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• W2037357430 endingPage "137" @default.
• W2037357430 startingPage "131" @default.
• W2037357430 abstract "Teniposide (TEN) is a potent, broad spectrum antitumor agent, especially for cerebroma. But the application in clinic was limited because of its poor solubility. In this paper, teniposide nanosuspensions drug delivery system (TEN-NSDDS) for intravenous administration was developed for the first time. Specifically, TEN nanosuspensions were prepared by an anti-solvent sonication-precipitation method and evaluated in comparison with teniposide injection (VUMON) in vitro and in vivo. TEN nanosuspensions prepared showed rod-like morphology and the size was 151 ± 11 nm with a narrow poly dispersion index 0.138 determined by dynamic light scattering. The obtained TEN nanosuspensions were physically stable at least 10 days at 4°C. And the freeze-drying preparations were stable during 3 months. The cytotoxicity of TEN nanosuspensions were considerable to that of VUMON against U87MG and C6 cells in vitro. When tested in rats bearing C6 tumors, the TEN concentration in the tumors treated by the nanosuspensions was more than 20 times than that by the TEN solution at 2h. The TEN nanosuspensions exhibited significant tumor growth inhibition. Overall, the results suggested that nanosuspensions was an alternative formulation for teniposide to be administered intravenously, and it would be a promising formulation in clinic." @default.
• W2037357430 created "2016-06-24" @default.
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• W2037357430 date "2015-01-01" @default.
• W2037357430 modified "2023-09-27" @default.
• W2037357430 title "Preparation and in vitro – in vivo evaluation of teniposide nanosuspensions" @default.
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• W2037357430 doi "https://doi.org/10.1016/j.ijpharm.2014.11.020" @default.
• W2037357430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25448575" @default.
• W2037357430 hasPublicationYear "2015" @default.
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