FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037369568> ?p ?o ?g. }

• W2037369568 endingPage "640" @default.
• W2037369568 startingPage "631" @default.
• W2037369568 abstract "The human cytochrome P450 2J2 (CYP2J2) generates cytoprotective epoxyeicosatrienoic acids from arachidonic acid. Expression of CYP2J2 is decreased in hypoxia, and the resultant decrease in CYP2J2-derived epoxyeicosanoids may contribute to the pathogenesis of cardiac ischaemia. Recent studies have indicated that AP-1 (activator protein-1) regulates CYP2J2 expression in normoxia and hypoxia. Down-regulation of CYP2J2 in hypoxic HepG2 cells was closely associated with the up-regulation of c-fos and transient transfection analysis demonstrated that c-Fos abolishes the activation of CYP2J2 by the AP-1 protein c-Jun. Deletion of the region between nt −122 and −50 upstream of the start codon in CYP2J2 prevented c-Jun transactivation. In this study we demonstrate that the sequence at −105/−95 is a major regulatory element that binds c-Jun and has a prominent role in CYP2J2 gene transactivation. Mutagenesis of both the −105/−95 region and the previously identified element at −56/−63 was required for complete loss of transactivation by c-Jun; separate mutagenesis of the −105/−95 element or, to a lesser extent, the −56/−63 element resulted in a partial loss of gene activation. In contrast to the behaviour of the −56/−63 element, c-Jun homodimers and c-Fos/c-Jun heterodimers bound to the −105/−95 element. These findings demonstrate that the c-Jun-responsive module between −122 and −50 in the CYP2J2 proximal promoter contains an atypical AP-1 element at −105/−95 that has a major role in c-Jun transactivation and acts in conjunction with the −56/−63 element to regulate expression." @default.
• W2037369568 created "2016-06-24" @default.
• W2037369568 creator A5003967548 @default.
• W2037369568 creator A5050018222 @default.
• W2037369568 date "2005-10-25" @default.
• W2037369568 modified "2023-10-17" @default.
• W2037369568 title "Characterization of a c-Jun-responsive module in the 5′-flank of the human <i>CYP2J2</i> gene that regulates transactivation" @default.
• W2037369568 cites W1037454573 @default.
• W2037369568 cites W1588470721 @default.
• W2037369568 cites W1748292009 @default.
• W2037369568 cites W1775749144 @default.
• W2037369568 cites W1890692713 @default.
• W2037369568 cites W1913730804 @default.
• W2037369568 cites W1935478077 @default.
• W2037369568 cites W1967004332 @default.
• W2037369568 cites W1977159737 @default.
• W2037369568 cites W1987453246 @default.
• W2037369568 cites W1992303064 @default.
• W2037369568 cites W1995884552 @default.
• W2037369568 cites W2002485919 @default.
• W2037369568 cites W2015322148 @default.
• W2037369568 cites W2016730049 @default.
• W2037369568 cites W2023666553 @default.
• W2037369568 cites W2037113953 @default.
• W2037369568 cites W2044987829 @default.
• W2037369568 cites W2047866697 @default.
• W2037369568 cites W2053208432 @default.
• W2037369568 cites W2053544423 @default.
• W2037369568 cites W2058339758 @default.
• W2037369568 cites W2064879068 @default.
• W2037369568 cites W2068027420 @default.
• W2037369568 cites W2070366694 @default.
• W2037369568 cites W2093410626 @default.
• W2037369568 cites W2097998324 @default.
• W2037369568 cites W2098180441 @default.
• W2037369568 cites W2099709578 @default.
• W2037369568 cites W2107933591 @default.
• W2037369568 cites W2112294647 @default.
• W2037369568 cites W2112808044 @default.
• W2037369568 cites W2121216236 @default.
• W2037369568 cites W2126568266 @default.
• W2037369568 cites W2126947664 @default.
• W2037369568 cites W21419008 @default.
• W2037369568 cites W2150905382 @default.
• W2037369568 cites W2168823348 @default.
• W2037369568 cites W2171832412 @default.
• W2037369568 cites W2329404090 @default.
• W2037369568 cites W2410749618 @default.
• W2037369568 cites W2473472230 @default.
• W2037369568 doi "https://doi.org/10.1042/bj20050798" @default.
• W2037369568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1276964" @default.
• W2037369568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16008525" @default.
• W2037369568 hasPublicationYear "2005" @default.
• W2037369568 type Work @default.
• W2037369568 sameAs 2037369568 @default.
• W2037369568 citedByCount "19" @default.
• W2037369568 countsByYear W20373695682013 @default.
• W2037369568 countsByYear W20373695682014 @default.
• W2037369568 countsByYear W20373695682015 @default.
• W2037369568 countsByYear W20373695682016 @default.
• W2037369568 countsByYear W20373695682017 @default.
• W2037369568 countsByYear W20373695682018 @default.
• W2037369568 countsByYear W20373695682019 @default.
• W2037369568 countsByYear W20373695682022 @default.
• W2037369568 crossrefType "journal-article" @default.
• W2037369568 hasAuthorship W2037369568A5003967548 @default.
• W2037369568 hasAuthorship W2037369568A5050018222 @default.
• W2037369568 hasBestOaLocation W20373695682 @default.
• W2037369568 hasConcept C101762097 @default.
• W2037369568 hasConcept C104317684 @default.
• W2037369568 hasConcept C1292079 @default.
• W2037369568 hasConcept C132376346 @default.
• W2037369568 hasConcept C150194340 @default.
• W2037369568 hasConcept C153911025 @default.
• W2037369568 hasConcept C185592680 @default.
• W2037369568 hasConcept C55493867 @default.
• W2037369568 hasConcept C86803240 @default.
• W2037369568 hasConcept C95444343 @default.
• W2037369568 hasConceptScore W2037369568C101762097 @default.
• W2037369568 hasConceptScore W2037369568C104317684 @default.
• W2037369568 hasConceptScore W2037369568C1292079 @default.
• W2037369568 hasConceptScore W2037369568C132376346 @default.
• W2037369568 hasConceptScore W2037369568C150194340 @default.
• W2037369568 hasConceptScore W2037369568C153911025 @default.
• W2037369568 hasConceptScore W2037369568C185592680 @default.
• W2037369568 hasConceptScore W2037369568C55493867 @default.
• W2037369568 hasConceptScore W2037369568C86803240 @default.
• W2037369568 hasConceptScore W2037369568C95444343 @default.
• W2037369568 hasIssue "3" @default.
• W2037369568 hasLocation W20373695681 @default.
• W2037369568 hasLocation W20373695682 @default.
• W2037369568 hasLocation W20373695683 @default.
• W2037369568 hasLocation W20373695684 @default.
• W2037369568 hasOpenAccess W2037369568 @default.
• W2037369568 hasPrimaryLocation W20373695681 @default.
• W2037369568 hasRelatedWork W2004783548 @default.
• W2037369568 hasRelatedWork W2005057264 @default.
• W2037369568 hasRelatedWork W2008776444 @default.

• next