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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037312593> ?p ?o ?g. }

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• W2037312593 abstract "The cerebellar cortex is implicated in the learning of complex motor skills. This learning may require synaptic remodeling of Purkinje cell inputs. An extracellular serine protease, tissue plasminogen activator (tPA), is involved in remodeling various nonneural tissues and is associated with developing and regenerating neurons. In situ hybridization showed that expression of tPA messenger RNA was increased in the Purkinje neurons of rats within an hour of their being trained for a complex motor task. Antibody to tPA also showed the induction of tPA protein associated with cerebellar Purkinje cells. Thus, the induction of tPA during motor learning may play a role in activity-dependent synaptic plasticity." @default.
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• W2037312593 date "1995-12-22" @default.
• W2037312593 modified "2023-10-14" @default.
• W2037312593 title "Tissue Plasminogen Activator Induction in Purkinje Neurons After Cerebellar Motor Learning" @default.
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• W2037312593 doi "https://doi.org/10.1126/science.270.5244.1992" @default.
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