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- W2037486590 endingPage "105103" @default.
- W2037486590 startingPage "105103" @default.
- W2037486590 abstract "Due to their unique structure, poly(amidoamine) (PAMAM) dendrimers have been widely used in medical applications. However, PAMAM dendrimers bearing amino terminals show certain cytotoxicity. In order to improve their biocompatibility, we modified Generation-5 PAMAM dendrimers by conjugating them with poly(ethylene glycol) (PEG) of two different molecular weights and different number of chains. The IC(50) values of PEGylated dendrimers were 12-105 fold higher than those of PAMAM dendrimers. To investigate the influence of PEGylation on PAMAM-induced cytotoxicity, the intracellular responses, reactive oxygen species (ROS) content, mitochondrial membrane potential (MMP), and apoptosis were examined. The results indicated that conjugation with PEG could effectively reduce the PAMAM-induced cell apoptosis by attenuating the ROS production and inhibiting PAMAM-induced MMP collapse. Meanwhile, dendrimers conjugated with less PEG of lower molecular weight did not significantly change the endocytic properties. Dendrimers conjugated with more PEG of higher molecular weight were much less cytotoxic. This study provided a novel insight into the effects of PEGylation on the decrease of cytotoxicity at the molecular level." @default.
- W2037486590 created "2016-06-24" @default.
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- W2037486590 date "2009-02-16" @default.
- W2037486590 modified "2023-10-10" @default.
- W2037486590 title "The decrease of PAMAM dendrimer-induced cytotoxicity by PEGylation via attenuation of oxidative stress" @default.
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- W2037486590 doi "https://doi.org/10.1088/0957-4484/20/10/105103" @default.
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