Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037365513> ?p ?o ?g. }
- W2037365513 endingPage "496" @default.
- W2037365513 startingPage "489" @default.
- W2037365513 abstract "The bacterial signaling molecule cyclic di-GMP (c-di-GMP) stimulates the synthesis of bacterial cellulose, which is frequently found in biofilms. Bacterial cellulose is synthesized and translocated across the inner membrane by a complex of cellulose synthase BcsA and BcsB subunits. Here we present crystal structures of the c-di-GMP-activated BcsA-BcsB complex. The structures reveal that c-di-GMP releases an autoinhibited state of the enzyme by breaking a salt bridge that otherwise tethers a conserved gating loop that controls access to and substrate coordination at the active site. Disrupting the salt bridge by mutagenesis generates a constitutively active cellulose synthase. Additionally, the c-di-GMP-activated BcsA-BcsB complex contains a nascent cellulose polymer whose terminal glucose unit rests at a new location above BcsA's active site and is positioned for catalysis. Our mechanistic insights indicate how c-di-GMP allosterically modulates enzymatic functions." @default.
- W2037365513 created "2016-06-24" @default.
- W2037365513 creator A5003187923 @default.
- W2037365513 creator A5031577912 @default.
- W2037365513 creator A5078603869 @default.
- W2037365513 date "2014-04-06" @default.
- W2037365513 modified "2023-10-16" @default.
- W2037365513 title "Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP" @default.
- W2037365513 cites W134674384 @default.
- W2037365513 cites W1571601425 @default.
- W2037365513 cites W1730782230 @default.
- W2037365513 cites W1912762964 @default.
- W2037365513 cites W1964995917 @default.
- W2037365513 cites W1966701251 @default.
- W2037365513 cites W1966857950 @default.
- W2037365513 cites W1971634629 @default.
- W2037365513 cites W1973456850 @default.
- W2037365513 cites W1976511855 @default.
- W2037365513 cites W1976778204 @default.
- W2037365513 cites W1989942811 @default.
- W2037365513 cites W1990403693 @default.
- W2037365513 cites W1990483043 @default.
- W2037365513 cites W1990652169 @default.
- W2037365513 cites W1991102091 @default.
- W2037365513 cites W2001641653 @default.
- W2037365513 cites W2007432423 @default.
- W2037365513 cites W2016965453 @default.
- W2037365513 cites W2020465369 @default.
- W2037365513 cites W2022435931 @default.
- W2037365513 cites W2032209119 @default.
- W2037365513 cites W2036195365 @default.
- W2037365513 cites W2042210230 @default.
- W2037365513 cites W2043082285 @default.
- W2037365513 cites W2049519918 @default.
- W2037365513 cites W2052105084 @default.
- W2037365513 cites W2052908852 @default.
- W2037365513 cites W2055261049 @default.
- W2037365513 cites W2059029715 @default.
- W2037365513 cites W2061448692 @default.
- W2037365513 cites W2067921100 @default.
- W2037365513 cites W2080119168 @default.
- W2037365513 cites W2087017025 @default.
- W2037365513 cites W2088890614 @default.
- W2037365513 cites W2090556419 @default.
- W2037365513 cites W2095997872 @default.
- W2037365513 cites W2108804414 @default.
- W2037365513 cites W2108929776 @default.
- W2037365513 cites W2108959691 @default.
- W2037365513 cites W2109310563 @default.
- W2037365513 cites W2110893691 @default.
- W2037365513 cites W2111482169 @default.
- W2037365513 cites W2112289062 @default.
- W2037365513 cites W2112921913 @default.
- W2037365513 cites W2113904137 @default.
- W2037365513 cites W2119610782 @default.
- W2037365513 cites W2120019026 @default.
- W2037365513 cites W2123323202 @default.
- W2037365513 cites W2125603952 @default.
- W2037365513 cites W2130257593 @default.
- W2037365513 cites W2131777290 @default.
- W2037365513 cites W2132665880 @default.
- W2037365513 cites W2141421676 @default.
- W2037365513 cites W2141456567 @default.
- W2037365513 cites W2144081223 @default.
- W2037365513 cites W2145792008 @default.
- W2037365513 cites W2146080841 @default.
- W2037365513 cites W2151318932 @default.
- W2037365513 cites W2163341755 @default.
- W2037365513 cites W2172180816 @default.
- W2037365513 cites W2180229411 @default.
- W2037365513 doi "https://doi.org/10.1038/nsmb.2803" @default.
- W2037365513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4013215" @default.
- W2037365513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24704788" @default.
- W2037365513 hasPublicationYear "2014" @default.
- W2037365513 type Work @default.
- W2037365513 sameAs 2037365513 @default.
- W2037365513 citedByCount "267" @default.
- W2037365513 countsByYear W20373655132014 @default.
- W2037365513 countsByYear W20373655132015 @default.
- W2037365513 countsByYear W20373655132016 @default.
- W2037365513 countsByYear W20373655132017 @default.
- W2037365513 countsByYear W20373655132018 @default.
- W2037365513 countsByYear W20373655132019 @default.
- W2037365513 countsByYear W20373655132020 @default.
- W2037365513 countsByYear W20373655132021 @default.
- W2037365513 countsByYear W20373655132022 @default.
- W2037365513 countsByYear W20373655132023 @default.
- W2037365513 crossrefType "journal-article" @default.
- W2037365513 hasAuthorship W2037365513A5003187923 @default.
- W2037365513 hasAuthorship W2037365513A5031577912 @default.
- W2037365513 hasAuthorship W2037365513A5078603869 @default.
- W2037365513 hasBestOaLocation W20373655132 @default.
- W2037365513 hasConcept C104317684 @default.
- W2037365513 hasConcept C112243037 @default.
- W2037365513 hasConcept C12554922 @default.
- W2037365513 hasConcept C143065580 @default.
- W2037365513 hasConcept C181199279 @default.
- W2037365513 hasConcept C185592680 @default.