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- W2037454892 abstract "Objective:To study the effect of yuntongding capsules on migraine model induced by reserpine. Methods: The model group mice daily subcutaneous injection of reserpine injection (250mg/kg), once a day, 10 days, fourth days respectively to the perfusion of high, medium and low dosage of yuntongding capsules suspension, yunfujing tablets suspension, the headache of suspension, model group are the same volume of 0.5%CMC, the blank control group intraperitoneal injection of the same volume of physiological saline, with the same volume of 0.5%CMC is on the fourth day, for 7 days, eleventh days of perfusion 30min, according to the standards of grading for each mice is evaluated, and then the eyeball blood coagulation time are measured, take brain tissue are measured serotonin (5-HT). Results: Compared with the blank group, Symptoms integral model group increased significantly (P<0.01), coagulation time is significantly shorter (P<0.05), the content of 5-HT in brain homogenate is significantly decreased (P<0.01), indicating the model is successfully; compared with the model group, Yunfujing tablets group can significantly reduce the symptom score (P<0.01), high, middle does halo pain capsule group and six headache tablets group can significantly reduce the symptom score (P<0.05), high, medium does yuntongding capsules group and six headache tablets group can make the migraine model mice clotting time significantly prolonged (P<0.05), small does of yuntongding capsules group can also make the migraine model mice clotting time significantly prolonged (P<0.01); high, medium does yuntongding capsules group and six headache tablets group can make the mice model of migraine brain homogenate 5-HT content increase obviously (P<0.05). Conclusion: Yuntongding capsules have a better therapeutic effect on migraine model induced by reserpine." @default.
- W2037454892 created "2016-06-24" @default.
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- W2037454892 date "2014-05-01" @default.
- W2037454892 modified "2023-09-27" @default.
- W2037454892 title "Effects of Yuntongding Capsules on Mice Model of Migraine Induced by Reserpine" @default.
- W2037454892 doi "https://doi.org/10.4028/www.scientific.net/amr.926-930.989" @default.
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