FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037335928> ?p ?o ?g. }

• W2037335928 endingPage "2165" @default.
• W2037335928 startingPage "2159" @default.
• W2037335928 abstract "Muscle invasive bladder cancer is an aggressive type of epithelial tumor with a high rate of metastasis. For bladder cancer cells to reach the muscle layer, cells must invade through an urothelial cell monolayer (transurothelial invasion) and basement membrane. However, the process by which transurothelial invasion occurs has not been fully characterized. In this study we developed a novel method to evaluate the transurothelial invasion capacity and investigated its cellular and molecular processes using primary culture cells from bladder cancer patients. The analysis revealed that compared with the prognosis for patients with non‑muscle invasive bladder cancer that of patients with muscle invasive bladder cancer was particularly poor due to metastatic recurrence. Cancer cells from patients with muscle invasive bladder cancer exhibited a higher invasive capacity through the urothelial cell monolayer compared with those from non‑invasive bladder cancer patients. Furthermore, muscle invasive bladder cancer cells demonstrated a greater ability to form invadopodia, the filamentous actin‑based membrane protrusions required for matrix degradation and invasion compared with non‑invasive cells. Bladder cancer cell lines were established with reduced invadopodia formation by silencing the expression of cortactin, an essential component of invadopodia. The cortactin knockdown bladder cancer cells with reduced invadopodia formation demonstrated a markedly reduced ability to invade through the urothelial cell monolayer, indicating that invadopodia are essential for transurothelial invasion. The results indicate that invadopodia formation is required for muscle invasion of aggressive bladder cancer cells." @default.
• W2037335928 created "2016-06-24" @default.
• W2037335928 creator A5000917334 @default.
• W2037335928 creator A5003258424 @default.
• W2037335928 creator A5013782799 @default.
• W2037335928 creator A5026803124 @default.
• W2037335928 creator A5027783496 @default.
• W2037335928 creator A5032629558 @default.
• W2037335928 creator A5033101192 @default.
• W2037335928 creator A5052055898 @default.
• W2037335928 creator A5055415323 @default.
• W2037335928 creator A5070594137 @default.
• W2037335928 creator A5076273759 @default.
• W2037335928 date "2014-04-03" @default.
• W2037335928 modified "2023-09-30" @default.
• W2037335928 title "Invadopodia are essential in transurothelial invasion during the muscle invasion of bladder cancer cells" @default.
• W2037335928 cites W175000267 @default.
• W2037335928 cites W1988787904 @default.
• W2037335928 cites W2022233074 @default.
• W2037335928 cites W2023506783 @default.
• W2037335928 cites W2025636263 @default.
• W2037335928 cites W2101946022 @default.
• W2037335928 cites W2112229259 @default.
• W2037335928 cites W2125743967 @default.
• W2037335928 cites W2136270276 @default.
• W2037335928 cites W2143593234 @default.
• W2037335928 cites W2312666913 @default.
• W2037335928 cites W2888986801 @default.
• W2037335928 doi "https://doi.org/10.3892/mmr.2014.2113" @default.
• W2037335928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24699942" @default.
• W2037335928 hasPublicationYear "2014" @default.
• W2037335928 type Work @default.
• W2037335928 sameAs 2037335928 @default.
• W2037335928 citedByCount "7" @default.
• W2037335928 countsByYear W20373359282016 @default.
• W2037335928 countsByYear W20373359282017 @default.
• W2037335928 countsByYear W20373359282019 @default.
• W2037335928 countsByYear W20373359282021 @default.
• W2037335928 countsByYear W20373359282022 @default.
• W2037335928 countsByYear W20373359282023 @default.
• W2037335928 crossrefType "journal-article" @default.
• W2037335928 hasAuthorship W2037335928A5000917334 @default.
• W2037335928 hasAuthorship W2037335928A5003258424 @default.
• W2037335928 hasAuthorship W2037335928A5013782799 @default.
• W2037335928 hasAuthorship W2037335928A5026803124 @default.
• W2037335928 hasAuthorship W2037335928A5027783496 @default.
• W2037335928 hasAuthorship W2037335928A5032629558 @default.
• W2037335928 hasAuthorship W2037335928A5033101192 @default.
• W2037335928 hasAuthorship W2037335928A5052055898 @default.
• W2037335928 hasAuthorship W2037335928A5055415323 @default.
• W2037335928 hasAuthorship W2037335928A5070594137 @default.
• W2037335928 hasAuthorship W2037335928A5076273759 @default.
• W2037335928 hasBestOaLocation W20373359281 @default.
• W2037335928 hasConcept C121608353 @default.
• W2037335928 hasConcept C126322002 @default.
• W2037335928 hasConcept C142669718 @default.
• W2037335928 hasConcept C142724271 @default.
• W2037335928 hasConcept C1491633281 @default.
• W2037335928 hasConcept C200786668 @default.
• W2037335928 hasConcept C2776000893 @default.
• W2037335928 hasConcept C2777540882 @default.
• W2037335928 hasConcept C2779013556 @default.
• W2037335928 hasConcept C2779762690 @default.
• W2037335928 hasConcept C2780352672 @default.
• W2037335928 hasConcept C2910041100 @default.
• W2037335928 hasConcept C502942594 @default.
• W2037335928 hasConcept C54355233 @default.
• W2037335928 hasConcept C71924100 @default.
• W2037335928 hasConcept C86803240 @default.
• W2037335928 hasConcept C96232424 @default.
• W2037335928 hasConceptScore W2037335928C121608353 @default.
• W2037335928 hasConceptScore W2037335928C126322002 @default.
• W2037335928 hasConceptScore W2037335928C142669718 @default.
• W2037335928 hasConceptScore W2037335928C142724271 @default.
• W2037335928 hasConceptScore W2037335928C1491633281 @default.
• W2037335928 hasConceptScore W2037335928C200786668 @default.
• W2037335928 hasConceptScore W2037335928C2776000893 @default.
• W2037335928 hasConceptScore W2037335928C2777540882 @default.
• W2037335928 hasConceptScore W2037335928C2779013556 @default.
• W2037335928 hasConceptScore W2037335928C2779762690 @default.
• W2037335928 hasConceptScore W2037335928C2780352672 @default.
• W2037335928 hasConceptScore W2037335928C2910041100 @default.
• W2037335928 hasConceptScore W2037335928C502942594 @default.
• W2037335928 hasConceptScore W2037335928C54355233 @default.
• W2037335928 hasConceptScore W2037335928C71924100 @default.
• W2037335928 hasConceptScore W2037335928C86803240 @default.
• W2037335928 hasConceptScore W2037335928C96232424 @default.
• W2037335928 hasIssue "6" @default.
• W2037335928 hasLocation W20373359281 @default.
• W2037335928 hasLocation W20373359282 @default.
• W2037335928 hasLocation W20373359283 @default.
• W2037335928 hasOpenAccess W2037335928 @default.
• W2037335928 hasPrimaryLocation W20373359281 @default.
• W2037335928 hasRelatedWork W2037335928 @default.
• W2037335928 hasRelatedWork W2052081346 @default.
• W2037335928 hasRelatedWork W2154708791 @default.
• W2037335928 hasRelatedWork W2326758311 @default.
• W2037335928 hasRelatedWork W2378845874 @default.

• next