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• W2037441873 abstract "Background: It has been shown that the concentration of serum free thyroxine (FT4) is independently associated with atrial fibrillation (AF), even in euthyroid persons. This study investigated the effect of a high-normal level of FT4 on recurrence after catheter ablation of AF. Methods and Results: The 244 consecutive patients with paroxysmal AF and who underwent circumferential pulmonary vein isolation (PVI) were prospectively enrolled. Exclusion criteria included prior or current thyroid dysfunction on admission, amiodarone medication for 3 months before admission. After a mean follow-up of 416±204 (91-856) days, the recurrence rates were 14.8%, 23.0%, 33.3%, 38.7% from the lowest FT4 quartile to the highest FT4 quartile, respectively (P=0.016). After adjustment for age, sex, left atrial diameter, and PVI, there was an increased risk of recurrence in the subjects with the highest FT4 quartile compared with those with the lowest quartile (hazard ratio 3.31, 95% confidence interval 1.45-7.54, P=0.004). As a continuous variable, FT4 was also an independent predictor of recurrence (hazard ratio 1.10, 95% confidence interval 1.02-1.18, P=0.016). Conclusions: Patients with high-normal thyroid function were at an increased risk of AF recurrence after catheter ablation. (Circ J 2010; 74: 1316 - 1321)" @default.
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• W2037441873 date "2010-01-01" @default.
• W2037441873 modified "2023-10-17" @default.
• W2037441873 title "High-Normal Thyroid Function and Risk of Recurrence of Atrial Fibrillation After Catheter Ablation" @default.
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• W2037441873 doi "https://doi.org/10.1253/circj.cj-09-0708" @default.
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