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- W2037447621 abstract "Inhibition of mutant B-Raf signaling, through either direct inhibition of the enzyme or inhibition of MEK, the direct substrate of Raf, has been demonstrated preclinically to inhibit tumor growth. Very recently, treatment of B-Raf mutant melanoma patients with a selective B-Raf inhibitor has resulted in promising preliminary evidence of antitumor activity. This article describes the design and optimization of tetrahydronaphthalene-derived compounds as potent inhibitors of the Raf pathway in vitro and in vivo. These compounds possess good pharmacokinetic properties in rodents and inhibit B-Raf mutant tumor growth in mouse xenograft models." @default.
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- W2037447621 date "2011-02-22" @default.
- W2037447621 modified "2023-10-10" @default.
- W2037447621 title "Design and Optimization of Potent and Orally Bioavailable Tetrahydronaphthalene Raf Inhibitors" @default.
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- W2037447621 doi "https://doi.org/10.1021/jm101479y" @default.
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