Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037396572> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W2037396572 endingPage "1296" @default.
- W2037396572 startingPage "1295" @default.
- W2037396572 abstract "During the last decade, mutations in the glucokinase and hepatic nuclear factor (HNF) genes were found to cause maturity-onset diabetes of the young (MODY), which is characterized by a dominant autosomal mode of inheritance, high penetrance, lack of cardiovascular morbidity, and defective insulin response to glucose stimulus combined with normal, or even supranormal, insulin sensitivity (1,2). Most forms of MODY are caused by mutations in transcription factors such as HNF-1α (MODY3), HNF-4α (MODY1), insulin promoter factor (IPF)-1 (MODY4), HNF-1β (MODY5), or glukokinase (MODY2) (1). Although the precise mechanisms by which mutations in these transcription factors cause diabetes are not known, they are thought to involve transcription of a number of β-cell genes (3). Despite the fact that the defects are already present at birth, diabetes is rarely manifested at birth. Instead, the monogenic forms of diabetes are in fact heterogeneous with respect to age at diabetes diagnosis and severity of the insulin secretory defect (1). It has been hypothesized that high insulin sensitivity could maintain normoglycemia, despite minimal insulin secretory capacity, and that any deterioration in insulin sensitivity could result in hyperglycemia. This is supported by frequent deterioration of glucose tolerance during puberty or pregnancy.The age at diagnosis of diabetes …" @default.
- W2037396572 created "2016-06-24" @default.
- W2037396572 creator A5061973111 @default.
- W2037396572 creator A5074771810 @default.
- W2037396572 date "2003-04-01" @default.
- W2037396572 modified "2023-09-26" @default.
- W2037396572 title "Intrauterine Hyperglycemia Modifying the Development of (Monogenic) Diabetes?" @default.
- W2037396572 cites W1982136783 @default.
- W2037396572 cites W1987152954 @default.
- W2037396572 cites W1995269929 @default.
- W2037396572 cites W2011262822 @default.
- W2037396572 cites W2015031894 @default.
- W2037396572 cites W2022910286 @default.
- W2037396572 cites W2046889691 @default.
- W2037396572 cites W2114147184 @default.
- W2037396572 cites W2160570394 @default.
- W2037396572 cites W2167420234 @default.
- W2037396572 doi "https://doi.org/10.2337/diacare.26.4.1295" @default.
- W2037396572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12663611" @default.
- W2037396572 hasPublicationYear "2003" @default.
- W2037396572 type Work @default.
- W2037396572 sameAs 2037396572 @default.
- W2037396572 citedByCount "1" @default.
- W2037396572 countsByYear W20373965722020 @default.
- W2037396572 crossrefType "journal-article" @default.
- W2037396572 hasAuthorship W2037396572A5061973111 @default.
- W2037396572 hasAuthorship W2037396572A5074771810 @default.
- W2037396572 hasBestOaLocation W20373965721 @default.
- W2037396572 hasConcept C126322002 @default.
- W2037396572 hasConcept C134018914 @default.
- W2037396572 hasConcept C555293320 @default.
- W2037396572 hasConcept C71924100 @default.
- W2037396572 hasConceptScore W2037396572C126322002 @default.
- W2037396572 hasConceptScore W2037396572C134018914 @default.
- W2037396572 hasConceptScore W2037396572C555293320 @default.
- W2037396572 hasConceptScore W2037396572C71924100 @default.
- W2037396572 hasIssue "4" @default.
- W2037396572 hasLocation W20373965721 @default.
- W2037396572 hasLocation W20373965722 @default.
- W2037396572 hasOpenAccess W2037396572 @default.
- W2037396572 hasPrimaryLocation W20373965721 @default.
- W2037396572 hasRelatedWork W1966504330 @default.
- W2037396572 hasRelatedWork W1966775726 @default.
- W2037396572 hasRelatedWork W1974041167 @default.
- W2037396572 hasRelatedWork W1979139803 @default.
- W2037396572 hasRelatedWork W2030889776 @default.
- W2037396572 hasRelatedWork W2037631372 @default.
- W2037396572 hasRelatedWork W2040058909 @default.
- W2037396572 hasRelatedWork W2132898409 @default.
- W2037396572 hasRelatedWork W2748952813 @default.
- W2037396572 hasRelatedWork W4249176446 @default.
- W2037396572 hasVolume "26" @default.
- W2037396572 isParatext "false" @default.
- W2037396572 isRetracted "false" @default.
- W2037396572 magId "2037396572" @default.
- W2037396572 workType "article" @default.