2037293835 hasConceptScore W2037293835C185592680 @default.
- W2037293835 hasConceptScore W2037293835C86803240 @default.
- W2037293835 hasIssue "42" @default.
- W2037293835 hasLocation W20372938351 @default.
- W2037293835 hasLocation W20372938352 @default.
- W2037293835 hasLocation W20372938353 @default.
- W2037293835 hasOpenAccess W2037293835 @default.
- W2037293835 hasPrimaryLocation W20372938351 @default.
- W2037293835 hasRelatedWork W1531601525 @default.
- W2037293835 hasRelatedWork W1990781990 @default.
- W2037293835 hasRelatedWork W2314643286 @default.
- W2037293835 hasRelatedWork W2344122601 @default.
- W2037293835 hasRelatedWork W2606230654 @default.
- W2037293835 hasRelatedWork W2607424097 @default.
- W2037293835 hasRelatedWork W2748952813 @default.
- W2037293835 hasRelatedWork W2899084033 @default.
- W2037293835 hasRelatedWork W2948807893 @default.
- W2037293835 hasRelatedWork W2778153218 @default.
- W2037293835 hasVolume "109" @default.
- W2037293835 isParatext "false" @default.
- W2037293835 isRetracted "false" @default.
- W2037293835 magId "2037293835" @default.
- W2037293835 workType "article" @default.