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- W2037392562 abstract "Severe anaemia is a rare, unexplained, side effect of azathioprine therapy. We report here such a case associated with a previously unreported abnormality in azathioprine metabolism. A 57 year old man on azathioprine therapy, for a presumed collagen vascular disease, developed severe megaloblastic anaemia. This resolved on cessation of azathioprine treatment. A very high concentration of an azathioprine metabolite, 6-thioguanine nucleotide, was found in the patient's red blood cells and this was confirmed by subsequent rechallenge with a single dose of 50 mg azathioprine." @default.
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- W2037392562 date "1984-02-01" @default.
- W2037392562 modified "2023-10-14" @default.
- W2037392562 title "Severe megaloblastic anaemia associated with abnormal azathioprine metabolism." @default.
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- W2037392562 doi "https://doi.org/10.1111/j.1365-2125.1984.tb02333.x" @default.
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