Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037457060> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2037457060 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILCell proliferation and invasion are critical for malignant progression, yet how these processes relate to each other and whether they regulate one another during metastasis is unknown. We show that invasiveness of breast cancer cells is associated with growth arrest due to p21CIP1 upregulation. Knockdown of p21CIP1 increases proliferation and suppresses invasion. Since p21CIP1 acts to inhibit Cyclin E during cell cycle progression, we demonstrated that a constitutively active form of Cyclin E had similar effects to p21CIP1 inhibition resulting in increased proliferation and suppressed invasion. We tested these findings in vivo in the Polyoma middle T mammary tumor model in which p21CIP1 was deleted. p21CIP1 knockout mice exhibited dramatic suppression of metastasis, independent of tumor growth. Metastasis suppression was associated with striking cytoskeletal reorganization leading to a shift from stress fibers to cortical actin, tightening of cell junctions, and cytokeratin upregulation. Thus, P21CIP1 regulates metastasis by mediating dynamic switching between invasion and proliferation.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2055. doi:1538-7445.AM2012-2055" @default.
- W2037457060 created "2016-06-24" @default.
- W2037457060 creator A5006124179 @default.
- W2037457060 date "2012-04-15" @default.
- W2037457060 modified "2023-09-25" @default.
- W2037457060 title "Abstract 2055: p21CIP1 mediates reciprocal switching between invasion and proliferation during metastasis" @default.
- W2037457060 doi "https://doi.org/10.1158/1538-7445.am2012-2055" @default.
- W2037457060 hasPublicationYear "2012" @default.
- W2037457060 type Work @default.
- W2037457060 sameAs 2037457060 @default.
- W2037457060 citedByCount "0" @default.
- W2037457060 crossrefType "proceedings-article" @default.
- W2037457060 hasAuthorship W2037457060A5006124179 @default.
- W2037457060 hasConcept C104317684 @default.
- W2037457060 hasConcept C121608353 @default.
- W2037457060 hasConcept C126322002 @default.
- W2037457060 hasConcept C127561419 @default.
- W2037457060 hasConcept C173396325 @default.
- W2037457060 hasConcept C199835354 @default.
- W2037457060 hasConcept C2776187077 @default.
- W2037457060 hasConcept C2779013556 @default.
- W2037457060 hasConcept C2779256057 @default.
- W2037457060 hasConcept C2780360765 @default.
- W2037457060 hasConcept C29537977 @default.
- W2037457060 hasConcept C502942594 @default.
- W2037457060 hasConcept C530470458 @default.
- W2037457060 hasConcept C54355233 @default.
- W2037457060 hasConcept C55493867 @default.
- W2037457060 hasConcept C62112901 @default.
- W2037457060 hasConcept C71924100 @default.
- W2037457060 hasConcept C81885089 @default.
- W2037457060 hasConcept C86803240 @default.
- W2037457060 hasConcept C94561458 @default.
- W2037457060 hasConceptScore W2037457060C104317684 @default.
- W2037457060 hasConceptScore W2037457060C121608353 @default.
- W2037457060 hasConceptScore W2037457060C126322002 @default.
- W2037457060 hasConceptScore W2037457060C127561419 @default.
- W2037457060 hasConceptScore W2037457060C173396325 @default.
- W2037457060 hasConceptScore W2037457060C199835354 @default.
- W2037457060 hasConceptScore W2037457060C2776187077 @default.
- W2037457060 hasConceptScore W2037457060C2779013556 @default.
- W2037457060 hasConceptScore W2037457060C2779256057 @default.
- W2037457060 hasConceptScore W2037457060C2780360765 @default.
- W2037457060 hasConceptScore W2037457060C29537977 @default.
- W2037457060 hasConceptScore W2037457060C502942594 @default.
- W2037457060 hasConceptScore W2037457060C530470458 @default.
- W2037457060 hasConceptScore W2037457060C54355233 @default.
- W2037457060 hasConceptScore W2037457060C55493867 @default.
- W2037457060 hasConceptScore W2037457060C62112901 @default.
- W2037457060 hasConceptScore W2037457060C71924100 @default.
- W2037457060 hasConceptScore W2037457060C81885089 @default.
- W2037457060 hasConceptScore W2037457060C86803240 @default.
- W2037457060 hasConceptScore W2037457060C94561458 @default.
- W2037457060 hasLocation W20374570601 @default.
- W2037457060 hasOpenAccess W2037457060 @default.
- W2037457060 hasPrimaryLocation W20374570601 @default.
- W2037457060 hasRelatedWork W1989669121 @default.
- W2037457060 hasRelatedWork W1990173574 @default.
- W2037457060 hasRelatedWork W1992828211 @default.
- W2037457060 hasRelatedWork W2001394696 @default.
- W2037457060 hasRelatedWork W2020697519 @default.
- W2037457060 hasRelatedWork W2044059620 @default.
- W2037457060 hasRelatedWork W2046256850 @default.
- W2037457060 hasRelatedWork W2051825462 @default.
- W2037457060 hasRelatedWork W2077926747 @default.
- W2037457060 hasRelatedWork W2124421170 @default.
- W2037457060 hasRelatedWork W2171849434 @default.
- W2037457060 hasRelatedWork W2316257662 @default.
- W2037457060 hasRelatedWork W2329090141 @default.
- W2037457060 hasRelatedWork W2334088621 @default.
- W2037457060 hasRelatedWork W2505658592 @default.
- W2037457060 hasRelatedWork W2506358754 @default.
- W2037457060 hasRelatedWork W2529304765 @default.
- W2037457060 hasRelatedWork W2564989714 @default.
- W2037457060 hasRelatedWork W2565936260 @default.
- W2037457060 hasRelatedWork W2953662460 @default.
- W2037457060 isParatext "false" @default.
- W2037457060 isRetracted "false" @default.
- W2037457060 magId "2037457060" @default.
- W2037457060 workType "article" @default.