Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037335060> ?p ?o ?g. }
- W2037335060 endingPage "247" @default.
- W2037335060 startingPage "239" @default.
- W2037335060 abstract "The gastrointestinal tract is vital to food digestion and nutrient absorption as well as normal salt and water homeostasis. Studies over the last several years have shown that the Ca2+-sensing receptor is expressed along the entire gastrointestinal tract. The potential roles for the receptor in gastrointestinal biology are now only beginning to be elucidated and much work remains. Well-studied physiological effects include regulation of gastric acid secretion and modulation of fluid transport in the colon. It remains to be determined if the Ca2+-sensing receptor is involved in calcium handling by the gastrointestinal tract. The ability of organic nutrient receptor agonists/allosteric modifiers, such as polyamines and L-amino acids, to activate the Ca2+-sensing receptor suggest potential roles in signalling nutrient availability to gastric and intestinal epithelial cells. In addition, polyamines are crucial for normal cell proliferation and differentiation required to sustain the rapid turnover of gastrointestinal epithelial cells and the Ca2+-sensing receptor may be involved in this function. Activation of the colonic Ca2+-sensing receptor can abrogate cyclic nucleotide-mediated fluid secretion suggesting a role for the receptor in modifying secretory diarrheas like cholera. Finally, the Ca2+-sensing receptor has been suggested to provide a mechanism for the effect of calcium intake in reducing the risk of colon cancer." @default.
- W2037335060 created "2016-06-24" @default.
- W2037335060 creator A5060386684 @default.
- W2037335060 creator A5065040724 @default.
- W2037335060 creator A5074744340 @default.
- W2037335060 date "2004-03-01" @default.
- W2037335060 modified "2023-09-30" @default.
- W2037335060 title "Functions and roles of the extracellular Ca2+-sensing receptor in the gastrointestinal tract" @default.
- W2037335060 cites W144726563 @default.
- W2037335060 cites W1496620474 @default.
- W2037335060 cites W1602958737 @default.
- W2037335060 cites W1821348039 @default.
- W2037335060 cites W1856528466 @default.
- W2037335060 cites W1946033930 @default.
- W2037335060 cites W1960780492 @default.
- W2037335060 cites W1970782960 @default.
- W2037335060 cites W1971935780 @default.
- W2037335060 cites W1982259090 @default.
- W2037335060 cites W1987798906 @default.
- W2037335060 cites W1988631258 @default.
- W2037335060 cites W1994362210 @default.
- W2037335060 cites W1995638940 @default.
- W2037335060 cites W1996036295 @default.
- W2037335060 cites W2000227813 @default.
- W2037335060 cites W2002306854 @default.
- W2037335060 cites W2003197654 @default.
- W2037335060 cites W2003791200 @default.
- W2037335060 cites W2004559818 @default.
- W2037335060 cites W2005620875 @default.
- W2037335060 cites W2008899035 @default.
- W2037335060 cites W2009520291 @default.
- W2037335060 cites W2009766418 @default.
- W2037335060 cites W2017687824 @default.
- W2037335060 cites W2020653282 @default.
- W2037335060 cites W2023661261 @default.
- W2037335060 cites W2024616274 @default.
- W2037335060 cites W2024774687 @default.
- W2037335060 cites W2026258399 @default.
- W2037335060 cites W2027466826 @default.
- W2037335060 cites W2030363901 @default.
- W2037335060 cites W2031705636 @default.
- W2037335060 cites W2034148223 @default.
- W2037335060 cites W2047907147 @default.
- W2037335060 cites W2048796601 @default.
- W2037335060 cites W2049907597 @default.
- W2037335060 cites W2054828183 @default.
- W2037335060 cites W2056986191 @default.
- W2037335060 cites W2058022147 @default.
- W2037335060 cites W2062234837 @default.
- W2037335060 cites W2064231495 @default.
- W2037335060 cites W2065133740 @default.
- W2037335060 cites W2074906319 @default.
- W2037335060 cites W2075929294 @default.
- W2037335060 cites W2094490148 @default.
- W2037335060 cites W2094943858 @default.
- W2037335060 cites W2103871176 @default.
- W2037335060 cites W2106834662 @default.
- W2037335060 cites W2109484905 @default.
- W2037335060 cites W2122047019 @default.
- W2037335060 cites W2122862287 @default.
- W2037335060 cites W2123022315 @default.
- W2037335060 cites W2123465981 @default.
- W2037335060 cites W2125297586 @default.
- W2037335060 cites W2128686820 @default.
- W2037335060 cites W2132646585 @default.
- W2037335060 cites W2132833183 @default.
- W2037335060 cites W2138733161 @default.
- W2037335060 cites W2142292929 @default.
- W2037335060 cites W2142779171 @default.
- W2037335060 cites W2144603992 @default.
- W2037335060 cites W2159539566 @default.
- W2037335060 cites W2164451296 @default.
- W2037335060 cites W2171807112 @default.
- W2037335060 cites W2183475472 @default.
- W2037335060 cites W2273016318 @default.
- W2037335060 cites W2281124822 @default.
- W2037335060 cites W2319963574 @default.
- W2037335060 cites W2467824185 @default.
- W2037335060 cites W275394003 @default.
- W2037335060 cites W2940365551 @default.
- W2037335060 cites W4232279861 @default.
- W2037335060 cites W4244452570 @default.
- W2037335060 cites W4252620922 @default.
- W2037335060 cites W2137355756 @default.
- W2037335060 doi "https://doi.org/10.1016/j.ceca.2003.10.015" @default.
- W2037335060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15200147" @default.
- W2037335060 hasPublicationYear "2004" @default.
- W2037335060 type Work @default.
- W2037335060 sameAs 2037335060 @default.
- W2037335060 citedByCount "109" @default.
- W2037335060 countsByYear W20373350602012 @default.
- W2037335060 countsByYear W20373350602013 @default.
- W2037335060 countsByYear W20373350602014 @default.
- W2037335060 countsByYear W20373350602015 @default.
- W2037335060 countsByYear W20373350602016 @default.
- W2037335060 countsByYear W20373350602017 @default.
- W2037335060 countsByYear W20373350602018 @default.
- W2037335060 countsByYear W20373350602019 @default.