FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037446002> ?p ?o ?g. }

• W2037446002 endingPage "518" @default.
• W2037446002 startingPage "505" @default.
• W2037446002 abstract "Insulin-like growth factor messenger RNAs are expressed in adult rat brain. However, little is known about the effects of aging on the expression of the insulin-like growth factors, their receptors, and their binding proteins in different regions of rat brain. The goal of the current study was to assess whether there is altered expression of the insulin-like growth factor system during normal aging in the hippocampal formation, a region particularly vulnerable to the aging process. A spatial learning task in the Morris water maze was used to assess the cognitive status of young (7-8-month-old) and aged (28-29-month-old) male Long-Evans rats. Sites of expression and abundance of insulin-like growth factor-I, type 1 insulin-like growth factor receptor, and insulin-like growth factor binding protein-4 messenger RNAs were then examined by in situ hybridization histochemistry and solution or northern blot hybridization assays. In situ hybridization histochemistry revealed no qualitative differences in the regional distribution of insulin-like growth factor-I, type 1 receptor, and insulin-like growth factor binding protein-4 messenger RNAs within the hippocampal formation of young and aged rats. However, quantitative analysis of messenger RNA abundance in hippocampal tissue homogenates showed a significant age-related increase in type 1 receptor messenger RNA (n = 25; t = -2.5; P < 0.02). Furthermore, linear regression analysis indicated that type 1 receptor messenger RNA abundance was significantly correlated with spatial learning impairment in the water maze (r = 0.44; P < 0.03) such that greater behavioral impairment was associated with higher type 1 receptor messenger RNA levels in the hippocampal formation. Neither insulin-like growth factor-I nor insulin-like growth factor binding protein-4 messenger RNA abundance was related to age or behavior. However, linear regression revealed a negative correlation between insulin-like growth factor-I messenger RNA abundance and type 1 receptor messenger RNA abundance in aged hippocampus (r = -0.72, P < 0.01). These data indicate that increased hippocampal expression of type 1 receptor messenger RNA is associated with aging and cognitive decline. The correlation between type 1 receptor and insulin-like growth factor-I messenger RNA abundance in the hippocampal formation of aged rats suggests that insulin-like growth factor availability may influence type 1 receptor expression. However, because no overall age difference was found in the amount of insulin-like growth factor-I messenger RNA in the hippocampal formation, decreased insulin-like growth factor from other sources such as the cerebrospinal fluid and the peripheral circulation may be involved in up-regulating type 1 receptor messenger RNA. Alternatively, type 1 receptor messenger RNA regulation may be part of a trophic response to the degenerative and regenerative events that occur within the hippocampal formation during aging." @default.
• W2037446002 created "2016-06-24" @default.
• W2037446002 creator A5028703965 @default.
• W2037446002 creator A5034848117 @default.
• W2037446002 creator A5073031803 @default.
• W2037446002 date "1996-05-01" @default.
• W2037446002 modified "2023-10-07" @default.
• W2037446002 title "Increased expression of type 1 insulin-like growth factor receptor messenger rna in rat hippocampal formation is associated with aging and behavioral impairment" @default.
• W2037446002 cites W1042220629 @default.
• W2037446002 cites W147752543 @default.
• W2037446002 cites W1483718240 @default.
• W2037446002 cites W1507370673 @default.
• W2037446002 cites W1509427422 @default.
• W2037446002 cites W1602004204 @default.
• W2037446002 cites W1959209906 @default.
• W2037446002 cites W1971325859 @default.
• W2037446002 cites W1972988863 @default.
• W2037446002 cites W1976136395 @default.
• W2037446002 cites W1978685355 @default.
• W2037446002 cites W1982911877 @default.
• W2037446002 cites W1985221567 @default.
• W2037446002 cites W1991463397 @default.
• W2037446002 cites W1995361556 @default.
• W2037446002 cites W1996542763 @default.
• W2037446002 cites W1997524583 @default.
• W2037446002 cites W1997650811 @default.
• W2037446002 cites W2003432669 @default.
• W2037446002 cites W2008288388 @default.
• W2037446002 cites W2009267571 @default.
• W2037446002 cites W2014212152 @default.
• W2037446002 cites W2021270398 @default.
• W2037446002 cites W2023634037 @default.
• W2037446002 cites W2027260046 @default.
• W2037446002 cites W2029686424 @default.
• W2037446002 cites W2030723648 @default.
• W2037446002 cites W2030997373 @default.
• W2037446002 cites W2034239785 @default.
• W2037446002 cites W2037908014 @default.
• W2037446002 cites W2038125023 @default.
• W2037446002 cites W2040833439 @default.
• W2037446002 cites W2050992850 @default.
• W2037446002 cites W2053459336 @default.
• W2037446002 cites W2055869269 @default.
• W2037446002 cites W2058771161 @default.
• W2037446002 cites W2060040319 @default.
• W2037446002 cites W2063552262 @default.
• W2037446002 cites W2065995727 @default.
• W2037446002 cites W2072158957 @default.
• W2037446002 cites W2073355272 @default.
• W2037446002 cites W2075592280 @default.
• W2037446002 cites W2076262353 @default.
• W2037446002 cites W2078288069 @default.
• W2037446002 cites W2078680796 @default.
• W2037446002 cites W2078919405 @default.
• W2037446002 cites W2079486891 @default.
• W2037446002 cites W2085921234 @default.
• W2037446002 cites W2089896289 @default.
• W2037446002 cites W2092638493 @default.
• W2037446002 cites W2093351124 @default.
• W2037446002 cites W2094569366 @default.
• W2037446002 cites W2104269213 @default.
• W2037446002 cites W2106767413 @default.
• W2037446002 cites W2117120152 @default.
• W2037446002 cites W2126974689 @default.
• W2037446002 cites W2127619125 @default.
• W2037446002 cites W2153045976 @default.
• W2037446002 cites W2153647147 @default.
• W2037446002 cites W2169473035 @default.
• W2037446002 cites W2335594369 @default.
• W2037446002 cites W4230636610 @default.
• W2037446002 cites W4231067551 @default.
• W2037446002 cites W4234837689 @default.
• W2037446002 cites W4238648092 @default.
• W2037446002 cites W4244259619 @default.
• W2037446002 doi "https://doi.org/10.1016/0306-4522(95)00524-2" @default.
• W2037446002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8737419" @default.
• W2037446002 hasPublicationYear "1996" @default.
• W2037446002 type Work @default.
• W2037446002 sameAs 2037446002 @default.
• W2037446002 citedByCount "50" @default.
• W2037446002 countsByYear W20374460022012 @default.
• W2037446002 countsByYear W20374460022014 @default.
• W2037446002 countsByYear W20374460022016 @default.
• W2037446002 countsByYear W20374460022018 @default.
• W2037446002 countsByYear W20374460022021 @default.
• W2037446002 countsByYear W20374460022022 @default.
• W2037446002 crossrefType "journal-article" @default.
• W2037446002 hasAuthorship W2037446002A5028703965 @default.
• W2037446002 hasAuthorship W2037446002A5034848117 @default.
• W2037446002 hasAuthorship W2037446002A5073031803 @default.
• W2037446002 hasConcept C104317684 @default.
• W2037446002 hasConcept C105580179 @default.
• W2037446002 hasConcept C112446052 @default.
• W2037446002 hasConcept C126322002 @default.
• W2037446002 hasConcept C134018914 @default.
• W2037446002 hasConcept C144174609 @default.
• W2037446002 hasConcept C148762608 @default.
• W2037446002 hasConcept C170493617 @default.

• next