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• W2037356296 abstract "Aims: To assess the impact of cytokeratin (CK) 5/6 and E‐cadherin immunohistochemistry on diagnostic agreement of non‐invasive proliferative breast lesions. Methods and results: Twenty pathologists classified 105 cases of non‐invasive proliferative breast lesions into 10 diagnostic categories. One haematoxylin and eosin (H&E) slide of each case was analysed on a first round and one H&E slide with corresponding CK5/6 and E‐cadherin immunohistochemistry was analysed on a second round. Interobserver reproducibility for category‐specific and management‐specific lesions was measured on each round. CK5/6 and E‐cadherin had little impact on diagnostic agreement, which remained moderate between the first and second rounds (overall κ coefficients of 0.47 and 0.53, respectively, P = NS). Levels of agreement slightly improved for lesions with specific CK5/6 and E‐cadherin immunoprofiles (usual ductal hyperplasia, atypical ductal hyperplasia, atypical lobular hyperplasia, lobular carcinoma in situ , non‐high‐grade ductal carcinoma in situ ), but the differences observed were not statistically significant. However, diagnostic agreement improved when lesions were grouped according to their management category (overall κ coefficients of 0.58 and 0.66 in the first and second rounds, respectively). Conclusions: CK5/6 and E‐cadherin immunohistochemistry has little impact on interobserver reproducibility for non‐invasive breast lesions. Diagnostic agreement can, however, be improved by grouping lesions in management categories." @default.
• W2037356296 created "2016-06-24" @default.
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• W2037356296 date "2008-04-07" @default.
• W2037356296 modified "2023-10-18" @default.
• W2037356296 title "Impact of immunohistochemical markers, CK5/6 and E-cadherin on diagnostic agreement in non-invasive proliferative breast lesions" @default.
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• W2037356296 doi "https://doi.org/10.1111/j.1365-2559.2008.03016.x" @default.
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