FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037475795> ?p ?o ?g. }

• W2037475795 endingPage "48" @default.
• W2037475795 startingPage "40" @default.
• W2037475795 abstract "Components of metabolic syndrome (MS) have been individually linked to colorectal cancer risk and prognosis; however, an understanding of the dominant mechanisms is lacking.Twenty-one patients (10 MS; 11 non-MS) with resectable colorectal cancer were prospectively enrolled. Patients were classified for MS by the World Health Organization criteria and tested for circulating vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), insulin-like growth factor-1 (IGF-1), fasting insulin, and tumor expression of IGF-1 receptor (IGF-1R), insulin-receptor (IR) and receptor for advanced glycation end-products (RAGE). Circulating markers were re-tested 6 months after surgery.The MS group had significantly higher baseline and post-operative fasting insulin levels (p < 0.001 and 0.003). No differences were observed in circulating IL-6, VEGF, IGF-1 and free IGF-1. By immunohistochemistry (IHC), IGF-1R expression was significantly higher in tumor vs. normal tissues (p < 0.001) while IR expression showed no difference. Interestingly, 64% of tumors demonstrated high IR positivity in the vessels within or surrounding the tumor stroma, but not in the vessels away from the tumor. By reverse transcription polymerase chain reaction (RT-PCR), tumor IGF-1R over-expression (80%) was confirmed, but there was no difference between MS and non-MS patients. Tumor RAGE over-expression was found in 67% of patients and was equally distributed between the two groups.Hyperinsulinemia was the only significant factor distinguishing patients with colorectal cancer who have MS. The preferential over-expression of IR in the peri-tumoral microvessels suggests that hyperinsulinemia might contribute to colorectal cancer growth by enhancing angiogenesis." @default.
• W2037475795 created "2016-06-24" @default.
• W2037475795 creator A5002289370 @default.
• W2037475795 creator A5008971307 @default.
• W2037475795 creator A5014513676 @default.
• W2037475795 creator A5025906534 @default.
• W2037475795 creator A5057700912 @default.
• W2037475795 creator A5064716632 @default.
• W2037475795 creator A5066579890 @default.
• W2037475795 creator A5072672228 @default.
• W2037475795 creator A5076324164 @default.
• W2037475795 date "2014-01-01" @default.
• W2037475795 modified "2023-10-05" @default.
• W2037475795 title "Metabolic syndrome and colorectal cancer: Is hyperinsulinemia/insulin receptor-mediated angiogenesis a critical process?" @default.
• W2037475795 cites W1915017670 @default.
• W2037475795 cites W1971540233 @default.
• W2037475795 cites W1985301861 @default.
• W2037475795 cites W1988584992 @default.
• W2037475795 cites W1988778035 @default.
• W2037475795 cites W1997239568 @default.
• W2037475795 cites W2008981948 @default.
• W2037475795 cites W2009292210 @default.
• W2037475795 cites W2012396851 @default.
• W2037475795 cites W2013932846 @default.
• W2037475795 cites W2022736437 @default.
• W2037475795 cites W2037077736 @default.
• W2037475795 cites W2058699849 @default.
• W2037475795 cites W2066218635 @default.
• W2037475795 cites W2066898102 @default.
• W2037475795 cites W2077388314 @default.
• W2037475795 cites W2078807483 @default.
• W2037475795 cites W2084249911 @default.
• W2037475795 cites W2106321700 @default.
• W2037475795 cites W2120888184 @default.
• W2037475795 cites W2134021551 @default.
• W2037475795 cites W2134293572 @default.
• W2037475795 cites W2142265270 @default.
• W2037475795 cites W2142808344 @default.
• W2037475795 cites W2147375465 @default.
• W2037475795 cites W2150081825 @default.
• W2037475795 cites W2154968370 @default.
• W2037475795 cites W2157769714 @default.
• W2037475795 cites W2163072132 @default.
• W2037475795 cites W2165269767 @default.
• W2037475795 cites W2229509524 @default.
• W2037475795 cites W4250413101 @default.
• W2037475795 cites W4366064733 @default.
• W2037475795 doi "https://doi.org/10.1016/j.jgo.2013.11.004" @default.
• W2037475795 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4527303" @default.
• W2037475795 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24484717" @default.
• W2037475795 hasPublicationYear "2014" @default.
• W2037475795 type Work @default.
• W2037475795 sameAs 2037475795 @default.
• W2037475795 citedByCount "22" @default.
• W2037475795 countsByYear W20374757952013 @default.
• W2037475795 countsByYear W20374757952014 @default.
• W2037475795 countsByYear W20374757952015 @default.
• W2037475795 countsByYear W20374757952016 @default.
• W2037475795 countsByYear W20374757952017 @default.
• W2037475795 countsByYear W20374757952018 @default.
• W2037475795 countsByYear W20374757952019 @default.
• W2037475795 countsByYear W20374757952020 @default.
• W2037475795 countsByYear W20374757952021 @default.
• W2037475795 countsByYear W20374757952022 @default.
• W2037475795 crossrefType "journal-article" @default.
• W2037475795 hasAuthorship W2037475795A5002289370 @default.
• W2037475795 hasAuthorship W2037475795A5008971307 @default.
• W2037475795 hasAuthorship W2037475795A5014513676 @default.
• W2037475795 hasAuthorship W2037475795A5025906534 @default.
• W2037475795 hasAuthorship W2037475795A5057700912 @default.
• W2037475795 hasAuthorship W2037475795A5064716632 @default.
• W2037475795 hasAuthorship W2037475795A5066579890 @default.
• W2037475795 hasAuthorship W2037475795A5072672228 @default.
• W2037475795 hasAuthorship W2037475795A5076324164 @default.
• W2037475795 hasBestOaLocation W20374757951 @default.
• W2037475795 hasConcept C112446052 @default.
• W2037475795 hasConcept C121608353 @default.
• W2037475795 hasConcept C126322002 @default.
• W2037475795 hasConcept C134018914 @default.
• W2037475795 hasConcept C167734588 @default.
• W2037475795 hasConcept C170493617 @default.
• W2037475795 hasConcept C204232928 @default.
• W2037475795 hasConcept C2775960820 @default.
• W2037475795 hasConcept C2777025900 @default.
• W2037475795 hasConcept C2777391703 @default.
• W2037475795 hasConcept C2779306644 @default.
• W2037475795 hasConcept C2780394083 @default.
• W2037475795 hasConcept C2780689927 @default.
• W2037475795 hasConcept C2780988686 @default.
• W2037475795 hasConcept C526805850 @default.
• W2037475795 hasConcept C71924100 @default.
• W2037475795 hasConceptScore W2037475795C112446052 @default.
• W2037475795 hasConceptScore W2037475795C121608353 @default.
• W2037475795 hasConceptScore W2037475795C126322002 @default.
• W2037475795 hasConceptScore W2037475795C134018914 @default.
• W2037475795 hasConceptScore W2037475795C167734588 @default.
• W2037475795 hasConceptScore W2037475795C170493617 @default.
• W2037475795 hasConceptScore W2037475795C204232928 @default.

• next