FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037322885> ?p ?o ?g. }

• W2037322885 endingPage "1339" @default.
• W2037322885 startingPage "1330" @default.
• W2037322885 abstract "PurposeTo investigate the optic nerve and macular morphology in patients with optic nerve hypoplasia (ONH) using spectral-domain optical coherence tomography (SD OCT).DesignProspective, cross-sectional, observational study.SubjectsA total of 16 participants with ONH (10 female and 6 male; mean age, 17.2 years; 6 bilateral involvement) and 32 gender-, age-, ethnicity-, and refraction-matched healthy controls.MethodsHigh-resolution SD OCT (Copernicus [Optopol Technology S.A., Zawiercie, Poland], 3 μm resolution) and handheld SD OCT (Bioptigen Inc [Research Triangle Park, NC], 2.6 μm resolution) devices were used to acquire horizontal scans through the center of the optic disc and macula.Main Outcome MeasuresHorizontal optic disc/cup and rim diameters, cup depth, peripapillary retinal nerve fiber layer (RNFL), and thickness of individual retinal layers in participants with ONH and in controls.ResultsPatients with ONH had significantly smaller discs (P < 0.03 and P < 0.001 compared with unaffected eye and healthy controls, respectively), horizontal cup diameter (P < 0.02 for both), and cup depth (P < 0.02 and P < 0.01, respectively). In the macula, significantly thinner RNFL (nasally), ganglion cell layer (GCL) (nasally and temporally), inner plexiform layer (IPL) (nasally), outer nuclear layer (ONL) (nasally), and inner segment (centrally and temporally) were found in patients with ONH compared with the control group (P < 0.05 for all comparisons). Continuation of significantly thicker GCL, IPL, and outer plexiform layer in the central retinal area (i.e., foveal hypoplasia) was found in more than 80% of patients with ONH. Clinically unaffected fellow eyes of patients with ONH showed mild features of underdevelopment. Visual acuity and presence of septo-optic dysplasia were associated with changes in GCL and IPL. Sensitivity and specificity for the detection of ONH based on disc and retinal optical coherence tomography (OCT) parameters were >80%.ConclusionsOur study provides evidence of retinal changes in ONH. In addition to thinning of retina layers mainly involving the RNFL and GCL, signs reminiscent of foveal hypoplasia were observed in patients with ONH. Optic nerve and foveal parameters measured using OCT showed high sensitivity and specificity for detecting ONH, demonstrating their useful for clinical diagnosis. To investigate the optic nerve and macular morphology in patients with optic nerve hypoplasia (ONH) using spectral-domain optical coherence tomography (SD OCT). Prospective, cross-sectional, observational study. A total of 16 participants with ONH (10 female and 6 male; mean age, 17.2 years; 6 bilateral involvement) and 32 gender-, age-, ethnicity-, and refraction-matched healthy controls. High-resolution SD OCT (Copernicus [Optopol Technology S.A., Zawiercie, Poland], 3 μm resolution) and handheld SD OCT (Bioptigen Inc [Research Triangle Park, NC], 2.6 μm resolution) devices were used to acquire horizontal scans through the center of the optic disc and macula. Horizontal optic disc/cup and rim diameters, cup depth, peripapillary retinal nerve fiber layer (RNFL), and thickness of individual retinal layers in participants with ONH and in controls. Patients with ONH had significantly smaller discs (P < 0.03 and P < 0.001 compared with unaffected eye and healthy controls, respectively), horizontal cup diameter (P < 0.02 for both), and cup depth (P < 0.02 and P < 0.01, respectively). In the macula, significantly thinner RNFL (nasally), ganglion cell layer (GCL) (nasally and temporally), inner plexiform layer (IPL) (nasally), outer nuclear layer (ONL) (nasally), and inner segment (centrally and temporally) were found in patients with ONH compared with the control group (P < 0.05 for all comparisons). Continuation of significantly thicker GCL, IPL, and outer plexiform layer in the central retinal area (i.e., foveal hypoplasia) was found in more than 80% of patients with ONH. Clinically unaffected fellow eyes of patients with ONH showed mild features of underdevelopment. Visual acuity and presence of septo-optic dysplasia were associated with changes in GCL and IPL. Sensitivity and specificity for the detection of ONH based on disc and retinal optical coherence tomography (OCT) parameters were >80%. Our study provides evidence of retinal changes in ONH. In addition to thinning of retina layers mainly involving the RNFL and GCL, signs reminiscent of foveal hypoplasia were observed in patients with ONH. Optic nerve and foveal parameters measured using OCT showed high sensitivity and specificity for detecting ONH, demonstrating their useful for clinical diagnosis." @default.
• W2037322885 created "2016-06-24" @default.
• W2037322885 creator A5025528727 @default.
• W2037322885 creator A5051474287 @default.
• W2037322885 creator A5054203955 @default.
• W2037322885 creator A5058327385 @default.
• W2037322885 creator A5078996363 @default.
• W2037322885 date "2015-07-01" @default.
• W2037322885 modified "2023-10-16" @default.
• W2037322885 title "High-Resolution Imaging of the Optic Nerve and Retina in Optic Nerve Hypoplasia" @default.
• W2037322885 cites W1513995541 @default.
• W2037322885 cites W1973908083 @default.
• W2037322885 cites W1983539505 @default.
• W2037322885 cites W1984302365 @default.
• W2037322885 cites W1987229904 @default.
• W2037322885 cites W1988482743 @default.
• W2037322885 cites W1989934808 @default.
• W2037322885 cites W1997317215 @default.
• W2037322885 cites W2005113650 @default.
• W2037322885 cites W2009080650 @default.
• W2037322885 cites W2013799954 @default.
• W2037322885 cites W2024200766 @default.
• W2037322885 cites W2027555661 @default.
• W2037322885 cites W2037776984 @default.
• W2037322885 cites W2038080584 @default.
• W2037322885 cites W2039221817 @default.
• W2037322885 cites W2049846787 @default.
• W2037322885 cites W2050836936 @default.
• W2037322885 cites W2051245777 @default.
• W2037322885 cites W2053089578 @default.
• W2037322885 cites W2058586775 @default.
• W2037322885 cites W2065251949 @default.
• W2037322885 cites W2068884033 @default.
• W2037322885 cites W2086002988 @default.
• W2037322885 cites W2086021502 @default.
• W2037322885 cites W2097754957 @default.
• W2037322885 cites W2112540257 @default.
• W2037322885 cites W2117757589 @default.
• W2037322885 cites W2144131272 @default.
• W2037322885 cites W2148129201 @default.
• W2037322885 cites W2155709461 @default.
• W2037322885 cites W2167257392 @default.
• W2037322885 doi "https://doi.org/10.1016/j.ophtha.2015.03.020" @default.
• W2037322885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4518044" @default.
• W2037322885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25939636" @default.
• W2037322885 hasPublicationYear "2015" @default.
• W2037322885 type Work @default.
• W2037322885 sameAs 2037322885 @default.
• W2037322885 citedByCount "61" @default.
• W2037322885 countsByYear W20373228852016 @default.
• W2037322885 countsByYear W20373228852017 @default.
• W2037322885 countsByYear W20373228852018 @default.
• W2037322885 countsByYear W20373228852019 @default.
• W2037322885 countsByYear W20373228852020 @default.
• W2037322885 countsByYear W20373228852021 @default.
• W2037322885 countsByYear W20373228852022 @default.
• W2037322885 countsByYear W20373228852023 @default.
• W2037322885 crossrefType "journal-article" @default.
• W2037322885 hasAuthorship W2037322885A5025528727 @default.
• W2037322885 hasAuthorship W2037322885A5051474287 @default.
• W2037322885 hasAuthorship W2037322885A5054203955 @default.
• W2037322885 hasAuthorship W2037322885A5058327385 @default.
• W2037322885 hasAuthorship W2037322885A5078996363 @default.
• W2037322885 hasBestOaLocation W20373228851 @default.
• W2037322885 hasConcept C105702510 @default.
• W2037322885 hasConcept C118487528 @default.
• W2037322885 hasConcept C120665830 @default.
• W2037322885 hasConcept C121332964 @default.
• W2037322885 hasConcept C2776617768 @default.
• W2037322885 hasConcept C2777093970 @default.
• W2037322885 hasConcept C2777585161 @default.
• W2037322885 hasConcept C2778231335 @default.
• W2037322885 hasConcept C2779735895 @default.
• W2037322885 hasConcept C2780188069 @default.
• W2037322885 hasConcept C2780327212 @default.
• W2037322885 hasConcept C2780592520 @default.
• W2037322885 hasConcept C2780827179 @default.
• W2037322885 hasConcept C2780837183 @default.
• W2037322885 hasConcept C2781334511 @default.
• W2037322885 hasConcept C2983497740 @default.
• W2037322885 hasConcept C71924100 @default.
• W2037322885 hasConceptScore W2037322885C105702510 @default.
• W2037322885 hasConceptScore W2037322885C118487528 @default.
• W2037322885 hasConceptScore W2037322885C120665830 @default.
• W2037322885 hasConceptScore W2037322885C121332964 @default.
• W2037322885 hasConceptScore W2037322885C2776617768 @default.
• W2037322885 hasConceptScore W2037322885C2777093970 @default.
• W2037322885 hasConceptScore W2037322885C2777585161 @default.
• W2037322885 hasConceptScore W2037322885C2778231335 @default.
• W2037322885 hasConceptScore W2037322885C2779735895 @default.
• W2037322885 hasConceptScore W2037322885C2780188069 @default.
• W2037322885 hasConceptScore W2037322885C2780327212 @default.
• W2037322885 hasConceptScore W2037322885C2780592520 @default.
• W2037322885 hasConceptScore W2037322885C2780827179 @default.
• W2037322885 hasConceptScore W2037322885C2780837183 @default.
• W2037322885 hasConceptScore W2037322885C2781334511 @default.
• W2037322885 hasConceptScore W2037322885C2983497740 @default.
• W2037322885 hasConceptScore W2037322885C71924100 @default.

• next