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- W2037463507 abstract "Several bisphosphonates including zoledronic acid (ZOL) are approved for treating bone metastases from breast cancer (BC). Recent trials demonstrated that ZOL prevents bone loss and reduces disease recurrence in early BC. This review uses pharmacodynamic, efficacy, and safety data from phase III trials of ZOL in early through metastatic BC to evaluate the dosing regimens used in each setting. The dosing frequencies of ZOL in early stage versus metastatic BC (4 mg 2--4 times per year versus monthly) are based on the respective levels of bone resorption and tumor burden. Data from ongoing clinical trials suggest that monthly dosing facilitates potential synergy between ZOL and chemotherapy in intermediate-risk BC and during neoadjuvant therapy. Overall, available data indicate that treatment with ZOL at appropriate intervals determined by disease characteristics helps attain key therapeutic goals in BC--maintaining skeletal integrity, reducing disease recurrence, and improving clinical outcomes." @default.
- W2037463507 created "2016-06-24" @default.
- W2037463507 creator A5025718393 @default.
- W2037463507 creator A5033285318 @default.
- W2037463507 creator A5047198395 @default.
- W2037463507 creator A5051980635 @default.
- W2037463507 creator A5070338465 @default.
- W2037463507 date "2011-08-01" @default.
- W2037463507 modified "2023-09-26" @default.
- W2037463507 title "Dosing of zoledronic acid throughout the treatment continuum in breast cancer" @default.
- W2037463507 cites W1532226663 @default.
- W2037463507 cites W1661249198 @default.
- W2037463507 cites W1672597576 @default.
- W2037463507 cites W1761951195 @default.
- W2037463507 cites W1884945428 @default.
- W2037463507 cites W1906721103 @default.
- W2037463507 cites W1913264660 @default.
- W2037463507 cites W1928668153 @default.
- W2037463507 cites W1941723515 @default.
- W2037463507 cites W1948838904 @default.
- W2037463507 cites W1951349736 @default.
- W2037463507 cites W1961026612 @default.
- W2037463507 cites W1964124222 @default.
- W2037463507 cites W1964914901 @default.
- W2037463507 cites W1968048788 @default.
- W2037463507 cites W1969612650 @default.
- W2037463507 cites W1975236199 @default.
- W2037463507 cites W1976558228 @default.
- W2037463507 cites W1976680910 @default.
- W2037463507 cites W1988710169 @default.
- W2037463507 cites W1989014251 @default.
- W2037463507 cites W1990877651 @default.
- W2037463507 cites W1991668450 @default.
- W2037463507 cites W1991705854 @default.
- W2037463507 cites W1993035292 @default.
- W2037463507 cites W1993322108 @default.
- W2037463507 cites W1993479864 @default.
- W2037463507 cites W1995615104 @default.
- W2037463507 cites W1996712833 @default.
- W2037463507 cites W2000293927 @default.
- W2037463507 cites W2000519574 @default.
- W2037463507 cites W2002094338 @default.
- W2037463507 cites W2006131871 @default.
- W2037463507 cites W2011926580 @default.
- W2037463507 cites W2025363160 @default.
- W2037463507 cites W2028243830 @default.
- W2037463507 cites W2028721164 @default.
- W2037463507 cites W2037542472 @default.
- W2037463507 cites W2039608151 @default.
- W2037463507 cites W2040177859 @default.
- W2037463507 cites W2041868422 @default.
- W2037463507 cites W2068530253 @default.
- W2037463507 cites W2072508802 @default.
- W2037463507 cites W2073380111 @default.
- W2037463507 cites W2075833658 @default.
- W2037463507 cites W2076370157 @default.
- W2037463507 cites W2077073060 @default.
- W2037463507 cites W2081378515 @default.
- W2037463507 cites W2088014747 @default.
- W2037463507 cites W2096360340 @default.
- W2037463507 cites W2099178340 @default.
- W2037463507 cites W2100291515 @default.
- W2037463507 cites W2107118598 @default.
- W2037463507 cites W2112780046 @default.
- W2037463507 cites W2114358979 @default.
- W2037463507 cites W2114581944 @default.
- W2037463507 cites W2115871403 @default.
- W2037463507 cites W2115962082 @default.
- W2037463507 cites W2117696515 @default.
- W2037463507 cites W2122429800 @default.
- W2037463507 cites W2122972229 @default.
- W2037463507 cites W2123367264 @default.
- W2037463507 cites W2130934441 @default.
- W2037463507 cites W2134071321 @default.
- W2037463507 cites W2135535385 @default.
- W2037463507 cites W2135643059 @default.
- W2037463507 cites W2135743613 @default.
- W2037463507 cites W2137200429 @default.
- W2037463507 cites W2137411979 @default.
- W2037463507 cites W2139959697 @default.
- W2037463507 cites W2140516514 @default.
- W2037463507 cites W2142234592 @default.
- W2037463507 cites W2143151890 @default.
- W2037463507 cites W2143254775 @default.
- W2037463507 cites W2143939516 @default.
- W2037463507 cites W2145587658 @default.
- W2037463507 cites W2146194560 @default.
- W2037463507 cites W2146810449 @default.
- W2037463507 cites W2146941412 @default.
- W2037463507 cites W2148096512 @default.
- W2037463507 cites W2148226416 @default.
- W2037463507 cites W2148639087 @default.
- W2037463507 cites W2151283051 @default.
- W2037463507 cites W2151447010 @default.
- W2037463507 cites W2152409486 @default.
- W2037463507 cites W2152412969 @default.
- W2037463507 cites W2154614446 @default.
- W2037463507 cites W2155018925 @default.
- W2037463507 cites W2155462687 @default.
- W2037463507 cites W2155803397 @default.