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- W2037364812 abstract "The forebrain is the brain region which has undergone the most dramatic changes through vertebrate evolution. Analyses conducted in lampreys are essential to gain insight into the broad ancestral characteristics of the forebrain at the dawn of vertebrates, and to understand the molecular basis for the diversifications that have taken place in cyclostomes and gnathostomes following their splitting. Here, we report the embryonic expression patterns of 43 lamprey genes, coding for transcription factors or signaling molecules known to be involved in cell proliferation, stemcellness, neurogenesis, patterning and regionalization in the developing forebrain. Systematic expression patterns comparisons with model organisms highlight conservations likely to reflect shared features present in the vertebrate ancestors. They also point to changes in signaling systems -pathways which control the growth and patterning of the neuroepithelium-, which may have been crucial in the evolution of forebrain anatomy at the origin of vertebrates." @default.
- W2037364812 created "2016-06-24" @default.
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- W2037364812 date "2009-04-28" @default.
- W2037364812 modified "2023-10-17" @default.
- W2037364812 title "Neurodevelopment Genes in Lampreys Reveal Trends for Forebrain Evolution in Craniates" @default.
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- W2037364812 doi "https://doi.org/10.1371/journal.pone.0005374" @default.
- W2037364812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2671401" @default.
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