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- W2037311267 abstract "The biological activities of human IgG antibodies predominantly rely on a family of receptors for the Fc portion of IgG, FcγRs: FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA, FcγRIIIB, FcRL5, FcRn, and TRIM21. All FcγRs bind IgG at the cell surface, except FcRn and TRIM21 that bind IgG once internalized. The affinity of FcγRs for IgG is determined by polymorphisms of human FcγRs and ranges from 2 × 10(4) to 8 × 10(7) M(-1). The biological functions of FcγRs extend from cellular activation or inhibition, IgG-internalization/endocytosis/phagocytosis to IgG transport and recycling. This review focuses on human FcγRs and intends to present an overview of the current understanding of how these receptors may contribute to various pathologies. It will define FcγRs and their polymorphic variants, their affinity for human IgG subclasses, and review the associations found between FcγR polymorphisms and human pathologies. It will also describe the human FcγR-transgenic mice that have been used to study the role of these receptors in autoimmune, inflammatory, and allergic disease models." @default.
- W2037311267 created "2016-06-24" @default.
- W2037311267 creator A5029545795 @default.
- W2037311267 creator A5039719011 @default.
- W2037311267 creator A5047484390 @default.
- W2037311267 creator A5075121437 @default.
- W2037311267 date "2014-05-30" @default.
- W2037311267 modified "2023-10-17" @default.
- W2037311267 title "Contribution of Human FcγRs to Disease with Evidence from Human Polymorphisms and Transgenic Animal Studies" @default.
- W2037311267 cites W1481966022 @default.
- W2037311267 cites W1482082625 @default.
- W2037311267 cites W1482406645 @default.
- W2037311267 cites W14894812 @default.
- W2037311267 cites W1491395810 @default.
- W2037311267 cites W1527622313 @default.
- W2037311267 cites W1559928694 @default.
- W2037311267 cites W1580163717 @default.
- W2037311267 cites W1587015226 @default.
- W2037311267 cites W1608772801 @default.
- W2037311267 cites W1622362352 @default.
- W2037311267 cites W1636327287 @default.
- W2037311267 cites W1650686523 @default.
- W2037311267 cites W1686249017 @default.
- W2037311267 cites W1892239264 @default.
- W2037311267 cites W1893571729 @default.
- W2037311267 cites W1895905470 @default.
- W2037311267 cites W1914573154 @default.
- W2037311267 cites W1950593974 @default.
- W2037311267 cites W1964162643 @default.
- W2037311267 cites W1964377755 @default.
- W2037311267 cites W1965696287 @default.
- W2037311267 cites W1967581879 @default.
- W2037311267 cites W1967761542 @default.
- W2037311267 cites W1970963947 @default.
- W2037311267 cites W1975039969 @default.
- W2037311267 cites W1979381758 @default.
- W2037311267 cites W1982861708 @default.
- W2037311267 cites W1984413085 @default.
- W2037311267 cites W1985701112 @default.
- W2037311267 cites W1987471547 @default.
- W2037311267 cites W1989236531 @default.
- W2037311267 cites W1991354178 @default.
- W2037311267 cites W1991656907 @default.
- W2037311267 cites W1995250806 @default.
- W2037311267 cites W1999157320 @default.
- W2037311267 cites W2003514025 @default.
- W2037311267 cites W2003630446 @default.
- W2037311267 cites W2005098984 @default.
- W2037311267 cites W2011984976 @default.
- W2037311267 cites W2012967644 @default.
- W2037311267 cites W2013523251 @default.
- W2037311267 cites W2014291562 @default.
- W2037311267 cites W2017014846 @default.
- W2037311267 cites W2017316020 @default.
- W2037311267 cites W2022754521 @default.
- W2037311267 cites W2024737355 @default.
- W2037311267 cites W2024972268 @default.
- W2037311267 cites W2029993165 @default.
- W2037311267 cites W2033647820 @default.
- W2037311267 cites W2033806521 @default.
- W2037311267 cites W2034408745 @default.
- W2037311267 cites W2036059928 @default.
- W2037311267 cites W2038204022 @default.
- W2037311267 cites W2040648595 @default.
- W2037311267 cites W2044360617 @default.
- W2037311267 cites W2044732378 @default.
- W2037311267 cites W2044869115 @default.
- W2037311267 cites W2048998302 @default.
- W2037311267 cites W2049247148 @default.
- W2037311267 cites W2050400262 @default.
- W2037311267 cites W2050926505 @default.
- W2037311267 cites W2052172534 @default.
- W2037311267 cites W2052746029 @default.
- W2037311267 cites W2053142169 @default.
- W2037311267 cites W2053313205 @default.
- W2037311267 cites W2054178734 @default.
- W2037311267 cites W2055935085 @default.
- W2037311267 cites W2056730299 @default.
- W2037311267 cites W2057005399 @default.
- W2037311267 cites W2057745345 @default.
- W2037311267 cites W2063145045 @default.
- W2037311267 cites W2064640882 @default.
- W2037311267 cites W2069069999 @default.
- W2037311267 cites W2069545269 @default.
- W2037311267 cites W2070900214 @default.
- W2037311267 cites W2071843728 @default.
- W2037311267 cites W2072577743 @default.
- W2037311267 cites W2074111056 @default.
- W2037311267 cites W2074293953 @default.
- W2037311267 cites W2075895560 @default.
- W2037311267 cites W2075901113 @default.
- W2037311267 cites W2076891149 @default.
- W2037311267 cites W2077383347 @default.
- W2037311267 cites W2078495995 @default.
- W2037311267 cites W2079349083 @default.
- W2037311267 cites W2079579628 @default.
- W2037311267 cites W2080077971 @default.
- W2037311267 cites W2081324045 @default.
- W2037311267 cites W2086853973 @default.
- W2037311267 cites W2086968511 @default.