Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037312151> ?p ?o ?g. }
- W2037312151 endingPage "3039" @default.
- W2037312151 startingPage "3032" @default.
- W2037312151 abstract "Background and Purpose— Despite the availability of results from multiple newer clinical trials and changing healthcare costs, the cost-effectiveness of recombinant tissue-type plasminogen activator (r-tPA) for treatment of acute ischemic stroke within 0 to 3 hours of symptom onset was last evaluated in 1998 for the United States Using current evidence, we evaluate the long-term cost-effectiveness of r-tPA administered 0 to 3 hours after acute ischemic stroke onset versus no r-tPA. Methods— A disease-based decision model to project lifetime outcomes of patients after acute ischemic stroke by r-tPA treatment status from the US payer perspective was developed. Model inputs were derived from a recent meta-analysis of r-tPA trials, cohort studies, and health state preference studies. Cost data, inflated to 2013 dollars, were based on drug wholesale acquisition cost and the literature. To compare r-tPA to no r-tPA, we calculated incremental total direct costs, incremental quality-adjusted life years, and incremental cost-effectiveness ratios. We performed 1-way and probabilistic sensitivity analyses to evaluate uncertainty in the results. Results— r-tPA resulted in a gain of 0.39 quality-adjusted life years (95% confidence range, 0.16–0.66) on average per patient and a lifetime cost-saving of $25 000 (95% confidence range, −$42 500 to −$11 000) compared with no r-tPA. In probabilistic sensitivity analyses, r-tPA was dominant compared with no r-tPA in ≈100% of simulations. The model was sensitive to inputs for r-tPA efficacy, healthcare costs for disabled patients, mortality rates for disabled and nondisabled patients, and quality of life estimates. Conclusions— Our analysis supports earlier economic evaluations that r-tPA is a cost-effective method to treat stroke. Appropriate use of r-tPA should be prioritized nationally." @default.
- W2037312151 created "2016-06-24" @default.
- W2037312151 creator A5010801722 @default.
- W2037312151 creator A5021113768 @default.
- W2037312151 creator A5034973763 @default.
- W2037312151 creator A5041518689 @default.
- W2037312151 creator A5072015843 @default.
- W2037312151 creator A5085042140 @default.
- W2037312151 creator A5085357003 @default.
- W2037312151 date "2014-10-01" @default.
- W2037312151 modified "2023-10-14" @default.
- W2037312151 title "Cost-Effectiveness of Recombinant Tissue-Type Plasminogen Activator Within 3 Hours of Acute Ischemic Stroke" @default.
- W2037312151 cites W119839859 @default.
- W2037312151 cites W1530016566 @default.
- W2037312151 cites W179951671 @default.
- W2037312151 cites W1966744791 @default.
- W2037312151 cites W1970409887 @default.
- W2037312151 cites W1971890855 @default.
- W2037312151 cites W1977818483 @default.
- W2037312151 cites W1980187445 @default.
- W2037312151 cites W1983567452 @default.
- W2037312151 cites W1985841117 @default.
- W2037312151 cites W1993614294 @default.
- W2037312151 cites W1997064745 @default.
- W2037312151 cites W2002771148 @default.
- W2037312151 cites W2009526873 @default.
- W2037312151 cites W2011289782 @default.
- W2037312151 cites W2012154384 @default.
- W2037312151 cites W2013329800 @default.
- W2037312151 cites W2018803785 @default.
- W2037312151 cites W2030472502 @default.
- W2037312151 cites W2031765536 @default.
- W2037312151 cites W2032509976 @default.
- W2037312151 cites W2044705878 @default.
- W2037312151 cites W2050735040 @default.
- W2037312151 cites W2051777375 @default.
- W2037312151 cites W2059135872 @default.
- W2037312151 cites W2061382057 @default.
- W2037312151 cites W2062642961 @default.
- W2037312151 cites W2063544001 @default.
- W2037312151 cites W2063801052 @default.
- W2037312151 cites W2066157763 @default.
- W2037312151 cites W2070896918 @default.
- W2037312151 cites W2080196819 @default.
- W2037312151 cites W2081991033 @default.
- W2037312151 cites W2095783086 @default.
- W2037312151 cites W2097161348 @default.
- W2037312151 cites W2097376540 @default.
- W2037312151 cites W2098032054 @default.
- W2037312151 cites W2104634293 @default.
- W2037312151 cites W2109780560 @default.
- W2037312151 cites W2112930056 @default.
- W2037312151 cites W2117582884 @default.
- W2037312151 cites W2120648762 @default.
- W2037312151 cites W2121109761 @default.
- W2037312151 cites W2127179948 @default.
- W2037312151 cites W2127272421 @default.
- W2037312151 cites W2130483595 @default.
- W2037312151 cites W2132929868 @default.
- W2037312151 cites W2143770483 @default.
- W2037312151 cites W2144355560 @default.
- W2037312151 cites W2148132508 @default.
- W2037312151 cites W2149701121 @default.
- W2037312151 cites W2154146881 @default.
- W2037312151 cites W2155477484 @default.
- W2037312151 cites W2159233098 @default.
- W2037312151 cites W2171165037 @default.
- W2037312151 cites W2292308933 @default.
- W2037312151 cites W2614781785 @default.
- W2037312151 cites W4211201192 @default.
- W2037312151 cites W4252288399 @default.
- W2037312151 cites W4292329040 @default.
- W2037312151 cites W4292339830 @default.
- W2037312151 doi "https://doi.org/10.1161/strokeaha.114.005852" @default.
- W2037312151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25190439" @default.
- W2037312151 hasPublicationYear "2014" @default.
- W2037312151 type Work @default.
- W2037312151 sameAs 2037312151 @default.
- W2037312151 citedByCount "54" @default.
- W2037312151 countsByYear W20373121512015 @default.
- W2037312151 countsByYear W20373121512016 @default.
- W2037312151 countsByYear W20373121512017 @default.
- W2037312151 countsByYear W20373121512018 @default.
- W2037312151 countsByYear W20373121512019 @default.
- W2037312151 countsByYear W20373121512020 @default.
- W2037312151 countsByYear W20373121512021 @default.
- W2037312151 countsByYear W20373121512022 @default.
- W2037312151 countsByYear W20373121512023 @default.
- W2037312151 crossrefType "journal-article" @default.
- W2037312151 hasAuthorship W2037312151A5010801722 @default.
- W2037312151 hasAuthorship W2037312151A5021113768 @default.
- W2037312151 hasAuthorship W2037312151A5034973763 @default.
- W2037312151 hasAuthorship W2037312151A5041518689 @default.
- W2037312151 hasAuthorship W2037312151A5072015843 @default.
- W2037312151 hasAuthorship W2037312151A5085042140 @default.
- W2037312151 hasAuthorship W2037312151A5085357003 @default.
- W2037312151 hasConcept C112930515 @default.
- W2037312151 hasConcept C126322002 @default.