FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037368532> ?p ?o ?g. }

• W2037368532 endingPage "347" @default.
• W2037368532 startingPage "341" @default.
• W2037368532 abstract "Abstract To investigate the effects of altered collagen II (CII) peptide ligands in collagen‐induced arthritis (CIA), CIA rats were subcutaneously injected with an altered CII263–272 peptide ligand (APL, 100, 10, and 1 μg/dose, six dose each, twice a week), which had been identified by us as an inhibitory effect on CII‐specific T‐cell activation in vitro in rheumatoid arthritis (RA). Clinical, radiographic, and histologic scores were evaluated. Serum level of interferon (IFN)‐γ was assessed by enzyme‐linked immunosorbent assay, and the numbers of interleukin (IL)‐4‐producing cells in vitro in memory responses to the APL were determined by enzyme‐linked immunospot. The results showed significantly reduced arthritis scores in CIA rats treated with 100 μg/dose of APL compared with those treated with phosphate buffered solution (PBS) and control peptide. The mean radiographic and histologic scores were also markedly lower in APL‐treated CIA rats. On day 35 after immunization, a significantly lower level of IFN‐γ in serum was found in APL‐treated rats, accompanied by increased numbers of IL‐4‐producing cells, indicating that APL treatment skewed the T helper (Th)1/Th2 balance toward Th2‐type response in vivo . Altered CII263–272 peptide ligand immunization induces inhibition of CIA through a shift toward Th2‐type response, suggesting that altered CII peptide might be a potential therapeutic target for RA." @default.
• W2037368532 created "2016-06-24" @default.
• W2037368532 creator A5035927897 @default.
• W2037368532 creator A5057521694 @default.
• W2037368532 creator A5071390383 @default.
• W2037368532 date "2009-03-13" @default.
• W2037368532 modified "2023-10-12" @default.
• W2037368532 title "Altered collagen II 263-272 peptide immunization induces inhibition of collagen-induced arthritis through a shift toward Th2-type response" @default.
• W2037368532 cites W1521812283 @default.
• W2037368532 cites W1552817512 @default.
• W2037368532 cites W1568910239 @default.
• W2037368532 cites W1955836577 @default.
• W2037368532 cites W1968868444 @default.
• W2037368532 cites W1983111895 @default.
• W2037368532 cites W1996371542 @default.
• W2037368532 cites W1997430037 @default.
• W2037368532 cites W1998274752 @default.
• W2037368532 cites W2001225313 @default.
• W2037368532 cites W2008686589 @default.
• W2037368532 cites W2027700425 @default.
• W2037368532 cites W2036943040 @default.
• W2037368532 cites W2037809865 @default.
• W2037368532 cites W2038422739 @default.
• W2037368532 cites W2049706385 @default.
• W2037368532 cites W2055539033 @default.
• W2037368532 cites W2057882856 @default.
• W2037368532 cites W2070016857 @default.
• W2037368532 cites W2072080335 @default.
• W2037368532 cites W2082323926 @default.
• W2037368532 cites W2090372222 @default.
• W2037368532 cites W2094026324 @default.
• W2037368532 cites W2095253463 @default.
• W2037368532 cites W2097376175 @default.
• W2037368532 cites W2110724503 @default.
• W2037368532 cites W2144582765 @default.
• W2037368532 cites W2149216983 @default.
• W2037368532 cites W2162434730 @default.
• W2037368532 cites W2166510335 @default.
• W2037368532 cites W2305857834 @default.
• W2037368532 cites W4236183098 @default.
• W2037368532 cites W4367011195 @default.
• W2037368532 doi "https://doi.org/10.1111/j.1399-0039.2009.01223.x" @default.
• W2037368532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19317744" @default.
• W2037368532 hasPublicationYear "2009" @default.
• W2037368532 type Work @default.
• W2037368532 sameAs 2037368532 @default.
• W2037368532 citedByCount "12" @default.
• W2037368532 countsByYear W20373685322012 @default.
• W2037368532 countsByYear W20373685322015 @default.
• W2037368532 countsByYear W20373685322016 @default.
• W2037368532 countsByYear W20373685322017 @default.
• W2037368532 countsByYear W20373685322023 @default.
• W2037368532 crossrefType "journal-article" @default.
• W2037368532 hasAuthorship W2037368532A5035927897 @default.
• W2037368532 hasAuthorship W2037368532A5057521694 @default.
• W2037368532 hasAuthorship W2037368532A5071390383 @default.
• W2037368532 hasConcept C126322002 @default.
• W2037368532 hasConcept C134018914 @default.
• W2037368532 hasConcept C150903083 @default.
• W2037368532 hasConcept C185592680 @default.
• W2037368532 hasConcept C202751555 @default.
• W2037368532 hasConcept C203014093 @default.
• W2037368532 hasConcept C207001950 @default.
• W2037368532 hasConcept C2777077863 @default.
• W2037368532 hasConcept C2777575956 @default.
• W2037368532 hasConcept C2778690821 @default.
• W2037368532 hasConcept C2779281246 @default.
• W2037368532 hasConcept C2780801004 @default.
• W2037368532 hasConcept C2780841837 @default.
• W2037368532 hasConcept C55493867 @default.
• W2037368532 hasConcept C71924100 @default.
• W2037368532 hasConcept C86803240 @default.
• W2037368532 hasConcept C8891405 @default.
• W2037368532 hasConceptScore W2037368532C126322002 @default.
• W2037368532 hasConceptScore W2037368532C134018914 @default.
• W2037368532 hasConceptScore W2037368532C150903083 @default.
• W2037368532 hasConceptScore W2037368532C185592680 @default.
• W2037368532 hasConceptScore W2037368532C202751555 @default.
• W2037368532 hasConceptScore W2037368532C203014093 @default.
• W2037368532 hasConceptScore W2037368532C207001950 @default.
• W2037368532 hasConceptScore W2037368532C2777077863 @default.
• W2037368532 hasConceptScore W2037368532C2777575956 @default.
• W2037368532 hasConceptScore W2037368532C2778690821 @default.
• W2037368532 hasConceptScore W2037368532C2779281246 @default.
• W2037368532 hasConceptScore W2037368532C2780801004 @default.
• W2037368532 hasConceptScore W2037368532C2780841837 @default.
• W2037368532 hasConceptScore W2037368532C55493867 @default.
• W2037368532 hasConceptScore W2037368532C71924100 @default.
• W2037368532 hasConceptScore W2037368532C86803240 @default.
• W2037368532 hasConceptScore W2037368532C8891405 @default.
• W2037368532 hasIssue "4" @default.
• W2037368532 hasLocation W20373685321 @default.
• W2037368532 hasLocation W20373685322 @default.
• W2037368532 hasOpenAccess W2037368532 @default.
• W2037368532 hasPrimaryLocation W20373685321 @default.
• W2037368532 hasRelatedWork W2150503314 @default.
• W2037368532 hasRelatedWork W2384738060 @default.
• W2037368532 hasRelatedWork W2416097977 @default.

• next