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• W2037454611 abstract "<b><i>Background:</i></b> The parasympathetic nervous system modulates the immune response in the abdominal-pelvic gut through the vagus nerve, which releases acetylcholine. This endogenous ligand acts on a7 nicotinic receptors expressed on immune cells. <b><i>Objective:</i></b> To study the mechanism of the production and regulation of cytokines in parasympathectomized and control hamsters during the development of amoebic liver abscesses (ALA) caused by <i>Entamoeba histolytica.</i><b><i>Methodology:</i></b> Six- to 8-week-old male hamsters with and without vagotomy were used in a model of ALA. The animals were infected with trophozoites (350,000; HM1:IMSS strain) via the intrahepatic route and sacrificed at 6, 12, and 24 h and at 2, 4, and 7 days postinfection. Immune parameters were recorded at each time point using morphometric techniques including immunofluorescence and immunohistochemistry assays. These parameters included signal transducer and activator of transcription 3 (STAT3) levels, pro- and anti-inflammatory cytokine levels, and nuclear factor-&#947;B (NF&#947;B) activation in neutrophils and macrophages. <b><i>Results:</i></b> Compared to the control groups, the vagotomized (VAG) hamsters showed a significant increase in NF&#947;B activation in neutrophils and macrophages, and higher levels of interleukin (IL)-1ß, IL-6, interferon-&#947;, and tumor necrosis factor-a. VAG hamsters showed an increase in the expression of IL-8 and phosphorylated STAT3 during the first 24 h postinfection as well as slightly increased levels of transforming growth factor-ß on days 2-7 postinfection. No significant differences were demonstrated in the levels of IL-10. <b><i>Conclusions:</i></b> These results suggest that the vagus nerve plays an important role in the regulation of inflammation during ALA formation." @default.
• W2037454611 created "2016-06-24" @default.
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• W2037454611 date "2014-05-06" @default.
• W2037454611 modified "2023-10-18" @default.
• W2037454611 title "Vagotomy Induces Deregulation of the Inflammatory Response during the Development of Amoebic Liver Abscess in Hamsters" @default.
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• W2037454611 doi "https://doi.org/10.1159/000362240" @default.
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