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- W2037463404 abstract "1 The effects of mefenamic acid and Bay K 8644 on voltage-dependent nifedipine-sensitive inward Ba2+ currents in pig urethral myocytes were investigated by use of conventional whole-cell configuration patch clamp. 2 Mefenamic acid increased the peak amplitude of voltage-dependent nifedipine-sensitive inward Ba2+ current without shifting the position of the current–voltage relationship. 3 Mefenamic acid (300 μM) caused little shift in the activation curve although the voltage dependence of the steady-state inactivation was shifted to more positive potentials by 11 mV in the presence of mefenamic acid. 4 Bay K 8644 (100 nM) enhanced voltage-dependent nifedipine-sensitive inward Ba2+ currents in a concentration- and voltage-dependent manner, shifting the maximum of the current–voltage relationship by 10 mV in the hyperpolarizing direction. 5 Bay K 8644 (1 μM) significantly shifted the voltage dependence of the activation curve to more negative potentials by approximately 9 mV although Bay K 8644 caused little shift in the steady-state inactivation curve. 6 These results indicate that mefenamic acid increased voltage-dependent nifedipine-sensitive inward Ba2+ currents through the activation of L-type Ca2+ channels with different kinetics from those of Bay K 8644 in pig urethral myocytes. British Journal of Pharmacology (2005) 144, 919–925. doi:10.1038/sj.bjp.0706051" @default.
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- W2037463404 date "2005-04-01" @default.
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- W2037463404 title "Mefenamic acid as a novel activator of L-type voltage-dependent Ca<sup>2+</sup> channels in smooth muscle cells from pig proximal urethra" @default.
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- W2037463404 doi "https://doi.org/10.1038/sj.bjp.0706051" @default.
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