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- W2037415532 abstract "Using data from a number of recent in vitro selection experiments, general conclusions have been drawn about the shapes of landscapes that map nucleic acid sequences to functions (in particular, the ability to bind a ligand). It appears that local optima on these landscapes are dispersed; that is, that there are a variety of sequences that can bind to a given ligand. In addition, though, there are usually one or two apparently global optima. A comparison of aptamer shapes suggests that nucleic acids can easily form simple pockets by using short helical segments. These results have implications for the origin and evolution of metabolism: short nucleic acids may be much better suited to ligand-binding than short peptides or other biopolymers." @default.
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- W2037415532 date "1994-09-01" @default.
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- W2037415532 title "The RNA world. Empirical explorations of sequence space: Host-guest chemistry in the RNA world" @default.
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- W2037415532 doi "https://doi.org/10.1002/bbpc.19940980907" @default.
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