FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037402811> ?p ?o ?g. }

• W2037402811 endingPage "586" @default.
• W2037402811 startingPage "580" @default.
• W2037402811 abstract "Background context Recombinant human platelet-derived growth factor-BB (rhPDGF-BB) homodimer is a chemotactic, mitogenic, and angiogenic factor expressed by platelets. This biological triad is profoundly important in the bone regenerative cascade. Therefore, the expectation was that rhPDGF-BB locally administered to designated lumbar vertebrae in a soluble Type I bovine collagen/β-tricalcium phosphate (β-TCP) injectable paste would have an osteoanabolic effect. Purpose The study objective focused on safety and efficacy of the rhPDGF-BB and soluble Type I bovine collagen/β-TCP to increase bone density when injected directly into specific lumbar vertebral bodies in elderly (17- to 18-year-old) female baboons. Study design/setting The study was designed to determine whether vertebral bone mineral density (BMD) in aged female baboons could be increased by locally administering recombinant rhPDGF-BB combined in a soluble Type I bovine collagen/β-TCP paste formulation. Methods A total of six baboons were divided equally into two groups. Group 1 received 1.0 mg/mL rhPDGF-BB in 20 mM sodium acetate plus soluble Type I bovine collagen/β-TCP. Group 2 was treated with 20 mM sodium acetate plus soluble Type I bovine collagen/β-TCP. Baboons in each group also received a sham surgery. Surgery was conducted using a percutaneous, fluoroscopically guided approach, and quantitative computed tomography (qCT) and radiographs were done at dedicated time periods. The qCT was used to determine volumetric BMD (vBMD). At euthanasia (36-week posttreatment), lumbar vertebrae were recovered and analyzed by qCT scans and histology. Funds were received to support this work from BioMimetic Therapeutics, Inc. The device that is the subject of this manuscript is not Food Drug Administration approved for this indication and is not commercially available in the United States. Results The qCT and histopathological data suggested that vBMD and bone morphology increased significantly in the lumbar vertebrae treated with the rhPDGF-BB–containing composition. Conclusions Bone mineral density and bone morphology quality of lumbar vertebrae in aged female baboons were improved by direct injection of rhPDGF-BB in a soluble Type I bovine collagen/β-TCP paste. Throughout the course of the study, there were neither local nor systemic adverse effects." @default.
• W2037402811 created "2016-06-24" @default.
• W2037402811 creator A5001174035 @default.
• W2037402811 creator A5002877422 @default.
• W2037402811 creator A5022070942 @default.
• W2037402811 creator A5070210677 @default.
• W2037402811 creator A5073060614 @default.
• W2037402811 creator A5075323279 @default.
• W2037402811 date "2013-05-01" @default.
• W2037402811 modified "2023-09-24" @default.
• W2037402811 title "Percutaneous injection of Augment Injectable Bone Graft (rhPDGF-BB and β-tricalcium phosphate [β-TCP]/bovine Type I collagen matrix) increases vertebral bone mineral density in geriatric female baboons" @default.
• W2037402811 cites W15225809 @default.
• W2037402811 cites W1973631902 @default.
• W2037402811 cites W1977070858 @default.
• W2037402811 cites W1981478725 @default.
• W2037402811 cites W1985258446 @default.
• W2037402811 cites W1986997109 @default.
• W2037402811 cites W1994287631 @default.
• W2037402811 cites W2010777478 @default.
• W2037402811 cites W2033419489 @default.
• W2037402811 cites W2035817691 @default.
• W2037402811 cites W2050273933 @default.
• W2037402811 cites W2051271037 @default.
• W2037402811 cites W2055426312 @default.
• W2037402811 cites W2063301695 @default.
• W2037402811 cites W2073260359 @default.
• W2037402811 cites W2078002235 @default.
• W2037402811 cites W2108156722 @default.
• W2037402811 cites W2115641074 @default.
• W2037402811 cites W2133202345 @default.
• W2037402811 cites W2133584055 @default.
• W2037402811 cites W2153389583 @default.
• W2037402811 cites W2413046665 @default.
• W2037402811 cites W8638124 @default.
• W2037402811 doi "https://doi.org/10.1016/j.spinee.2013.02.029" @default.
• W2037402811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23541446" @default.
• W2037402811 hasPublicationYear "2013" @default.
• W2037402811 type Work @default.
• W2037402811 sameAs 2037402811 @default.
• W2037402811 citedByCount "6" @default.
• W2037402811 countsByYear W20374028112014 @default.
• W2037402811 countsByYear W20374028112016 @default.
• W2037402811 countsByYear W20374028112017 @default.
• W2037402811 countsByYear W20374028112019 @default.
• W2037402811 countsByYear W20374028112021 @default.
• W2037402811 countsByYear W20374028112023 @default.
• W2037402811 crossrefType "journal-article" @default.
• W2037402811 hasAuthorship W2037402811A5001174035 @default.
• W2037402811 hasAuthorship W2037402811A5002877422 @default.
• W2037402811 hasAuthorship W2037402811A5022070942 @default.
• W2037402811 hasAuthorship W2037402811A5070210677 @default.
• W2037402811 hasAuthorship W2037402811A5073060614 @default.
• W2037402811 hasAuthorship W2037402811A5075323279 @default.
• W2037402811 hasConcept C126322002 @default.
• W2037402811 hasConcept C126894567 @default.
• W2037402811 hasConcept C141071460 @default.
• W2037402811 hasConcept C151730666 @default.
• W2037402811 hasConcept C2776541429 @default.
• W2037402811 hasConcept C2776886416 @default.
• W2037402811 hasConcept C2777425516 @default.
• W2037402811 hasConcept C2779329777 @default.
• W2037402811 hasConcept C2779343474 @default.
• W2037402811 hasConcept C44575665 @default.
• W2037402811 hasConcept C71924100 @default.
• W2037402811 hasConcept C86803240 @default.
• W2037402811 hasConceptScore W2037402811C126322002 @default.
• W2037402811 hasConceptScore W2037402811C126894567 @default.
• W2037402811 hasConceptScore W2037402811C141071460 @default.
• W2037402811 hasConceptScore W2037402811C151730666 @default.
• W2037402811 hasConceptScore W2037402811C2776541429 @default.
• W2037402811 hasConceptScore W2037402811C2776886416 @default.
• W2037402811 hasConceptScore W2037402811C2777425516 @default.
• W2037402811 hasConceptScore W2037402811C2779329777 @default.
• W2037402811 hasConceptScore W2037402811C2779343474 @default.
• W2037402811 hasConceptScore W2037402811C44575665 @default.
• W2037402811 hasConceptScore W2037402811C71924100 @default.
• W2037402811 hasConceptScore W2037402811C86803240 @default.
• W2037402811 hasIssue "5" @default.
• W2037402811 hasLocation W20374028111 @default.
• W2037402811 hasLocation W20374028112 @default.
• W2037402811 hasOpenAccess W2037402811 @default.
• W2037402811 hasPrimaryLocation W20374028111 @default.
• W2037402811 hasRelatedWork W1492644754 @default.
• W2037402811 hasRelatedWork W2046596180 @default.
• W2037402811 hasRelatedWork W2046809491 @default.
• W2037402811 hasRelatedWork W2053289625 @default.
• W2037402811 hasRelatedWork W2090408873 @default.
• W2037402811 hasRelatedWork W2092013139 @default.
• W2037402811 hasRelatedWork W2388525460 @default.
• W2037402811 hasRelatedWork W2394261080 @default.
• W2037402811 hasRelatedWork W2538840796 @default.
• W2037402811 hasRelatedWork W2982459368 @default.
• W2037402811 hasVolume "13" @default.
• W2037402811 isParatext "false" @default.
• W2037402811 isRetracted "false" @default.
• W2037402811 magId "2037402811" @default.
• W2037402811 workType "article" @default.