Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037489782> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2037489782 endingPage "283" @default.
- W2037489782 startingPage "283" @default.
- W2037489782 abstract "Dendritic cells (DCs) are an important innate immune cell type which is the bridge between innate and adaptive immunity. Mounting experimental evidence suggests that manipulating DCs represents a powerful means to enhance host defence against intracellular infectious diseases. We have developed several strategies to manipulate DCs either in vivo or in vitro for the purpose of enhancing the effect of vaccination or immunotherapeutics. In vivo delivery of transgene encoding GM-CSF (granulocyte/macrophage colony-stimulating factor), a DC-activating cytokine, increases the number and activation status of DCs at various tissue sites and enhances antimicrobial immune responses in murine models. Co-expression or co-delivery of GM-CSF gene transfer vector with an antimicrobial vaccine enhances microbial antigen-specific T-cell responses and immune protection. Murine bone marrow-derived DCs are being manipulated in vitro and exploited as a vaccine delivery system. Transduction of DCs with a virus-vectored tuberculosis vaccine is a powerful way to activate T-cells in vivo. Such genetically modified DC vaccines can be administered either parenterally or mucosally via the respiratory tract." @default.
- W2037489782 created "2016-06-24" @default.
- W2037489782 creator A5040872695 @default.
- W2037489782 creator A5067083694 @default.
- W2037489782 creator A5072686480 @default.
- W2037489782 creator A5084354611 @default.
- W2037489782 date "2006-04-01" @default.
- W2037489782 modified "2023-09-27" @default.
- W2037489782 title "Manipulation of dendritic cells for host defence against intracellular infections" @default.
- W2037489782 cites W1661544713 @default.
- W2037489782 cites W1985321490 @default.
- W2037489782 cites W2003253889 @default.
- W2037489782 cites W2005920741 @default.
- W2037489782 cites W2053655431 @default.
- W2037489782 cites W2065661920 @default.
- W2037489782 cites W2067200709 @default.
- W2037489782 cites W2067931073 @default.
- W2037489782 cites W2104190613 @default.
- W2037489782 cites W2123623434 @default.
- W2037489782 cites W2128519954 @default.
- W2037489782 cites W2139605495 @default.
- W2037489782 cites W2144353758 @default.
- W2037489782 cites W2146396140 @default.
- W2037489782 cites W2156637796 @default.
- W2037489782 cites W2160591940 @default.
- W2037489782 cites W2161503027 @default.
- W2037489782 cites W2415807326 @default.
- W2037489782 cites W2887620167 @default.
- W2037489782 doi "https://doi.org/10.1042/bst20060283" @default.
- W2037489782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16545095" @default.
- W2037489782 hasPublicationYear "2006" @default.
- W2037489782 type Work @default.
- W2037489782 sameAs 2037489782 @default.
- W2037489782 citedByCount "8" @default.
- W2037489782 countsByYear W20374897822013 @default.
- W2037489782 countsByYear W20374897822014 @default.
- W2037489782 countsByYear W20374897822016 @default.
- W2037489782 crossrefType "journal-article" @default.
- W2037489782 hasAuthorship W2037489782A5040872695 @default.
- W2037489782 hasAuthorship W2037489782A5067083694 @default.
- W2037489782 hasAuthorship W2037489782A5072686480 @default.
- W2037489782 hasAuthorship W2037489782A5084354611 @default.
- W2037489782 hasConcept C102230213 @default.
- W2037489782 hasConcept C104317684 @default.
- W2037489782 hasConcept C136449434 @default.
- W2037489782 hasConcept C153726182 @default.
- W2037489782 hasConcept C193419808 @default.
- W2037489782 hasConcept C203014093 @default.
- W2037489782 hasConcept C2778170410 @default.
- W2037489782 hasConcept C55493867 @default.
- W2037489782 hasConcept C86803240 @default.
- W2037489782 hasConcept C8891405 @default.
- W2037489782 hasConcept C95444343 @default.
- W2037489782 hasConceptScore W2037489782C102230213 @default.
- W2037489782 hasConceptScore W2037489782C104317684 @default.
- W2037489782 hasConceptScore W2037489782C136449434 @default.
- W2037489782 hasConceptScore W2037489782C153726182 @default.
- W2037489782 hasConceptScore W2037489782C193419808 @default.
- W2037489782 hasConceptScore W2037489782C203014093 @default.
- W2037489782 hasConceptScore W2037489782C2778170410 @default.
- W2037489782 hasConceptScore W2037489782C55493867 @default.
- W2037489782 hasConceptScore W2037489782C86803240 @default.
- W2037489782 hasConceptScore W2037489782C8891405 @default.
- W2037489782 hasConceptScore W2037489782C95444343 @default.
- W2037489782 hasIssue "2" @default.
- W2037489782 hasLocation W20374897821 @default.
- W2037489782 hasLocation W20374897822 @default.
- W2037489782 hasOpenAccess W2037489782 @default.
- W2037489782 hasPrimaryLocation W20374897821 @default.
- W2037489782 hasRelatedWork W1175477002 @default.
- W2037489782 hasRelatedWork W2019596936 @default.
- W2037489782 hasRelatedWork W2082627135 @default.
- W2037489782 hasRelatedWork W2086739630 @default.
- W2037489782 hasRelatedWork W2141330728 @default.
- W2037489782 hasRelatedWork W2188294308 @default.
- W2037489782 hasRelatedWork W2364577086 @default.
- W2037489782 hasRelatedWork W2884963187 @default.
- W2037489782 hasRelatedWork W3037049398 @default.
- W2037489782 hasRelatedWork W3140535742 @default.
- W2037489782 hasVolume "34" @default.
- W2037489782 isParatext "false" @default.
- W2037489782 isRetracted "false" @default.
- W2037489782 magId "2037489782" @default.
- W2037489782 workType "article" @default.