Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037397399> ?p ?o ?g. }
- W2037397399 endingPage "189" @default.
- W2037397399 startingPage "177" @default.
- W2037397399 abstract "Upon recognizing cognate antigen, B cells mobilize multiple cellular apparatuses to propagate an optimal response. Antigen binding is transduced into cytoplasmic signaling events through B-cell antigen receptor (BCR)-based signalosomes at the B-cell surface. BCR signalosomes are dynamic and transient and are subsequently endocytosed for antigen processing. The function of BCR signalosomes is one of the determining factors for the fate of B cells: clonal expansion, anergy, or apoptosis. Accumulating evidence underscores the importance of the actin cytoskeleton in B-cell activation. We have begun to appreciate the role of actin dynamics in regulating BCR-mediated tonic signaling and the formation of BCR signalosomes. Our recent studies reveal an additional function of the actin cytoskeleton in the downregulation of BCR signaling, consequently contributing to the generation and maintenance of B-cell self-tolerance. In this review, we discuss how actin remodels its organization and dynamics in close coordination with BCR signaling and how actin remodeling in turn amplifies the activation and subsequent downregulation process of BCR signaling, providing vital feedback for optimal BCR activation." @default.
- W2037397399 created "2016-06-24" @default.
- W2037397399 creator A5004279067 @default.
- W2037397399 creator A5014362815 @default.
- W2037397399 creator A5014421246 @default.
- W2037397399 creator A5038322237 @default.
- W2037397399 creator A5061697108 @default.
- W2037397399 creator A5088656181 @default.
- W2037397399 date "2013-10-10" @default.
- W2037397399 modified "2023-10-16" @default.
- W2037397399 title "Actin-mediated feedback loops in B-cell receptor signaling" @default.
- W2037397399 cites W112651372 @default.
- W2037397399 cites W126114442 @default.
- W2037397399 cites W1481677180 @default.
- W2037397399 cites W1490990707 @default.
- W2037397399 cites W1519766162 @default.
- W2037397399 cites W1538100539 @default.
- W2037397399 cites W1564987511 @default.
- W2037397399 cites W1585443123 @default.
- W2037397399 cites W1594019696 @default.
- W2037397399 cites W1595108998 @default.
- W2037397399 cites W1599980536 @default.
- W2037397399 cites W1605957976 @default.
- W2037397399 cites W1613664762 @default.
- W2037397399 cites W1620395613 @default.
- W2037397399 cites W1640813462 @default.
- W2037397399 cites W1785108662 @default.
- W2037397399 cites W1918941425 @default.
- W2037397399 cites W1927916230 @default.
- W2037397399 cites W1967139887 @default.
- W2037397399 cites W1969312703 @default.
- W2037397399 cites W1970594700 @default.
- W2037397399 cites W1973406789 @default.
- W2037397399 cites W1976100793 @default.
- W2037397399 cites W1977888015 @default.
- W2037397399 cites W1979059478 @default.
- W2037397399 cites W1982008474 @default.
- W2037397399 cites W1982022868 @default.
- W2037397399 cites W1982643313 @default.
- W2037397399 cites W1984838238 @default.
- W2037397399 cites W1990689709 @default.
- W2037397399 cites W1997228602 @default.
- W2037397399 cites W2002892911 @default.
- W2037397399 cites W2011444435 @default.
- W2037397399 cites W2015369991 @default.
- W2037397399 cites W2018521012 @default.
- W2037397399 cites W2019182330 @default.
- W2037397399 cites W2025036258 @default.
- W2037397399 cites W2029022457 @default.
- W2037397399 cites W2030879362 @default.
- W2037397399 cites W2031183440 @default.
- W2037397399 cites W2036574499 @default.
- W2037397399 cites W2037584275 @default.
- W2037397399 cites W2039073711 @default.
- W2037397399 cites W2041437399 @default.
- W2037397399 cites W2042015318 @default.
- W2037397399 cites W2042202484 @default.
- W2037397399 cites W2044654378 @default.
- W2037397399 cites W2046762204 @default.
- W2037397399 cites W2047167078 @default.
- W2037397399 cites W2047321895 @default.
- W2037397399 cites W2051341672 @default.
- W2037397399 cites W2053508150 @default.
- W2037397399 cites W2054526083 @default.
- W2037397399 cites W2056462157 @default.
- W2037397399 cites W2061900998 @default.
- W2037397399 cites W2061904645 @default.
- W2037397399 cites W2063192139 @default.
- W2037397399 cites W2069393436 @default.
- W2037397399 cites W2070638961 @default.
- W2037397399 cites W2072297269 @default.
- W2037397399 cites W2072953299 @default.
- W2037397399 cites W2074143045 @default.
- W2037397399 cites W2076808220 @default.
- W2037397399 cites W2078410413 @default.
- W2037397399 cites W2079980816 @default.
- W2037397399 cites W2082024168 @default.
- W2037397399 cites W2083735008 @default.
- W2037397399 cites W2085549346 @default.
- W2037397399 cites W2086464445 @default.
- W2037397399 cites W2087419010 @default.
- W2037397399 cites W2088364573 @default.
- W2037397399 cites W2088741694 @default.
- W2037397399 cites W2092650508 @default.
- W2037397399 cites W2094577052 @default.
- W2037397399 cites W2095034388 @default.
- W2037397399 cites W2099490105 @default.
- W2037397399 cites W2099555659 @default.
- W2037397399 cites W2101773396 @default.
- W2037397399 cites W2102636907 @default.
- W2037397399 cites W2103689369 @default.
- W2037397399 cites W2109675261 @default.
- W2037397399 cites W2114560611 @default.
- W2037397399 cites W2114629549 @default.
- W2037397399 cites W2114802325 @default.
- W2037397399 cites W2114833837 @default.
- W2037397399 cites W2117248853 @default.
- W2037397399 cites W2119517654 @default.