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- W2037470242 abstract "Abstract Objective: Involvement of loci on chromosome 17, including retinoic acid receptor alpha (RARA) in nonsyndromic oral clefts has been reported in Caucasian populations, although never investigated in Asian populations. The purpose of the present study was to investigate several loci on chromosome 17, including RARA, in Chinese families. Participants: Thirty-six multiplex families (310 individuals), ascertained through nonsyndromic cleft lip with or without cleft palate surgical probands from hospitals in Shanghai, China, participated in the present study. There were 23 families whose probands had cleft lip and cleft palate (CLP) and 13 with cleft lip alone (CL). Results: Seventeen markers, spanning chromosome 17 and about 10 cM apart were assessed. Logarithm of odds ratio (LOD) scores (two point and multipoint), model-free linkage analyses, and allelic association tests (transmission/disequilibrium, Fisher's exact tests, and chi-square) were performed on the total family sample, families with CLP p..." @default.
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- W2037470242 date "2003-01-01" @default.
- W2037470242 modified "2023-10-01" @default.
- W2037470242 title "Chromosome 17: Gene Mapping Studies of Cleft Lip With or Without Cleft Palate in Chinese Families" @default.
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- W2037470242 doi "https://doi.org/10.1597/1545-1569(2003)040<0071:cgmsoc>2.0.co;2" @default.
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