FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037449788> ?p ?o ?g. }

• W2037449788 endingPage "174" @default.
• W2037449788 startingPage "168" @default.
• W2037449788 abstract "Polyglutamine (polyQ) repeat diseases are neurodegenerative ailments elicited by glutamine-encoding CAG nucleotide expansions within endogenous human genes. Despite efforts to understand the basis of these diseases, the precise mechanism of cell death remains stubbornly unclear. Much of the data seem to be consistent with a model in which toxicity is an inherent property of the polyQ repeat, whereas host protein sequences surrounding the polyQ expansion modulate severity, age of onset, and cell specificity. Recently, a gene, pqn-41, encoding a glutamine-rich protein, was found to promote normally occurring non-apoptotic cell death in Caenorhabditis elegans. Here we review evidence for toxic and modulatory roles for polyQ repeats and their host proteins, respectively, and suggest similarities with pqn-41 function. We explore the hypothesis that toxicity mediated by glutamine-rich motifs may be important not only in pathology, but also in normal development." @default.
• W2037449788 created "2016-06-24" @default.
• W2037449788 creator A5009110539 @default.
• W2037449788 creator A5028738022 @default.
• W2037449788 creator A5065822923 @default.
• W2037449788 date "2013-04-01" @default.
• W2037449788 modified "2023-10-14" @default.
• W2037449788 title "PolyQ disease: misfiring of a developmental cell death program?" @default.
• W2037449788 cites W1509995007 @default.
• W2037449788 cites W1604791477 @default.
• W2037449788 cites W1872122 @default.
• W2037449788 cites W1969042688 @default.
• W2037449788 cites W1969331809 @default.
• W2037449788 cites W1970254771 @default.
• W2037449788 cites W1972818610 @default.
• W2037449788 cites W1975715530 @default.
• W2037449788 cites W1978677176 @default.
• W2037449788 cites W1982138826 @default.
• W2037449788 cites W1984944970 @default.
• W2037449788 cites W1985836613 @default.
• W2037449788 cites W1988110501 @default.
• W2037449788 cites W1988130372 @default.
• W2037449788 cites W1989619236 @default.
• W2037449788 cites W1989684700 @default.
• W2037449788 cites W1991714330 @default.
• W2037449788 cites W1994947657 @default.
• W2037449788 cites W1996565611 @default.
• W2037449788 cites W1999783230 @default.
• W2037449788 cites W2000048736 @default.
• W2037449788 cites W2002519661 @default.
• W2037449788 cites W2003618511 @default.
• W2037449788 cites W2004559462 @default.
• W2037449788 cites W2008526580 @default.
• W2037449788 cites W2010684046 @default.
• W2037449788 cites W2012385113 @default.
• W2037449788 cites W2013452556 @default.
• W2037449788 cites W2013820019 @default.
• W2037449788 cites W2016332933 @default.
• W2037449788 cites W2017754448 @default.
• W2037449788 cites W2021399948 @default.
• W2037449788 cites W2023566834 @default.
• W2037449788 cites W2027212523 @default.
• W2037449788 cites W2032255653 @default.
• W2037449788 cites W2032439710 @default.
• W2037449788 cites W2034329419 @default.
• W2037449788 cites W2035357631 @default.
• W2037449788 cites W2041436090 @default.
• W2037449788 cites W2042716629 @default.
• W2037449788 cites W2042800995 @default.
• W2037449788 cites W2043261840 @default.
• W2037449788 cites W2043519879 @default.
• W2037449788 cites W2048798282 @default.
• W2037449788 cites W2049334581 @default.
• W2037449788 cites W2051577979 @default.
• W2037449788 cites W2058174458 @default.
• W2037449788 cites W2058182560 @default.
• W2037449788 cites W2061803285 @default.
• W2037449788 cites W2062203120 @default.
• W2037449788 cites W2062682951 @default.
• W2037449788 cites W2067644428 @default.
• W2037449788 cites W2067680463 @default.
• W2037449788 cites W2071648839 @default.
• W2037449788 cites W2076534314 @default.
• W2037449788 cites W2077449710 @default.
• W2037449788 cites W2077886237 @default.
• W2037449788 cites W2078913984 @default.
• W2037449788 cites W2079196978 @default.
• W2037449788 cites W2081970457 @default.
• W2037449788 cites W2085707879 @default.
• W2037449788 cites W2092938083 @default.
• W2037449788 cites W2093479824 @default.
• W2037449788 cites W2097704427 @default.
• W2037449788 cites W2097729383 @default.
• W2037449788 cites W2101747555 @default.
• W2037449788 cites W2102026369 @default.
• W2037449788 cites W2104568818 @default.
• W2037449788 cites W2105303722 @default.
• W2037449788 cites W2106200048 @default.
• W2037449788 cites W2108570063 @default.
• W2037449788 cites W2108756893 @default.
• W2037449788 cites W2111531780 @default.
• W2037449788 cites W2111700402 @default.
• W2037449788 cites W2113333419 @default.
• W2037449788 cites W2113998330 @default.
• W2037449788 cites W2114546997 @default.
• W2037449788 cites W2117767677 @default.
• W2037449788 cites W2118958219 @default.
• W2037449788 cites W2120833057 @default.
• W2037449788 cites W2121642311 @default.
• W2037449788 cites W2122371316 @default.
• W2037449788 cites W2128341112 @default.
• W2037449788 cites W2128679613 @default.
• W2037449788 cites W2132216126 @default.
• W2037449788 cites W2135124405 @default.
• W2037449788 cites W2135732941 @default.
• W2037449788 cites W2135759997 @default.
• W2037449788 cites W2144706906 @default.
• W2037449788 cites W2144852146 @default.

• next