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• W2037478045 endingPage "H762" @default.
• W2037478045 startingPage "H752" @default.
• W2037478045 abstract "In patients with spinal cord injury (SCI), somatosympathetic reflexes produce exaggerated decreases in skin blood flow below the lesion. This hypoperfusion appears to result from an increased responsiveness of cutaneous arterial vessels to neural activation. Here we investigated the mechanisms that underlie SCI-induced enhancement of neurovascular transmission in a cutaneous vessel, the rat tail artery. Isometric contractions of arterial segments from T11 spinal cord transected and sham-operated rats were compared 6 wk postoperatively. SCI more than doubled the amplitudes of contractions of arteries in response to moderate frequencies of nerve stimulation (0.1 to 1 Hz). In arteries from SCI rats, but not those from sham-operated rats, the L-type Ca 2+ channel blocker nifedipine (1 μM) reduced the amplitudes of nerve-evoked contractions. Furthermore, while the sensitivity to the agonists phenylephrine (α 1 -adrenoceptor selective) and clonidine (α 2 -adrenoceptor selective) did not differ significantly between arteries from SCI and sham-operated rats, nifedipine had a greater inhibitory effect on contractions to both agents in arteries from SCI rats. Although sensitivity to clonidine was unchanged, SCI selectively reduced the contribution of postjunctional α 2 -adenceptors to nerve-evoked contractions. In arteries from unoperated rats, the L-type channel agonist BAY K 8644 (0.1 μM) produced a similar enhancement of nerve-evoked contraction to that produced by SCI and also selectively reduced the contribution of α 2 -adrenceptors to these responses. Together the findings demonstrate that the SCI-induced enhancement of neurovascular transmission in the rat tail artery can largely be accounted for by an increased contribution of L-type Ca 2+ channels to activation of the vascular smooth muscle." @default.
• W2037478045 created "2016-06-24" @default.
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• W2037478045 date "2012-02-01" @default.
• W2037478045 modified "2023-10-15" @default.
• W2037478045 title "Prominent contribution of L-type Ca²⁺channels to cutaneous neurovascular transmission that is revealed after spinal cord injury augments vasoconstriction" @default.
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• W2037478045 doi "https://doi.org/10.1152/ajpheart.00745.2011" @default.
• W2037478045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22081708" @default.
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