Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037296911> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2037296911 endingPage "666" @default.
- W2037296911 startingPage "660" @default.
- W2037296911 abstract "The area under the concentration time curve (AUC) for oral tacrolimus (FK) may provide a more precise model for FK monitoring after renal transplantation. The purpose of this study is to identify a simple, cost-effective method for predicting FK AUC. FK concentrations were measured at 0, 1, 2, 4, 6, 8, and 12 hours after the morning dose. The predicted AUCs (AUC(p)s) derived from regression equations were used to estimate the actual 12-hour AUCs (AUC(12)s). The relationship between AUC(p) and AUC(12) was validated by determining the coefficient of multiple determination (R(2)), percentage of prediction error (PE%), and percentage of absolute prediction error (APE%). Eighteen stable Oriental renal transplant recipients (9 men, 9 women) with a mean age of 42.6 +/- 6 years and mean body weight of 62.7 +/- 10 kg were recruited for the study. The FK AUC(12), trough, 2-hour, and 4-hour concentrations were 125 +/- 24 h. ng/mL (range, 87.7 to 181.9 h. ng/mL), 6 +/- 1.3 ng/mL, 18.1 +/- 4.7 ng/mL, and 11 +/- 2.4 ng/mL, respectively. Trough FK concentration did not have a significant correlation with AUC(12) (r = 0.34; P = 0.17). AUC(p) obtained by a two-time point regression equation using 2-hour (C2) and 4-hour (C4) FK concentrations: (AUC(P) = 16.2 + 2.4*C2 + 5.9*C4) obtained an R(2), PE%, and APE% of 0.93, -0.2% +/- 5.2% (range, -13% to 9.3%), and 3. 6% +/- 3.7% (range, 0.02% to 13%), respectively. We conclude that a two-point sampling method using C2 and C4 may be a more cost-effective FK monitoring strategy than morning FK trough levels in transplant recipients." @default.
- W2037296911 created "2016-06-24" @default.
- W2037296911 creator A5009236231 @default.
- W2037296911 creator A5023569287 @default.
- W2037296911 creator A5047640717 @default.
- W2037296911 creator A5056340630 @default.
- W2037296911 date "2000-04-01" @default.
- W2037296911 modified "2023-09-30" @default.
- W2037296911 title "Abbreviated tacrolimus area-under-the-curve monitoring for renal transplant recipients" @default.
- W2037296911 cites W1964887178 @default.
- W2037296911 cites W1981801952 @default.
- W2037296911 cites W1985179193 @default.
- W2037296911 cites W2003143162 @default.
- W2037296911 cites W2025752875 @default.
- W2037296911 cites W2027774666 @default.
- W2037296911 cites W2031731525 @default.
- W2037296911 cites W2040778421 @default.
- W2037296911 cites W2048384708 @default.
- W2037296911 cites W2085415545 @default.
- W2037296911 cites W2094944937 @default.
- W2037296911 cites W2135731448 @default.
- W2037296911 cites W2253179440 @default.
- W2037296911 cites W2324012345 @default.
- W2037296911 cites W2329449767 @default.
- W2037296911 cites W4244016730 @default.
- W2037296911 cites W4250690782 @default.
- W2037296911 doi "https://doi.org/10.1016/s0272-6386(00)70013-8" @default.
- W2037296911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10739787" @default.
- W2037296911 hasPublicationYear "2000" @default.
- W2037296911 type Work @default.
- W2037296911 sameAs 2037296911 @default.
- W2037296911 citedByCount "117" @default.
- W2037296911 countsByYear W20372969112012 @default.
- W2037296911 countsByYear W20372969112013 @default.
- W2037296911 countsByYear W20372969112014 @default.
- W2037296911 countsByYear W20372969112015 @default.
- W2037296911 countsByYear W20372969112016 @default.
- W2037296911 countsByYear W20372969112017 @default.
- W2037296911 countsByYear W20372969112018 @default.
- W2037296911 countsByYear W20372969112019 @default.
- W2037296911 countsByYear W20372969112020 @default.
- W2037296911 countsByYear W20372969112021 @default.
- W2037296911 countsByYear W20372969112022 @default.
- W2037296911 countsByYear W20372969112023 @default.
- W2037296911 crossrefType "journal-article" @default.
- W2037296911 hasAuthorship W2037296911A5009236231 @default.
- W2037296911 hasAuthorship W2037296911A5023569287 @default.
- W2037296911 hasAuthorship W2037296911A5047640717 @default.
- W2037296911 hasAuthorship W2037296911A5056340630 @default.
- W2037296911 hasConcept C112705442 @default.
- W2037296911 hasConcept C126322002 @default.
- W2037296911 hasConcept C126894567 @default.
- W2037296911 hasConcept C19720800 @default.
- W2037296911 hasConcept C2909675724 @default.
- W2037296911 hasConcept C2910800852 @default.
- W2037296911 hasConcept C2911091166 @default.
- W2037296911 hasConcept C2992666275 @default.
- W2037296911 hasConcept C3020225094 @default.
- W2037296911 hasConcept C31785415 @default.
- W2037296911 hasConcept C71924100 @default.
- W2037296911 hasConcept C76318530 @default.
- W2037296911 hasConceptScore W2037296911C112705442 @default.
- W2037296911 hasConceptScore W2037296911C126322002 @default.
- W2037296911 hasConceptScore W2037296911C126894567 @default.
- W2037296911 hasConceptScore W2037296911C19720800 @default.
- W2037296911 hasConceptScore W2037296911C2909675724 @default.
- W2037296911 hasConceptScore W2037296911C2910800852 @default.
- W2037296911 hasConceptScore W2037296911C2911091166 @default.
- W2037296911 hasConceptScore W2037296911C2992666275 @default.
- W2037296911 hasConceptScore W2037296911C3020225094 @default.
- W2037296911 hasConceptScore W2037296911C31785415 @default.
- W2037296911 hasConceptScore W2037296911C71924100 @default.
- W2037296911 hasConceptScore W2037296911C76318530 @default.
- W2037296911 hasIssue "4" @default.
- W2037296911 hasLocation W20372969111 @default.
- W2037296911 hasLocation W20372969112 @default.
- W2037296911 hasOpenAccess W2037296911 @default.
- W2037296911 hasPrimaryLocation W20372969111 @default.
- W2037296911 hasRelatedWork W1984291491 @default.
- W2037296911 hasRelatedWork W2011948815 @default.
- W2037296911 hasRelatedWork W2037296911 @default.
- W2037296911 hasRelatedWork W2047567344 @default.
- W2037296911 hasRelatedWork W2075552207 @default.
- W2037296911 hasRelatedWork W2082242631 @default.
- W2037296911 hasRelatedWork W2092205283 @default.
- W2037296911 hasRelatedWork W2316567816 @default.
- W2037296911 hasRelatedWork W2792894492 @default.
- W2037296911 hasRelatedWork W87595000 @default.
- W2037296911 hasVolume "35" @default.
- W2037296911 isParatext "false" @default.
- W2037296911 isRetracted "false" @default.
- W2037296911 magId "2037296911" @default.
- W2037296911 workType "article" @default.