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- W2037492035 endingPage "433" @default.
- W2037492035 startingPage "423" @default.
- W2037492035 abstract "The fibrinolytic system generates plasmin, which dissolves fibrin in haemostatic plugs and in thrombi. It is often regarded simply as a secondary phenomenon responsive to the generation of thrombi but it is, rather, in dynamic balance with fibrin formation, such that abnormalities in either can lead to thrombosis. This chapter summarizes the fibrinolytic system and its regulation. It considers the components of the system in blood, both in plasma and in circulating cells, with emphasis on protease–inhibitor balance. It goes on to discuss local fibrinolytic potential in thrombi, both venous and arterial, and in the diseased vessel wall, presenting evidence that increased local inhibition of fibrinolysis by PAI-1, PAI-2 and α2-antiplasmin is intimately involved in thrombus stability and in the generation of fibrin-rich vessel wall lesions. Finally, it reviews the evidence that defective plasma fibrinolysis has a causal role in venous and arterial thrombosis." @default.
- W2037492035 created "2016-06-24" @default.
- W2037492035 creator A5025642740 @default.
- W2037492035 date "1999-09-01" @default.
- W2037492035 modified "2023-10-14" @default.
- W2037492035 title "Fibrinolysis and thrombosis" @default.
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- W2037492035 doi "https://doi.org/10.1053/beha.1999.0034" @default.
- W2037492035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7841601" @default.
- W2037492035 hasPublicationYear "1999" @default.
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