FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037337675> ?p ?o ?g. }

• W2037337675 endingPage "216" @default.
• W2037337675 startingPage "205" @default.
• W2037337675 abstract "Cocaine withdrawal symptoms are thought to play a role in relapse; studies characterizing the symptomatology have yielded mixed findings. This study sought to examine the pharmacodynamic/pharmacokinetic profile of repeated high dose exposure to oral cocaine and characterize acute and protracted withdrawal in cocaine abusers. This study employed a repeated-dosing, single-blind design in which subjects (n = 9), resided for 40 days on a closed ward. They were maintained for two 4-day cocaine exposure periods (Days 1-4 & Days 9-12, cocaine 175 mg, p.o.; 5 hourly doses; 875 mg/day) separated by a 4-day matched placebo exposure period (Days 5-8). After these 12 days, an additional period of 28 days of placebo maintenance followed (Days 13-40). Test sessions were conducted during each phase; measures of mood, drug effects, sleep, pharmacokinetics, and prolactin were collected throughout the study. The dosing regimen produced cocaine plasma concentrations (Cmax of 680 ng/mL) two to threefold higher than typically seen in acute dose studies. Prototypic psychostimulant effects, including subjective ratings of euphoric effects (liking, high, good effects) and significant cardiopressor effects, were sustained during the active dosing periods, corresponding to the rise and fall of plasma cocaine. Withdrawal-like symptoms (i.e., disruptions of sleep, increased ratings of anxiety, irritability, crashing) were observed within 24-hr after cessation of dosing. Cocaine reduced prolactin acutely, but no sustained alterations were observed for this measure or for other signs or symptoms during the 28-day abstinence period. These findings indicate that exposure to controlled high doses of cocaine produces modest symptoms consistent with cocaine withdrawal within hours of cessation of dosing but provide no evidence of symptoms persisting beyond 24 hours." @default.
• W2037337675 created "2016-06-24" @default.
• W2037337675 creator A5021278551 @default.
• W2037337675 creator A5031442075 @default.
• W2037337675 creator A5059086864 @default.
• W2037337675 creator A5071583939 @default.
• W2037337675 creator A5072239291 @default.
• W2037337675 date "2009-01-01" @default.
• W2037337675 modified "2023-09-26" @default.
• W2037337675 title "Repeated dosing with oral cocaine in humans: Assessment of direct effects, withdrawal, and pharmacokinetics." @default.
• W2037337675 cites W1496028880 @default.
• W2037337675 cites W1607171655 @default.
• W2037337675 cites W1827410234 @default.
• W2037337675 cites W1902369285 @default.
• W2037337675 cites W1932666659 @default.
• W2037337675 cites W1963512293 @default.
• W2037337675 cites W1967443225 @default.
• W2037337675 cites W1971608985 @default.
• W2037337675 cites W1976870178 @default.
• W2037337675 cites W1978886969 @default.
• W2037337675 cites W1980446583 @default.
• W2037337675 cites W1996809124 @default.
• W2037337675 cites W2003339737 @default.
• W2037337675 cites W2008032124 @default.
• W2037337675 cites W2011151720 @default.
• W2037337675 cites W2013568408 @default.
• W2037337675 cites W2017472836 @default.
• W2037337675 cites W2019419394 @default.
• W2037337675 cites W2023564789 @default.
• W2037337675 cites W2032214444 @default.
• W2037337675 cites W2039355437 @default.
• W2037337675 cites W2041070835 @default.
• W2037337675 cites W2043507098 @default.
• W2037337675 cites W2045647912 @default.
• W2037337675 cites W2047173405 @default.
• W2037337675 cites W2048508569 @default.
• W2037337675 cites W2052190817 @default.
• W2037337675 cites W2061549293 @default.
• W2037337675 cites W2067495470 @default.
• W2037337675 cites W2067979207 @default.
• W2037337675 cites W2069943414 @default.
• W2037337675 cites W2074494634 @default.
• W2037337675 cites W2084071932 @default.
• W2037337675 cites W2088689591 @default.
• W2037337675 cites W2099360173 @default.
• W2037337675 cites W2111267491 @default.
• W2037337675 cites W2118252740 @default.
• W2037337675 cites W2125037719 @default.
• W2037337675 cites W2126097810 @default.
• W2037337675 cites W2151939573 @default.
• W2037337675 cites W2163477073 @default.
• W2037337675 cites W2166035496 @default.
• W2037337675 cites W2197594429 @default.
• W2037337675 cites W2262396283 @default.
• W2037337675 cites W2346959755 @default.
• W2037337675 cites W2735928575 @default.
• W2037337675 cites W472258453 @default.
• W2037337675 cites W54728729 @default.
• W2037337675 doi "https://doi.org/10.1037/a0016469" @default.
• W2037337675 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2811070" @default.
• W2037337675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19653786" @default.
• W2037337675 hasPublicationYear "2009" @default.
• W2037337675 type Work @default.
• W2037337675 sameAs 2037337675 @default.
• W2037337675 citedByCount "44" @default.
• W2037337675 countsByYear W20373376752012 @default.
• W2037337675 countsByYear W20373376752013 @default.
• W2037337675 countsByYear W20373376752014 @default.
• W2037337675 countsByYear W20373376752015 @default.
• W2037337675 countsByYear W20373376752017 @default.
• W2037337675 countsByYear W20373376752018 @default.
• W2037337675 countsByYear W20373376752019 @default.
• W2037337675 countsByYear W20373376752020 @default.
• W2037337675 countsByYear W20373376752021 @default.
• W2037337675 countsByYear W20373376752022 @default.
• W2037337675 crossrefType "journal-article" @default.
• W2037337675 hasAuthorship W2037337675A5021278551 @default.
• W2037337675 hasAuthorship W2037337675A5031442075 @default.
• W2037337675 hasAuthorship W2037337675A5059086864 @default.
• W2037337675 hasAuthorship W2037337675A5071583939 @default.
• W2037337675 hasAuthorship W2037337675A5072239291 @default.
• W2037337675 hasBestOaLocation W20373376752 @default.
• W2037337675 hasConcept C102959455 @default.
• W2037337675 hasConcept C105795698 @default.
• W2037337675 hasConcept C111113717 @default.
• W2037337675 hasConcept C112705442 @default.
• W2037337675 hasConcept C118552586 @default.
• W2037337675 hasConcept C142724271 @default.
• W2037337675 hasConcept C204787440 @default.
• W2037337675 hasConcept C22979827 @default.
• W2037337675 hasConcept C27081682 @default.
• W2037337675 hasConcept C2777288759 @default.
• W2037337675 hasConcept C2778062832 @default.
• W2037337675 hasConcept C2779796075 @default.
• W2037337675 hasConcept C2780035454 @default.
• W2037337675 hasConcept C2780687700 @default.
• W2037337675 hasConcept C2780820931 @default.
• W2037337675 hasConcept C33923547 @default.

• next