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- W2037463622 endingPage "465" @default.
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- W2037463622 abstract "Viral infection has been associated with a starvation-like state in Drosophila melanogaster. Because starvation and inhibiting TOR kinase activity in vivo result in blocked oocyte production, we hypothesized that viral infection would also result in compromised oogenesis. Wild-type flies were injected with flock house virus (FHV) and survival and embryo production were monitored. Infected flies had a dose-responsive loss of fecundity that corresponded to a global reduction in Akt/TOR signaling. Highly penetrant egg chamber destruction mid-way through oogenesis was noted and FHV coat protein was detected within developing egg chambers. As seen with in vivo TOR inhibition, oogenesis was partially rescued in loss of function discs large and merlin mutants. As expected, mutants in genes known to be involved in virus internalization and trafficking [Clathrin heavy chain (chc) and synaptotagmin] survive longer during infection. However, oogenesis was rescued only in chc mutants. This suggests that viral response mechanisms that control fly survival and egg chamber survival are separable. The genetic and signaling requirements for oocyte destruction delineated here represent a novel host–virus interaction with implications for the control of both fly and virus populations. genesis 50:453–465, 2012. © 2012 Wiley Periodicals, Inc." @default.
- W2037463622 created "2016-06-24" @default.
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- W2037463622 date "2012-01-25" @default.
- W2037463622 modified "2023-09-27" @default.
- W2037463622 title "Oocyte destruction is activated during viral infection" @default.
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- W2037463622 doi "https://doi.org/10.1002/dvg.22004" @default.
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