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- W2037380131 abstract "Abstract— Salmonella typhimurium strains with supX mutations are known to be sensitive to ultraviolet (254 nm) irradiation (UV) and to be protected by plasmid pKM101. Wild type (supX+) cells shut off their respiration after UV and are protected against their shutoff by pKM101. Respiration and survival studies were carried out on several supX strains with different genetic backgrounds. The supX strains shut off their respiration after low fluences of UV. Plasmid pKM101 protected a supX 83 (nonsense mutation) strain against respiration shutoff and killing but did not protect a supX35 (deletion mutation) strain against respiration shutoff or killing. When each of the two supX genes were in the genetic backgrounds of the other, however, full protection was provided by pKM101. The supX35 strain not protected by pKM101 may have accummulated a modifying mutation. The supX locus is identical with one specifying topoisomerase I which removes negative superhelical turns from DNA. In the absence of this enzyme transcription of the DNA is increased. It is proposed that the exaggerated shutoff of respiration and increased killing of supX cells occurs because of the greater ease of transcription of an operon involved in UV-induced respiration shutoff." @default.
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- W2037380131 date "1983-09-01" @default.
- W2037380131 modified "2023-10-17" @default.
- W2037380131 title "ROLE OF THE supX GENE IN SENSITIZING Salmonella typhimurium CELLS TO RESPIRATION SHUTOFF INDUCED BY FAR ULTRAVIOLET IRRADIATION" @default.
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- W2037380131 doi "https://doi.org/10.1111/j.1751-1097.1983.tb02676.x" @default.
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