FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037335929> ?p ?o ?g. }

• W2037335929 endingPage "38" @default.
• W2037335929 startingPage "33" @default.
• W2037335929 abstract "This study investigated the progression of multidrug resistance upon exposure to imipenem in Acinetobacter baumannii. Eighteen A. baumannii strains, including two reference strains (ATCC 19606 and ATCC 17978), four clinical strains (AB56, AB242, AB273 and AB279) and 12 antibiotic-selected mutant strains, were used in this study. Imipenem-selected mutants were generated from imipenem-susceptible strains (ATCC 19606, ATCC 17978 and AB242) by multistep selection resistance. Amikacin-, ciprofloxacin-, colistin-, meropenem- and ceftazidime-selected mutants were also generated from the two reference strains and were used for comparison. Antibiotic susceptibilities in the absence and presence of the efflux pump inhibitors carbonyl cyanide m-chlorophenylhydrazone (CCCP) and 1-(1-naphthylmethyl)-piperazine (NMP) were examined in the three imipenem-selected mutants and the three clinical multidrug-resistant (MDR) isolates. Expression profiles of the antimicrobial resistance genes in the imipenem-selected mutants and their parental strains were also determined. The results showed that imipenem was more likely, compared with the other antibiotics, to induce a MDR phenotype in the two reference strains. Differences in OXA-51-like carbapenemase, efflux pumps or/and AmpC β-lactamase expression were observed in the three imipenem-selected mutants. Moreover, a reduction in imipenem or amikacin resistance was observed when the imipenem-selected mutants and clinical isolates were exposed to NMP and CCCP. This study concluded that imipenem might be a potent inducer of multidrug resistance in A. baumannii strains. OXA-51-like carbapenemase combined with other resistance mechanisms may contribute to the development of multidrug resistance in A. baumannii. Monitoring the use of carbapenems is required to reduce the spread of MDR A. baumannii in hospitals." @default.
• W2037335929 created "2016-06-24" @default.
• W2037335929 creator A5040186664 @default.
• W2037335929 creator A5055571882 @default.
• W2037335929 creator A5069796797 @default.
• W2037335929 creator A5076955750 @default.
• W2037335929 creator A5084845722 @default.
• W2037335929 date "2012-01-01" @default.
• W2037335929 modified "2023-09-23" @default.
• W2037335929 title "Imipenem: a potent inducer of multidrug resistance in Acinetobacter baumannii" @default.
• W2037335929 cites W1967904223 @default.
• W2037335929 cites W1971252925 @default.
• W2037335929 cites W1973792835 @default.
• W2037335929 cites W1977806172 @default.
• W2037335929 cites W1996664300 @default.
• W2037335929 cites W1997495012 @default.
• W2037335929 cites W2002210327 @default.
• W2037335929 cites W2017115870 @default.
• W2037335929 cites W2037248614 @default.
• W2037335929 cites W2055315617 @default.
• W2037335929 cites W2058989421 @default.
• W2037335929 cites W2071416115 @default.
• W2037335929 cites W2083037469 @default.
• W2037335929 cites W2093115743 @default.
• W2037335929 cites W2096905968 @default.
• W2037335929 cites W2109086196 @default.
• W2037335929 cites W2110991941 @default.
• W2037335929 cites W2112882791 @default.
• W2037335929 cites W2116542556 @default.
• W2037335929 cites W2116554892 @default.
• W2037335929 cites W2116661024 @default.
• W2037335929 cites W2118328361 @default.
• W2037335929 cites W2118528768 @default.
• W2037335929 cites W2118665746 @default.
• W2037335929 cites W2134442153 @default.
• W2037335929 cites W2135113667 @default.
• W2037335929 cites W2137799330 @default.
• W2037335929 cites W2144038123 @default.
• W2037335929 cites W2144261829 @default.
• W2037335929 cites W2167131009 @default.
• W2037335929 cites W2167385770 @default.
• W2037335929 cites W2169499475 @default.
• W2037335929 doi "https://doi.org/10.1016/j.ijantimicag.2011.08.016" @default.
• W2037335929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21996406" @default.
• W2037335929 hasPublicationYear "2012" @default.
• W2037335929 type Work @default.
• W2037335929 sameAs 2037335929 @default.
• W2037335929 citedByCount "44" @default.
• W2037335929 countsByYear W20373359292012 @default.
• W2037335929 countsByYear W20373359292013 @default.
• W2037335929 countsByYear W20373359292014 @default.
• W2037335929 countsByYear W20373359292015 @default.
• W2037335929 countsByYear W20373359292016 @default.
• W2037335929 countsByYear W20373359292017 @default.
• W2037335929 countsByYear W20373359292018 @default.
• W2037335929 countsByYear W20373359292019 @default.
• W2037335929 countsByYear W20373359292020 @default.
• W2037335929 countsByYear W20373359292021 @default.
• W2037335929 crossrefType "journal-article" @default.
• W2037335929 hasAuthorship W2037335929A5040186664 @default.
• W2037335929 hasAuthorship W2037335929A5055571882 @default.
• W2037335929 hasAuthorship W2037335929A5069796797 @default.
• W2037335929 hasAuthorship W2037335929A5076955750 @default.
• W2037335929 hasAuthorship W2037335929A5084845722 @default.
• W2037335929 hasBestOaLocation W20373359292 @default.
• W2037335929 hasConcept C114851261 @default.
• W2037335929 hasConcept C133936738 @default.
• W2037335929 hasConcept C200082930 @default.
• W2037335929 hasConcept C2776315533 @default.
• W2037335929 hasConcept C2776685102 @default.
• W2037335929 hasConcept C2777427914 @default.
• W2037335929 hasConcept C2777637488 @default.
• W2037335929 hasConcept C2779259085 @default.
• W2037335929 hasConcept C2779375183 @default.
• W2037335929 hasConcept C2779631663 @default.
• W2037335929 hasConcept C501593827 @default.
• W2037335929 hasConcept C523546767 @default.
• W2037335929 hasConcept C54355233 @default.
• W2037335929 hasConcept C86803240 @default.
• W2037335929 hasConcept C89423630 @default.
• W2037335929 hasConcept C94665300 @default.
• W2037335929 hasConceptScore W2037335929C114851261 @default.
• W2037335929 hasConceptScore W2037335929C133936738 @default.
• W2037335929 hasConceptScore W2037335929C200082930 @default.
• W2037335929 hasConceptScore W2037335929C2776315533 @default.
• W2037335929 hasConceptScore W2037335929C2776685102 @default.
• W2037335929 hasConceptScore W2037335929C2777427914 @default.
• W2037335929 hasConceptScore W2037335929C2777637488 @default.
• W2037335929 hasConceptScore W2037335929C2779259085 @default.
• W2037335929 hasConceptScore W2037335929C2779375183 @default.
• W2037335929 hasConceptScore W2037335929C2779631663 @default.
• W2037335929 hasConceptScore W2037335929C501593827 @default.
• W2037335929 hasConceptScore W2037335929C523546767 @default.
• W2037335929 hasConceptScore W2037335929C54355233 @default.
• W2037335929 hasConceptScore W2037335929C86803240 @default.
• W2037335929 hasConceptScore W2037335929C89423630 @default.
• W2037335929 hasConceptScore W2037335929C94665300 @default.
• W2037335929 hasIssue "1" @default.

• next