Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037480503> ?p ?o ?g. }
- W2037480503 endingPage "90" @default.
- W2037480503 startingPage "79" @default.
- W2037480503 abstract "A novel process for generating sustained release (SR) particles for pulmonary drug delivery is described. High purity nanoparticles of a hydrophilic, ionised drug are entrapped within hydrophobic microspheres using a spray-drying approach. Sustained release of the model drug, terbutaline sulphate (TS), from the microspheres was found to be proportional to drug loading and phospholipid content. Microspheres with a 33% drug loading exhibited sustained release of 32.7% over 180 min in phosphate buffer. Release was not significantly different in simulated lung fluids. No significant burst release was observed which suggested that nanoparticles were coated effectively during spray-drying. The absence of nanoparticles at the microsphere surface was confirmed with confocal microscopy. The sustained release microspheres were formulated as a carrier-free dry powder for inhalation, and exhibited a favourable Fine Particle Fraction (FPF) of 46.5+/-1.8% and Mass Median Aerodynamic Diameter (MMAD) of 3.93+/-0.12 microm." @default.
- W2037480503 created "2016-06-24" @default.
- W2037480503 creator A5025140717 @default.
- W2037480503 creator A5046844483 @default.
- W2037480503 creator A5089434311 @default.
- W2037480503 date "2005-05-01" @default.
- W2037480503 modified "2023-10-16" @default.
- W2037480503 title "Novel sustained release microspheres for pulmonary drug delivery" @default.
- W2037480503 cites W118779128 @default.
- W2037480503 cites W1607515676 @default.
- W2037480503 cites W1810380748 @default.
- W2037480503 cites W1858228878 @default.
- W2037480503 cites W188879743 @default.
- W2037480503 cites W1971133657 @default.
- W2037480503 cites W1980803266 @default.
- W2037480503 cites W1983692314 @default.
- W2037480503 cites W1991279996 @default.
- W2037480503 cites W2013258807 @default.
- W2037480503 cites W2013550147 @default.
- W2037480503 cites W2017138863 @default.
- W2037480503 cites W2022069744 @default.
- W2037480503 cites W2024458711 @default.
- W2037480503 cites W2025105060 @default.
- W2037480503 cites W2029673185 @default.
- W2037480503 cites W2036498002 @default.
- W2037480503 cites W2043111593 @default.
- W2037480503 cites W2045325511 @default.
- W2037480503 cites W2045426301 @default.
- W2037480503 cites W2047503737 @default.
- W2037480503 cites W2049228357 @default.
- W2037480503 cites W2051931515 @default.
- W2037480503 cites W2059766794 @default.
- W2037480503 cites W2069715353 @default.
- W2037480503 cites W2080200241 @default.
- W2037480503 cites W2082865634 @default.
- W2037480503 cites W2086130473 @default.
- W2037480503 cites W2097120859 @default.
- W2037480503 cites W2107883084 @default.
- W2037480503 cites W2143835782 @default.
- W2037480503 cites W2146362494 @default.
- W2037480503 cites W2164994085 @default.
- W2037480503 cites W2166837612 @default.
- W2037480503 cites W2166857188 @default.
- W2037480503 doi "https://doi.org/10.1016/j.jconrel.2005.01.003" @default.
- W2037480503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15866336" @default.
- W2037480503 hasPublicationYear "2005" @default.
- W2037480503 type Work @default.
- W2037480503 sameAs 2037480503 @default.
- W2037480503 citedByCount "150" @default.
- W2037480503 countsByYear W20374805032012 @default.
- W2037480503 countsByYear W20374805032013 @default.
- W2037480503 countsByYear W20374805032014 @default.
- W2037480503 countsByYear W20374805032015 @default.
- W2037480503 countsByYear W20374805032016 @default.
- W2037480503 countsByYear W20374805032017 @default.
- W2037480503 countsByYear W20374805032018 @default.
- W2037480503 countsByYear W20374805032019 @default.
- W2037480503 countsByYear W20374805032020 @default.
- W2037480503 countsByYear W20374805032021 @default.
- W2037480503 countsByYear W20374805032022 @default.
- W2037480503 countsByYear W20374805032023 @default.
- W2037480503 crossrefType "journal-article" @default.
- W2037480503 hasAuthorship W2037480503A5025140717 @default.
- W2037480503 hasAuthorship W2037480503A5046844483 @default.
- W2037480503 hasAuthorship W2037480503A5089434311 @default.
- W2037480503 hasConcept C126322002 @default.
- W2037480503 hasConcept C127413603 @default.
- W2037480503 hasConcept C13245373 @default.
- W2037480503 hasConcept C147789679 @default.
- W2037480503 hasConcept C155672457 @default.
- W2037480503 hasConcept C163588942 @default.
- W2037480503 hasConcept C171250308 @default.
- W2037480503 hasConcept C178790620 @default.
- W2037480503 hasConcept C185592680 @default.
- W2037480503 hasConcept C187530423 @default.
- W2037480503 hasConcept C189942447 @default.
- W2037480503 hasConcept C192562407 @default.
- W2037480503 hasConcept C2776042228 @default.
- W2037480503 hasConcept C2776954882 @default.
- W2037480503 hasConcept C2777419714 @default.
- W2037480503 hasConcept C2777521759 @default.
- W2037480503 hasConcept C2779587474 @default.
- W2037480503 hasConcept C2779820397 @default.
- W2037480503 hasConcept C2780035454 @default.
- W2037480503 hasConcept C2780261241 @default.
- W2037480503 hasConcept C42219234 @default.
- W2037480503 hasConcept C42360764 @default.
- W2037480503 hasConcept C43617362 @default.
- W2037480503 hasConcept C71924100 @default.
- W2037480503 hasConcept C77281830 @default.
- W2037480503 hasConcept C82085835 @default.
- W2037480503 hasConcept C98274493 @default.
- W2037480503 hasConceptScore W2037480503C126322002 @default.
- W2037480503 hasConceptScore W2037480503C127413603 @default.
- W2037480503 hasConceptScore W2037480503C13245373 @default.
- W2037480503 hasConceptScore W2037480503C147789679 @default.
- W2037480503 hasConceptScore W2037480503C155672457 @default.
- W2037480503 hasConceptScore W2037480503C163588942 @default.